Huntington's disease: Treatment with dipropylacetic acid and gamma-aminobutyric acid

Neurology ◽  
1976 ◽  
Vol 26 (1) ◽  
pp. 61-61 ◽  
Author(s):  
I. SHOULSON ◽  
R. KARTZINEL ◽  
T. N. CHASE
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Disease Treatment

Altered behavioral responses to gamma-aminobutyric acid pharmacological agents in a mouse model of Huntington's disease

2017 ◽  
Vol 32 (11) ◽  
pp. 1600-1609 ◽  
Author(s):  
Yi-Ting Hsu ◽  
Ya-Gin Chang ◽  
Ching-Pang Chang ◽  
Jian-Jing Siew ◽  
Hui-Mei Chen ◽  
...  
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Behavioral Responses ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Pharmacological Agents

Enhanced striatopallidal gamma‐aminobutyric acid (GABA) A receptor transmission in mouse models of huntington's disease

2019 ◽  
Vol 34 (5) ◽  
pp. 684-696 ◽  
Author(s):  
Tamara Perez‐Rosello ◽  
Simon Gelman ◽  
Geoffrey Tombaugh ◽  
Roger Cachope ◽  
Vahri Beaumont ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Mouse Models ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Gaba A

scholarly journals Targeting the neuronal calcium sensor DREAM with small-molecules for Huntington’s disease treatment

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Alejandro Lopez-Hurtado ◽  
Diego A. Peraza ◽  
Pilar Cercos ◽  
Laura Lagartera ◽  
Paz Gonzalez ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Small Molecules ◽  
Huntington’S Disease ◽  
Calcium Sensor ◽  
Disease Treatment ◽  
Neuronal Calcium Sensor

scholarly journals Diphenyl diselenide protects a Caenorhabditis elegans model for Huntington's disease by activation of the antioxidant pathway and a decrease in protein aggregation

Metallomics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1142-1158
Author(s):  
Fabiane Bicca Obetine Baptista ◽  
Leticia Priscilla Arantes ◽  
Marina Lopes Machado ◽  
Aline Franzen da Silva ◽  
Larissa Marafiga Cordeiro ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Protein Misfolding ◽  
Nuclear Translocation ◽  
Oxygen Species ◽  
Diphenyl Diselenide ◽  
Disease Treatment ◽  
C Elegans ◽  
Superoxide Dismutase 3 ◽  
Protein Misfolding And Aggregation

The effect of (PhSe)2 in a C. elegans model for Huntington's disease. Treatment with (PhSe)2 triggered the nuclear translocation and activation of DAF-16 transcription factor in C. elegans, inducing the expression of superoxide dismutase-3 (SOD-3) and heat shock protein-16.2 (HSP-16.2). SOD-3 acts on reactive oxygen species (ROS) detoxification, and HSP-16.2 decreases protein misfolding and aggregation, which occur in HD.

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