Steroid Hormone Receptors in Meningiomas of Chinese Patients

Neurosurgery ◽  
1989 ◽  
Vol 25 (4) ◽  
pp. 541-545 ◽  
Author(s):  
Liang-Shong Lee ◽  
Chin-Wen Chi ◽  
Tai-Jay Chang ◽  
Min-Deh Chou ◽  
Hsiu-Chih Liu ◽  
...  
Keyword(s):  
Malignant Lymphoma ◽  
Glucocorticoid Receptors ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Progesterone Receptors ◽  
Tyrosine Aminotransferase ◽  
Intracranial Tumor ◽  
Steroid Hormone Receptors ◽  
Chinese Patients ◽  
Anaplastic Ependymoma

Abstract Meningioma is a hormone-related intracranial tumor. Brain tumor samples were collected from 32 Chinese patients, 20 of whom had meningiomas. Estrogen receptors were present in 6 of 17 meningiomas, 1 hemangioblastoma, 1 gemistocytic astrocytoma, and 1 neurilemoma. Of the 26 samples assayed for progesterone receptors, measurable bindings were found in 14 of 17 meningiomas, 1 of 2 astrocytomas, 1 malignant lymphoma, 1 hemangioblastoma, 1 ganglioglioma, 1 glioblastoma multiforme, 1 anaplastic ependymoma, 1 small cell sarcoma, and 1 neurilemoma. Androgen receptors were found in 8 of 19 meningiomas, but not in the 11 other brain tumors examined. Measurable glucocorticoid receptors were found in 15 of 19 meningiomas, 1 malignant lymphoma, 1 hemangioblastoma, 2 craniopharyngiomas, 1 neurilemoma, 1 of 2 glioblastomas, and 1 of 2 astrocytomas. Of the 10 samples examined for tyrosine aminotransferase activity, measurable enzyme activity was found in 7 of the 8 meningiomas, but not in the single hemangioblastoma nor in the single craniopharyngioma. In accordance with other published studies, the results from this study also suggest that the growth of meningiomas may be regulated by hormones, and that the role steroid hormones and their receptors play in the meningioma is worthy of further investigation.

scholarly journals Differential In Vivo Regulation of Steroid Hormone Receptor Activation by Cdc37p

1997 ◽  
Vol 8 (12) ◽  
pp. 2501-2509 ◽  
Author(s):  
Albert E. Fliss ◽  
Yifang Fang ◽  
Frank Boschelli ◽  
Avrom J. Caplan
Keyword(s):  
Glucocorticoid Receptors ◽  
Hormone Receptors ◽  
Androgen Receptors ◽  
Steroid Hormone ◽  
Receptor Activation ◽  
Steroid Hormone Receptors ◽  
Yeast Cells ◽  
Steroid Hormone Receptor ◽  
Restrictive Temperature

The CDC37 gene is essential for the activity of p60v-src when expressed in yeast cells. Since the activation pathway for p60v-src and steroid hormone receptors is similar, the present study analyzed the hormone-dependent transactivation by androgen receptors and glucocorticoid receptors in yeast cells expressing a mutant version of the CDC37gene. In this mutant, hormone-dependent transactivation by androgen receptors was defective at both permissive and restrictive temperatures, although transactivation by glucocorticoid receptors was mildly defective only at the restrictive temperature. Cdc37p appears to function via the androgen receptor ligand-binding domain, although it does not influence receptor hormone-binding affinity. Models for Cdc37p regulation of steroid hormone receptors are discussed.

Immunohistochemical localization of intracellular progesterone and glucocorticoid receptors in the rabbit lung

1994 ◽  
Vol 142 (2) ◽  
pp. 311-316 ◽  
Author(s):  
I Camacho-Arroyo ◽  
A Ruiz ◽  
A Gamboa-Domínguez ◽  
G Pérez-Palacios ◽  
M A Cerbón
Keyword(s):  
Glucocorticoid Receptors ◽  
Hormone Receptors ◽  
Progesterone Receptors ◽  
Cell Types ◽  
Immunohistochemical Localization ◽  
Alveolar Epithelial Cells ◽  
Steroid Hormone Receptors ◽  
Polymorphonuclear Leucocytes ◽  
Rabbit Lung ◽  
Oestradiol Treatment

Abstract We have determined the presence and distribution of intracellular progesterone receptors (PRs) and glucocorticoid receptors (GRs) in the lung of adult female rabbits using immunohistochemistry. The effects of ovariectomy and administration of oestradiol benzoate (10 μg for 3 consecutive days) upon PR and GR immunoreactivity were also studied. The results demonstrated the presence of both steroid hormone receptors in the female rabbit lung. PR and GR immunoreactivity was predominantly nuclear and located in alveolar epithelial cells and various interstitial cells such as polymorphonuclear leucocytes. Tissue distribution of both receptors was similar in all cases. Oestradiol treatment induced a marked increase in the number of PR immunoreactive cells compared with intact and ovariectomized female animals. Neither ovariectomy nor oestradiol treatment modified the number of GR immunoreactive cells. The presence and localization of intracellular PRs and GRs in several lung cell types suggest that they may play an important role in mediating the effects of progesterone and glucocorticoids in various physiological processes in the rabbit lung. The data also indicated an oestrogen regulation of PRs in the rabbit lung. Journal of Endocrinology (1994) 142, 311–316

Immunohistochemical assessment of progesterone, oestrogen and glucocorticoid receptors in bovine placentomes during pregnancy, induced parturition, and after birth with or without retention of fetal membranes

Reproduction ◽  
2000 ◽  
pp. 351-360 ◽  
Author(s):  
A Boos ◽  
J Kohtes ◽  
A Stelljes ◽  
H Zerbe ◽  
HH Thole
Keyword(s):  
Caesarean Section ◽  
Connective Tissue ◽  
Glucocorticoid Receptors ◽  
Hormone Receptors ◽  
Post Partum ◽  
Progesterone Receptors ◽  
Steroid Hormone Receptors ◽  
Fetal Membranes ◽  
Oestrogen Receptors ◽  
Tissue Cells

Steroid hormones play an important role in placental development. However, the exact cellular site of hormone action has not been evaluated in bovine placentomes. Thus, the present immunohistochemical study was designed to assess the distribution of progesterone receptors, oestrogen receptors and glucocorticoid receptors in bovine placentomes. Tissue specimens were obtained from cows at slaughter and from cattle during pre-term Caesarean section 27 h after prostaglandin administration, immediately after spontaneous parturition and from cattle that had retained the fetal membranes. Specific antibodies were used for receptor demonstration in tissue sections. Progesterone receptors were only detected in maternal connective tissue cells, whereas oestrogen receptors were also present in maternal crypt epithelium. At specific sites, both receptor immunoreactivities remained constant or changed significantly during pregnancy, were generally higher during Caesarean section and decreased post partum, but were less pronounced in cattle that released the fetal membranes than in those that retained the fetal membranes. Glucocorticoid receptors were evident in fetal connective tissue cells as well as in fetal and maternal blood vessels. Maternal crypt epithelial cells showed increasing immunoreactivities for glucocorticoid receptors during pregnancy. Receptor immunoreactivities tended to be lower after spontaneous parturition than during Caesarean section; these results were significant for progesterone and oestrogen receptors in animals that released the fetal membranes but not for those that retained the fetal membranes. The results indicate that in bovine placentome steroid hormone receptors are distributed in patterns that are specific to the type of cell, the stage of pregnancy and the tissue location, implying highly specific modulation of placental metabolism. Retention of the fetal membranes is reflected by altered placental receptor states at parturition.

scholarly journals Interaction of oestrogen and progesterone receptors with specific subfractions of laying-hen oviduct chromatin

1984 ◽  
Vol 217 (1) ◽  
pp. 309-316 ◽  
Author(s):  
N Massol ◽  
M C Lebeau ◽  
E E Baulieu
Keyword(s):  
Progesterone Receptor ◽  
Oestrogen Receptor ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Progesterone Receptors ◽  
Steroid Hormone Receptors ◽  
Target Tissue ◽  
Low Salt ◽  
High Concentrations

Salt (NaCl)-extracted nuclear oestrogen receptor from hen oviduct was incubated with salt-depleted oviduct chromatin and dialysed to low salt. The oestrogen receptor (re)associated with chromatin to form a 13-14S-sedimenting fraction, as found in ‘native’ chromatin, and saturation of this interaction was obtained for very low receptor concentrations (approx. 0.04 nM). Similarly, purified progesterone receptor from chick oviduct cytosol associated with depleted chromatin to form an 11-12S-sedimenting fraction, as in ‘native’ chromatin; this interaction tended towards saturation for much higher concentrations of progesterone receptor (approx. 8 nM) than that observed for oestrogen receptor. When the two receptors were incubated with depleted chromatin from hen kidney or erythrocytes, their s values were as for oviduct chromatin. However, no saturation of these interactions was seen, even for high concentrations of receptor. Steroid-hormone receptors can therefore bind in vitro to particular subfractions of non-target-tissue chromatin, but with a much lower affinity than to target-tissue chromatin.

GnRH agonist (buserelin) up regulates estrogen receptor α mRNA but not estrogen receptor β and progesterone receptor mRNA in bovine endometrium in vitro

2009 ◽  
Vol 89 (4) ◽  
pp. 467-473 ◽  
Author(s):  
R Singh ◽  
T Pretheeban ◽  
R Rajamahendran
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptors ◽  
Gnrh Agonist ◽  
Luteal Phase ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Progesterone Receptors ◽  
Gonadotropin Releasing Hormone ◽  
Steroid Hormone Receptors ◽  
Releasing Hormone

The local modulatory role of gonadotropin releasing hormone (GnRH), gonadotropin releasing hormone receptor (GnRH-R) system in regulating steroid hormone receptors at the endometrial level is still not known. Estrogen and progesterone maintain uterine functions by acting through their corresponding receptors; estrogen receptors (ERα and ERβ) and progesterone receptors (PR). We recently demonstrated GnRH-R in bovine endometrium and find the co-existence of GnRH and steroid hormone receptors in endometrium as interesting. Our objective was to determine the effect of a GnRH agonist (buserelin), on the expression of ERα, ERβ, and PR messenger RNA (mRNA) in bovine endometrium. Reproductive tracts were collected from slaughtered cows at a local abattoir, and endometrial explants were treated with buserelin (0, 200, 500, 1000 ng mL-1 respectively), GnRH antagonist-antide (500 ng mL-1) and antide + buserelin (500+200 ng mL-1) for 6 h and stored at -80°C for RNA extraction. Two micrograms of total RNA was subjected to reverse transcription polymerase chain reaction, PCR products electrophoresed (2% agrose gel); visualized and statistically analyzed. The results showed that buserelin (200 ng mL-1) increased the expression of ERα in the luteal phase endometrium. In addition, the expression of endometrial ERα was greater during the follicular than luteal phase. This up regulation of ERα mRNA in luteal phase endometrium suggests that GnRH administration may influence pregnancy in bovines. Key words: GnRH, bovine, endometrium, estrogen receptors, progesterone receptors

Steroid hormone receptors in meningiomas of Chinese patients

Neurosurgery ◽  
1989 ◽  
pp. 541 ◽  
Author(s):  
L S Lee ◽  
C W Chi ◽  
T J Chang ◽  
M D Chou ◽  
H C Liu ◽  
...  
Keyword(s):  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Chinese Patients
Sign in / Sign up

Export Citation Format

Share Document