Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immune-response gene products (Ia antigens)

Neurology ◽  
1986 ◽  
Vol 36 (7) ◽  
pp. 964-964 ◽  
Author(s):  
M. Rodriguez ◽  
W. P. Lafuse ◽  
J. Leibowitz ◽  
C. S. David
Keyword(s):  
Immune Response ◽  
Monoclonal Antibodies ◽  
Immune Response Gene ◽  
Gene Products ◽  
Theiler's Virus ◽  
Response Gene ◽  
Ia Antigens ◽  
Partial Suppression

Therapy of autoimmune diseases with antibodies to immune response gene products

1984 ◽  
Vol 5 (3) ◽  
pp. 43-45
Author(s):  
Lawrence Steinman ◽  
Subramaniam Sriram ◽  
Matthew K. Waldor
Keyword(s):  
Immune Response ◽  
Autoimmune Diseases ◽  
Immune Response Gene ◽  
Gene Products ◽  
Response Gene

scholarly journals The xid gene controls Ia.W39-associated immune response gene function.

1981 ◽  
Vol 153 (5) ◽  
pp. 1113-1123 ◽  
Author(s):  
L J Rosenwasser ◽  
B T Huber
Keyword(s):  
Immune Response ◽  
Gene Function ◽  
Immune Response Gene ◽  
T Cell Proliferation ◽  
Response Gene ◽  
Histocompatibility Complex ◽  
Ia Antigens ◽  
Antigen Presenting ◽  
Ir Genes

Immune response (Ir) genes are encoded for by the I region of the major histocompatibility complex (MHC). A class of serologically defined specificities, Ia antigens, is also encoded for by genes within this region. A new Ia specificity, Ia.W39, has recently been defined. It is private for I-Ab and its expression is controlled by a gene on the X-chromosome. Using different approaches, the role of Ia.W39 in the immune response of H-2b mice to beef insulin was examined in a macrophage-dependent T cell proliferation assay. It was found that beef insulin-related Ir gene function was associated with the expression of Ia.W39 by antigen-presenting macrophages and that control of this Ir gene function was X-linked (xid gene).

scholarly journals GENETIC CONTROL OF IMMUNE RESPONSES IN VITRO

1973 ◽  
Vol 138 (5) ◽  
pp. 1107-1120 ◽  
Author(s):  
Judith A. Kapp ◽  
Carl W. Pierce ◽  
Baruj Benacerraf
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Plaque Assay ◽  
Immune Response Gene ◽  
Spleen Cells ◽  
Response Gene ◽  
In Vitro System ◽  
Cellular Events

In vivo, the antibody response in mice to the random terpolymer L-glutamic acid50-L-alanine30-L-tyrosine10 (GAT) is controlled by a histocompatibility-linked immune response gene(s). We have studied antibody responses by spleen cells from responder and nonresponder mice to GAT and GAT complexed to methylated bovine serum albumin (GAT-MBSA) in vitro. Cells producing antibodies specific for GAT were enumerated in a modified Jerne plaque assay using GAT coupled to sheep erythrocytes as indicator cells. Soluble GAT stimulated development of IgG GAT-specific plaque-forming cell (PFC) responses in cultures of spleen cells from responder mice, C57Bl/6 (H-2b), F1 (C57 x SJL) (H-2b/s), and A/J (H-2a). Soluble GAT did not stimulate development of GAT-specific PFC responses in cultures of spleen cells from nonresponder mice, SJL (H-2s), B10.S (H-2s), and A.SW (H-2s). GAT-MBSA stimulated development of IgG GAT-specific PFC responses in cultures of spleen cells from both responder and nonresponder strains of mice. These data correlate precisely with data obtained by measuring the in vivo responses of responder and nonresponder strains of mice to GAT and GAT-MBSA by serological techniques. Therefore, this in vitro system can effectively be used as a model to study the cellular events regulated by histocompatibility-linked immune response genes.

Therapy of Autoimmune Diseases with Antibody to Immune Response Gene Products or to T-Cell Surface Markers

1986 ◽  
Vol 475 (1 Autoimmunity) ◽  
pp. 274-284 ◽  
Author(s):  
LAWRENCE STEINMAN ◽  
MATTHEW K. WALDOR ◽  
SCOTT S. ZAMVIL ◽  
MAE LIM ◽  
LEANORE HERZENBERG ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Cell Surface ◽  
Autoimmune Diseases ◽  
Immune Response Gene ◽  
Surface Markers ◽  
Gene Products ◽  
Cell Surface Markers ◽  
Response Gene
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