Huntington Mice Demonstrate Diminished Pain Response in Inflammatory Pain Model

2018 ◽  
Vol 126 (2) ◽  
pp. 661-669 ◽  
Author(s):  
Ya-Chi Lin ◽  
Hung-Tsung Hsiao ◽  
Sheng-Nan Wu ◽  
Yen-Chin Liu
Keyword(s):  
Inflammatory Pain ◽  
Pain Response ◽  
Pain Model

scholarly journals Purinergic ATP triggers moxibustion-induced local anti-nociceptive effect on inflammatory pain model

2021 ◽  
Author(s):  
Hai-Yan Yin ◽  
Ya-Peng Fan ◽  
Juan Liu ◽  
Dao-Tong Li ◽  
Jing Guo ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Inflammatory Pain ◽  
Analgesic Effect ◽  
Intramuscular Injection ◽  
High Performance ◽  
Atp Hydrolysis ◽  
Purinergic Signalling ◽  
Pain Model ◽  
Speed Up

AbstractPurinergic signalling adenosine and its A1 receptors have been demonstrated to get involved in the mechanism of acupuncture (needling therapy) analgesia. However, whether purinergic signalling would be responsible for the local analgesic effect of moxibustion therapy, the predominant member in acupuncture family procedures also could trigger analgesic effect on pain diseases, it still remains unclear. In this study, we applied moxibustion to generate analgesic effect on complete Freund’s adjuvant (CFA)-induced inflammatory pain rats and detected the purine released from moxibustioned-acupoint by high-performance liquid chromatography (HPLC) approach. Intramuscular injection of ARL67156 into the acupoint Zusanli (ST36) to inhibit the breakdown of ATP showed the analgesic effect of moxibustion was increased while intramuscular injection of ATPase to speed up ATP hydrolysis caused a reduced moxibustion-induced analgesia. These data implied that purinergic ATP at the location of ST36 acupoint is a potentially beneficial factor for moxibustion-induced analgesia.

The antinociceptive effects of magnesium sulfate and MK-801 in visceral inflammatory pain model: The role of NO/cGMP/K+ATP pathway

2015 ◽  
Vol 53 (11) ◽  
pp. 1621-1627 ◽  
Author(s):  
Sonja Vuckovic ◽  
Dragana Srebro ◽  
Katarina Savic Vujovic ◽  
Milica Prostran
Keyword(s):  
Magnesium Sulfate ◽  
Inflammatory Pain ◽  
Pain Model ◽  
Mk 801 ◽  
Antinociceptive Effects

scholarly journals Effect of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles on chronic inflammatory pain model in rats

2009 ◽  
Vol 616 (1-3) ◽  
pp. 91-100 ◽  
Author(s):  
Patricia D. Sauzem ◽  
Gabriela da S. Sant'Anna ◽  
Pablo Machado ◽  
Marta M.M.F. Duarte ◽  
Juliano Ferreira ◽  
...  
Keyword(s):  
Inflammatory Pain ◽  
Pain Model ◽  
Chronic Inflammatory Pain

Role of PPARα and PPARγ in Mediating the Analgesic Properties of Ibuprofen in vivo and the Effects of Dual PPARα/γ Activation in Inflammatory Pain Model in the Rat

2016 ◽  
Vol 12 (8) ◽  
pp. 812-820 ◽  
Author(s):  
Mohammad Alsalem ◽  
Ahmad Altarifi ◽  
Heba Kalbouneh ◽  
Heba Al- Zer ◽  
Belal Azab ◽  
...  
Keyword(s):  
Inflammatory Pain ◽  
Pain Model

scholarly journals Morphine Antinociception Restored by Use of Methadone in the Morphine-Resistant Inflammatory Pain State

2020 ◽  
Vol 11 ◽  
Author(s):  
Chizuko Watanabe ◽  
Asami Komiyama ◽  
Masaru Yoshizumi ◽  
Shinobu Sakurada ◽  
Hirokazu Mizoguchi
Keyword(s):  
Opioid Receptors ◽  
Inflammatory Pain ◽  
Antinociceptive Effect ◽  
Thermal Hyperalgesia ◽  
Expression Level ◽  
Pain Model ◽  
Mk 801 ◽  
Antinociceptive Effects ◽  
Pain State ◽  
Intraperitoneal Treatment

The antinociceptive effect of methadone in the morphine-resistant inflammatory pain state was described in the paw-withdrawal test using the complete Freund’s adjuvant (CFA)-induced mouse inflammatory pain model. After intraplantar (i.pl.) injection of CFA, thermal hyperalgesia was observed in the ipsilateral paw. The antinociceptive effects of subcutaneous (s.c.) injection of morphine, fentanyl, and oxycodone against thermal hyperalgesia in the inflammatory pain state were reduced in the ipsilateral paw 7 days after CFA pretreatment. On the contrary, the antinociceptive effect of s.c. injection of methadone was maintained in the ipsilateral paw 7 days after CFA pretreatment. The suppressed morphine antinociception in the CFA model mice was bilaterally restored following s.c. treatment with methadone 20 min prior to or 3 days after CFA pretreatment. The suppressed morphine antinociception was also bilaterally restored by intraperitoneal treatment with MK-801 30 min prior to CFA pretreatment; however, the s.c. injection of morphine 30 min prior to CFA pretreatment failed to restore the suppressed morphine antinociception in the CFA model mice. The expression level of mRNA for µ-opioid receptors 7 days after i.pl. pretreatment was not significantly changed by i.pl. pretreatment with CFA or s.c. pretreatment with methadone. In conclusion, methadone is extremely effective against thermal hyperalgesia in the morphine-resistant inflammatory pain state, and restores suppressed morphine antinociception in the inflammatory pain state without altering the expression level of mRNA for µ-opioid receptors.

NEONATAL PAIN MODULATES IN ADOLESCENT RATS THE ANTINOCICEPTIVE EFFECTS OF FLUOXETINE AND BUSPIRONE ADMINISTRATED TO THEIR DEPRESSIVE DAMS DURING GESTATION

2020 ◽  
Author(s):  
Irina P Butkevich ◽  
Viktor A Mikhailenko ◽  
Elena A Vershinina
Keyword(s):  
Inflammatory Pain ◽  
Time Course ◽  
Antinociceptive Effect ◽  
Later Life ◽  
Pain Response ◽  
Neonatal Pain ◽  
Antinociceptive Effects ◽  
Prenatally Stressed ◽  
Adolescent Rats ◽  
Depressed Mothers

Abstract: Previously, we have shown that the administration of a selective serotonin reuptake inhibitor fluoxetine or a 5-HT1A receptor agonist buspirone to stressed rats during gestation causes in the offspring alleviation of formalin-induced pain, strengthened by prenatal stress. We have also found that neonatal inflammatory pain strengthens formalin-induced pain in prenatally unstressed rats in later life. In the present study we investigated the effect of neonatal inflammatory pain on the time-course of the biphasic pain response in the formalin test in prenatally stressed adolescent rats of both sexes to evaluate whether neonatal pain affects the antinociceptive properties of these drugs administered to their depressed mothers during gestation. Our findings demonstrate that neonatal pain modulates in prenatally stressed rats the antinociceptive effect of fluoxetine and buspirone depending on the level of organization of pain response in the CNS, the phase of the time-course of the formalin-induced pain, and sex.

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