Chronic stress and brain-derived neurotrophic factor

2021 ◽  
Vol 19 (2) ◽  
pp. 19-27
Author(s):  
A. V. DUBOVAYA ◽  
◽  
S. Ya. IAROSHENKO ◽  
O. A. PRILUTSKAYA ◽  
◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Signal Transmission ◽  
Active Agent ◽  
Brain Derived Neurotrophic Factor ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain ◽  
Pituitary Adrenal Axis ◽  
Transmission Information ◽  
Class Representative

The article discusses the influence of stress on the development of nervous tissue, in particular, on the synthesis of neurotrophins (by the example of the brain-derived neurotrophic factor (BDNF), as the most studied class representative). The biological functions of BDNF are discussed as well as its influence on neuroplasticity and the mechanisms by which the protection of neurons is carried out. The article covers the relationship of the stress-implementing system (hypothalamic-pituitary-adrenal axis) and its main active agent (cortisol) with the BDNF synthesis system at its various levels: from the inhibition of mRNA formation to the mechanisms of postsynaptic signal transmission. Information is also provided on changes of BDNF levels due to the maternal deprivation. Epigenetic changes under the influence of glucocorticoids are also reported. However, it is not only glucocorticoids that alter the functioning of the neurotrophin system. The article provides examples of the reverse effect, enabling to consider neurotrophins as a substance with an anti-stress function. In conclusion, the authors give examples of activities that, according to research, can stimulate the synthesis of neurotrophic factor in the brain.

Relationship between levels of physical activity and brain derived neurotrophic factor in peripheral blood of monozygotic twins

2020 ◽  
Vol 16 (4) ◽  
pp. 319-324
Author(s):  
J.P. Neto ◽  
D. Santos da Silva ◽  
I.R. Vital da Silva ◽  
J. Thill ◽  
D. Pochmann ◽  
...  
Keyword(s):  
Physical Activity ◽  
Neurotrophic Factor ◽  
Monozygotic Twins ◽  
Brain Derived Neurotrophic Factor ◽  
Blood Collection ◽  
Physically Active ◽  
Mz Twins ◽  
The Relationship ◽  
The Brain ◽  
Activity Questionnaire

Studies involving monozigotic (MZ) twins are of great importance for the understanding of genetic and environmental influences without the development of individual pathologies and pathways associated with lifestyle. In this context, discordance has recently been suggested in the levels of the brain-derived neurotrophic factor (BDNF) in MZ twins, which may be associated with the practice of physical activity (PA). The objective was to verify the relationship between the peripheral levels of BDNF and PA in MZ twins. This transversal and quantitative study included 11 pairs of MZ twins that answered the International Physical Activity Questionnaire (IPAQ), a brief anamnesis and were submitted to a blood collection (15 ml) for BDNF levels analysis, measured through ELISA kit according to the manufacturer’s instructions. The study was approved by the Ethics Committee of Centro Universitário Metodista IPA (no. 1.746.954). There was no statistically significant relationship between BDNF and PA levels in sedentary and physically active MZ twins (P=0.431). PA practice does not seem to influence BDNF levels in these individuals.

The Association Between Physical Activity With Cognitive Function and Brain-Derived Neurotrophic Factor in People With Parkinson’s Disease: A Pilot Study

2017 ◽  
Vol 25 (4) ◽  
pp. 646-652 ◽  
Author(s):  
Hanan Khalil ◽  
Mahmoud A. Alomari ◽  
Omar Khabour ◽  
Aya Al-Hieshan ◽  
Jawad A. Bajwa
Keyword(s):  
Cognitive Function ◽  
Neurotrophic Factor ◽  
Cognitive Assessment ◽  
Brain Derived Neurotrophic Factor ◽  
Physical Capacity ◽  
Walk Distance ◽  
Future Studies ◽  
Relationship Of ◽  
The Relationship ◽  
Serum Bdnf

The objective of this study was to examine the effect of physical capacity on the relationship of brain-derived neurotrophic factor (BDNF) with cognitive function in people with PD. For this study, serum BDNF levels were measured in 29 PD participants and 30 healthy controls. Cognitive function was assessed using the Montreal Cognitive Assessment (MOCA) scale. Physical capacity was evaluated using the 6-min walk distance (6-MWD). Participants were categorized into low or high physical capacity group according to their 50th percentile 6-MWD. It was found that MOCA total score correlated with serum BDNF level (r = .44, P = .012) in the entire PD sample. This correlation remained significant only in the low physical capacity group (r = .62; P = .03) but not in the high physical capacity group (r = .31; P = .22). It was concluded that the relationship of BDNF with cognitive function might be dependent on physical capacity. The results are preliminary, thus future studies are needed to confirm these findings.

Polymeric Nanoparticles for Brain Drug Delivery - A Review

2020 ◽  
Vol 21 (9) ◽  
pp. 649-660
Author(s):  
Subashini Raman ◽  
Syed Mahmood ◽  
Ayah R. Hilles ◽  
Md Noushad Javed ◽  
Motia Azmana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Preparation Methods ◽  
Brain Drug Delivery ◽  
Polymeric Nanoparticle ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain

Background: Blood-brain barrier (BBB) plays a most hindering role in drug delivery to the brain. Recent research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the brain. Currently, polymeric nanoparticle is extensively involved in many therapies for spatial and temporal targeted areas delivery. Methods: We did a non-systematic review, and the literature was searched in Google, Science Direct and PubMed. An overview is provided for the formulation of polymeric nanoparticles using different methods, effect of surface modification on the nanoparticle properties with types of polymeric nanoparticles and preparation methods. An account of different nanomedicine employed with therapeutic agent to cross the BBB alone with biodistribution of the drugs. Results: We found that various types of polymeric nanoparticle systems are available and they prosper in delivering the therapeutic amount of the drug to the targeted area. The effect of physicochemical properties on nanoformulation includes change in their size, shape, elasticity, surface charge and hydrophobicity. Surface modification of polymers or nanocarriers is also vital in the formulation of nanoparticles to enhance targeting efficiency to the brain. Conclusion: More standardized methods for the preparation of nanoparticles and to assess the relationship of surface modification on drug delivery. While the preparation and its output like drug loading, particle size, and charge, permeation is always conflicted, so it requires more attention for the acceptance of nanoparticles for brain delivery.

scholarly journals The relationship of morphometric changes of the brain with IL-6 levels, systemic inflammation and immune disturbances in the patients with schizophrenia

2021 ◽  
Vol 190 ◽  
pp. 553-559
Author(s):  
Irina K. Malashenkova ◽  
Vadim L. Ushakov ◽  
Sergey A. Krynskiy ◽  
Daniil P. Ogurtsov ◽  
Nikita A. Khailov ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain
Sign in / Sign up

Export Citation Format

Share Document