RELATIONSHIP OF THE MET ALLELE OF THE BRAIN-DERIVED NEUROTROPHIC FACTOR VAL66MET POLYMORPHISM TO MEMORY AFTER ANEURYSMAL SUBARACHNOID HEMORRHAGE

Neurosurgery ◽  
2008 ◽  
Vol 63 (2) ◽  
pp. 198-203 ◽  
Author(s):  
Juhani Vilkki ◽  
Jaakko Lappalainen ◽  
Seppo Juvela ◽  
Katarzyna Kanarek ◽  
Juha A. Hernesniemi ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Neurotrophic Factor ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Brain Derived Neurotrophic Factor ◽  
Val66met Polymorphism ◽  
Relationship Of ◽  
The Brain

Chronic stress and brain-derived neurotrophic factor

2021 ◽  
Vol 19 (2) ◽  
pp. 19-27
Author(s):  
A. V. DUBOVAYA ◽  
◽  
S. Ya. IAROSHENKO ◽  
O. A. PRILUTSKAYA ◽  
◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Signal Transmission ◽  
Active Agent ◽  
Brain Derived Neurotrophic Factor ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain ◽  
Pituitary Adrenal Axis ◽  
Transmission Information ◽  
Class Representative

The article discusses the influence of stress on the development of nervous tissue, in particular, on the synthesis of neurotrophins (by the example of the brain-derived neurotrophic factor (BDNF), as the most studied class representative). The biological functions of BDNF are discussed as well as its influence on neuroplasticity and the mechanisms by which the protection of neurons is carried out. The article covers the relationship of the stress-implementing system (hypothalamic-pituitary-adrenal axis) and its main active agent (cortisol) with the BDNF synthesis system at its various levels: from the inhibition of mRNA formation to the mechanisms of postsynaptic signal transmission. Information is also provided on changes of BDNF levels due to the maternal deprivation. Epigenetic changes under the influence of glucocorticoids are also reported. However, it is not only glucocorticoids that alter the functioning of the neurotrophin system. The article provides examples of the reverse effect, enabling to consider neurotrophins as a substance with an anti-stress function. In conclusion, the authors give examples of activities that, according to research, can stimulate the synthesis of neurotrophic factor in the brain.

Meta-Analysis of the Brain-Derived Neurotrophic Factor Gene (BDNF) Val66Met Polymorphism in Anxiety Disorders and Anxiety-Related Personality Traits

2008 ◽  
Vol 58 (3-4) ◽  
pp. 163-170 ◽  
Author(s):  
Alessandra Frustaci ◽  
Gino Pozzi ◽  
Francesco Gianfagna ◽  
Lamberto Manzoli ◽  
Stefania Boccia
Keyword(s):  
Anxiety Disorders ◽  
Personality Traits ◽  
Neurotrophic Factor ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Val66met Polymorphism ◽  
Factor Gene ◽  
The Brain ◽  
Related Personality

scholarly journals Association Between Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Methamphetamine Use Disorder: A Meta-Analysis

2020 ◽  
Vol 11 ◽  
Author(s):  
Li He ◽  
Yanhui Liao ◽  
Qiuxia Wu ◽  
Tieqiao Liu
Keyword(s):  
Neurotrophic Factor ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Current Data ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Val66met Polymorphism ◽  
Asian Populations ◽  
Bdnf Val66met Polymorphism ◽  
Relationship Of

Background: Several studies had examined the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and methamphetamine (METH) use disorder, whereas the results were conflicting. The aim of this study was to conduct a meta-analysis to achieve a pooled effect size of the association between BDNF Val66Met polymorphism and METH use disorder.Methods: Literature searches were conducted in PubMed, EMBASE, and Cochrane Library up to July, 2020. All relevant studies on the relationship of BDNF Val66Met polymorphism and METH addiction were retrieved. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated in the dominant, recessive, co-dominant, and allele model to appraise the association.Results: Seven case–control studies with a total of 2,204 subjects (956 METH-dependent cases and 1,248 healthy controls) were included in this meta-analysis. The results showed a significant correlation between BDNF Val66Met polymorphism and METH dependence in overall population under different genetic models. However, subgroup analysis indicated that the association only existed in Han Chinese but not in other Asian populations.Conclusion: Although the current data indicate that BDNF Val66Met polymorphism might be a potential genetic factor for METH use disorder, more researches are needed to prove its role in different populations.

scholarly journals Pain catastrophizing is associated with the Val66Met polymorphism of the brain-derived neurotrophic factor in fibromyalgia

2020 ◽  
Vol 60 (1) ◽  
Author(s):  
Camila Fernanda da Silveira Alves ◽  
Wolnei Caumo ◽  
Joana Morez Silvestri ◽  
Maxciel Zortea ◽  
Vinicius Souza dos Santos ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Pain Catastrophizing ◽  
Brain Derived Neurotrophic Factor ◽  
Val66met Polymorphism ◽  
The Brain

scholarly journals Association Between the Brain-derived Neurotrophic Factor Val66Met Polymorphism and Overweight/Obesity in Pediatric Population

2017 ◽  
Vol 48 (7) ◽  
pp. 599-608 ◽  
Author(s):  
José Darío Martínez-Ezquerro ◽  
Mario Enrique Rendón-Macías ◽  
Gerardo Zamora-Mendoza ◽  
Jacobo Serrano-Meneses ◽  
Beatriz Rosales-Rodríguez ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Pediatric Population ◽  
Brain Derived Neurotrophic Factor ◽  
Val66met Polymorphism ◽  
The Brain
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