scholarly journals Eyes Absent, a key repressor of polar cell fate during Drosophila oogenesis

Development ◽  
2002 ◽  
Vol 129 (23) ◽  
pp. 5377-5388 ◽  
Author(s):  
J. Bai
Keyword(s):  
Cell Fate ◽  
Eyes Absent ◽  
Drosophila Oogenesis ◽  
Polar Cell

fringeandNotchspecify polar cell fate duringDrosophilaoogenesis

Development ◽  
2001 ◽  
Vol 128 (12) ◽  
pp. 2243-2253 ◽  
Author(s):  
Muriel Grammont ◽  
Kenneth D. Irvine
Keyword(s):  
Cell Fate ◽  
Null Allele ◽  
Somatic Cells ◽  
Ectopic Expression ◽  
Notch Receptor ◽  
Drosophila Oogenesis ◽  
Early Stages ◽  
Polar Cell ◽  
Hypomorphic Alleles ◽  
Notch Activation

fringe encodes a glycosyltransferase that modulates the ability of the Notch receptor to be activated by its ligands. We describe studies of fringe function during early stages of Drosophila oogenesis. Animals mutant for hypomorphic alleles of fringe contain follicles with an incorrect number of germline cells, which are separated by abnormally long and disorganized stalks. Analysis of clones of somatic cells mutant for a null allele of fringe localizes the requirement for fringe in follicle formation to the polar cells, and demonstrates that fringe is required for polar cell fate. Clones of cells mutant for Notch also lack polar cells and the requirement for Notch in follicle formation appears to map to the polar cells. Ectopic expression of fringe or of an activated form of Notch can generate an extra polar cell. Our results indicate that fringe plays a key role in positioning Notch activation during early oogenesis, and establish a function for the polar cells in separating germline cysts into individual follicles.

scholarly journals The Hippo pathway controls polar cell fate through Notch signaling during Drosophila oogenesis

2011 ◽  
Vol 357 (2) ◽  
pp. 370-379 ◽  
Author(s):  
Hsi-Ju Chen ◽  
Chi-Ming Wang ◽  
Tsu-Wei Wang ◽  
Gwo-Jen Liaw ◽  
Ta-Hsing Hsu ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Cell Fate ◽  
Hippo Pathway ◽  
Drosophila Oogenesis ◽  
Polar Cell ◽  
The Hippo Pathway

scholarly journals A two-step Notch-dependant mechanism controls the selection of the polar cell pair in Drosophila oogenesis

Development ◽  
2010 ◽  
Vol 137 (16) ◽  
pp. 2703-2711 ◽  
Author(s):  
C. Vachias ◽  
J.-L. Couderc ◽  
M. Grammont
Keyword(s):  
Drosophila Oogenesis ◽  
Cell Pair ◽  
Polar Cell ◽  
Selection Of

Decoding vectorial information from a gradient: sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye

Development ◽  
1999 ◽  
Vol 126 (24) ◽  
pp. 5725-5738 ◽  
Author(s):  
A. Tomlinson ◽  
G. Struhl
Keyword(s):  
High Activity ◽  
Cell Fate ◽  
Photoreceptor Cells ◽  
The Other ◽  
Cell Fate Decision ◽  
Planar Polarity ◽  
Genetic Mosaics ◽  
Polar Cell ◽  
Drosophila Eye ◽  
Fate Decision

The Drosophila eye is composed of several hundred ommatidia that can exist in either of two chiral forms, depending on position: ommatidia in the dorsal half of the eye adopt one chiral form, whereas ommatidia in the ventral half adopt the other. Chirality appears to be specified by a polarizing signal with a high activity at the interface between the two halves (the ‘equator’), which declines in opposite directions towards the dorsal and ventral poles. Here, using genetic mosaics, we show that this polarizing signal is decoded by the sequential use of two receptor systems. The first depends on the seven-transmembrane receptor Frizzled (Fz) and distinguishes between the two members of the R3/R4 pair of presumptive photoreceptor cells, predisposing the cell that is located closer to the equator and having higher Fz activity towards the R3 photoreceptor fate and the cell further away towards the R4 fate. This bias is then amplified by subsequent interactions between the two cells mediated by the receptor Notch (N) and its ligand Delta (Dl), ensuring that the equatorial cell becomes the R3 photoreceptor while the polar cell becomes the R4 photoreceptor. As a consequence of this reciprocal cell fate decision, the R4 cell moves asymmetrically relative to the R3 cell, initiating the appropriate chiral pattern of the remaining cells of the ommatidium.

Signaling by the TGF-beta homolog decapentaplegic functions reiteratively within the network of genes controlling retinal cell fate determination in Drosophila

Development ◽  
1999 ◽  
Vol 126 (5) ◽  
pp. 935-943 ◽  
Author(s):  
R. Chen ◽  
G. Halder ◽  
Z. Zhang ◽  
G. Mardon
Keyword(s):  
Cell Fate ◽  
Retinal Cell ◽  
Cell Fate Determination ◽  
Tgf Beta ◽  
Eyes Absent ◽  
Fate Determination ◽  
Sine Oculis ◽  
Retinal Determination ◽  
Interactive Network ◽  
Distinct Cell

Retinal cell fate determination in Drosophila is controlled by an interactive network of genes, including eyeless, eyes absent, sine oculis and dachshund. We have investigated the role of the TGF-beta homolog decapentaplegic in this pathway. We demonstrate that, during eye development, while eyeless transcription does not depend on decapentaplegic activity, the expression of eyes absent, sine oculis and dachshund are greatly reduced in a decapentaplegic mutant background. We also show that decapentaplegic signaling acts synergistically with and at multiple levels of the retinal determination network to induce eyes absent, sine oculis and dachshund expression and ectopic eye formation. These results suggest a mechanism by which a general patterning signal such as Decapentaplegic cooperates reiteratively with tissue-specific factors to determine distinct cell fates during development.

scholarly journals Expression of constitutively active Notch arrests follicle cells at a precursor stage during Drosophila oogenesis and disrupts the anterior-posterior axis of the oocyte

Development ◽  
1996 ◽  
Vol 122 (11) ◽  
pp. 3639-3650 ◽  
Author(s):  
M.K. Larkin ◽  
K. Holder ◽  
C. Yost ◽  
E. Giniger ◽  
H. Ruohola-Baker
Keyword(s):  
Cell Fate ◽  
Ovarian Follicle ◽  
Follicle Cells ◽  
Cell Fates ◽  
Drosophila Oogenesis ◽  
Cell Fate Decisions ◽  
Notch Gene ◽  
Anterior Posterior ◽  
Anterior Posterior Axis ◽  
Constitutively Active

During early development, there are numerous instances where a bipotent progenitor divides to give rise to two progeny cells with different fates. The Notch gene of Drosophila and its homologues in other metazoans have been implicated in many of these cell fate decisions. It has been argued that the role of Notch in such instances may be to maintain cells in a precursor state susceptible to specific differentiating signals. This has been difficult to prove, however, due to a lack of definitive markers for precursor identity. We here perform molecular and morphological analyses of the roles of Notch in ovarian follicle cells during Drosophila oogenesis. These studies show directly that constitutively active Notch arrests cells at a precursor stage, while the loss of Notch function eliminates this stage. Expression of moderate levels of activated Notch leads to partial transformation of cell fates, as found in other systems, and we show that this milder phenotype correlates with a prolonged, but still transient, precursor stage. We also find that expression of constitutively active Notch in follicle cells at later stages leads to a defect in the anterior-posterior axis of the oocyte.

scholarly journals Polar cell fate stimulatesWolbachiaintracellular growth

Development ◽  
2018 ◽  
Vol 145 (6) ◽  
pp. dev158097 ◽  
Author(s):  
Ajit D. Kamath ◽  
Mark A. Deehan ◽  
Horacio M. Frydman
Keyword(s):  
Cell Fate ◽  
Polar Cell

scholarly journals Castor is required for Hedgehog-dependent cell-fate specification and follicle stem cell maintenance in Drosophila oogenesis

2013 ◽  
Vol 110 (19) ◽  
pp. E1734-E1742 ◽  
Author(s):  
Y.-C. Chang ◽  
A. C.- C. Jang ◽  
C.-H. Lin ◽  
D. J. Montell
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Drosophila Oogenesis ◽  
Fate Specification ◽  
Stem Cell Maintenance ◽  
Dependent Cell ◽  
Cell Maintenance
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