scholarly journals Castor is required for Hedgehog-dependent cell-fate specification and follicle stem cell maintenance in Drosophila oogenesis

2013 ◽  
Vol 110 (19) ◽  
pp. E1734-E1742 ◽  
Author(s):  
Y.-C. Chang ◽  
A. C.- C. Jang ◽  
C.-H. Lin ◽  
D. J. Montell
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Drosophila Oogenesis ◽  
Fate Specification ◽  
Stem Cell Maintenance ◽  
Dependent Cell ◽  
Cell Maintenance

Stem Cell Fate Specification: Role of Master Regulatory Switch Transcription Factor PU.1 in Differential Hematopoiesis

2005 ◽  
Vol 14 (2) ◽  
pp. 140-152 ◽  
Author(s):  
Gurudutta U. Gangenahalli ◽  
Pallavi Gupta ◽  
Daman Saluja ◽  
Yogesh K. Verma ◽  
Vimal Kishore ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Stem Cell Fate ◽  
Fate Specification

scholarly journals Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1

Cell Reports ◽  
2022 ◽  
Vol 38 (2) ◽  
pp. 110240
Author(s):  
Yingying Han ◽  
Alvaro Villarreal-Ponce ◽  
Guadalupe Gutierrez ◽  
Quy Nguyen ◽  
Peng Sun ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Epithelial Cell ◽  
Cell Fate ◽  
Stem Cell Maintenance ◽  
Basal Epithelial Cell ◽  
Coordinate Control ◽  
Cell Maintenance

scholarly journals Molecular Mechanisms of Stem Cell Pluripotency and Cell Fate Specification

2017 ◽  
Vol 429 (10) ◽  
pp. 1439-1440
Author(s):  
Greg M. Findlay ◽  
Laurent David ◽  
Tobias A. Beyer
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Molecular Mechanisms ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Stem Cell Pluripotency

Somatic signaling mediated by fs(1)Yb is essential for germline stem cell maintenance during Drosophila oogenesis

Development ◽  
1999 ◽  
Vol 126 (9) ◽  
pp. 1833-1844 ◽  
Author(s):  
F.J. King ◽  
H. Lin
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Genomic Region ◽  
Germline Stem Cell ◽  
Germline Stem Cells ◽  
Drosophila Oogenesis ◽  
Stem Cell Maintenance ◽  
Terminal Filament ◽  
Potential Signal ◽  
Cell Maintenance

Drosophila oogenesis starts when a germline stem cell divides asymmetrically to generate a daughter germline stem cell and a cystoblast that will develop into a mature egg. We show that the fs(1)Yb gene is essential for the maintenance of germline stem cells during oogenesis. We delineate fs(1)Yb within a 6.4 kb genomic region by transgenic rescue experiments. fs(1)Yb encodes a 4.1 kb RNA that is present in the third instar larval, pupal and adult stages, consistent with its role in regulating germline stem cells during oogenesis. Germline clonal analysis shows that all fs(1)Yb mutations are soma-dependent. In the adult ovary, fs(1)Yb is specifically expressed in the terminal filament cells, suggesting that fs(1)Yb acts in these signaling cells to maintain germline stem cells. fs(1)Yb encodes a novel hydrophilic protein with no potential signal peptide or transmembrane domains, suggesting that this protein is not itself a signal but a key component of the signaling machinery for germline stem cell maintenance.

scholarly journals Stem cell fate in hypoxic root apical meristems is influenced by phytoglobin expression

2019 ◽  
Author(s):  
Mohammed M Mira ◽  
Eman A El-Khateeb ◽  
Reda M Gaafar ◽  
Abir U Igamberdiev ◽  
Robert D Hill ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Stem Cell Fate ◽  
Fate Specification ◽  
Apical Meristems ◽  
And Function

Overexpression of phytoglobin retains stem cell fate specification and function in hypoxic root apical meristems

scholarly journals MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling

Cell Reports ◽  
2021 ◽  
Vol 35 (7) ◽  
pp. 109124
Author(s):  
Hideyuki Nakashima ◽  
Keita Tsujimura ◽  
Koichiro Irie ◽  
Takuya Imamura ◽  
Cleber A. Trujillo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Neural Stem Cell ◽  
Cell Fate Specification ◽  
Stem Cell Fate ◽  
Smad Signaling ◽  
Fate Specification

scholarly journals An organoid and multi-organ developmental cell atlas reveals multilineage fate specification in the human intestine

2020 ◽  
Author(s):  
Qianhui Yu ◽  
Umut Kilik ◽  
Emily M. Holloway ◽  
Yu-Hwai Tsai ◽  
Angeline Wu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Time Course ◽  
Cell Fate Specification ◽  
Mesodermal Cell ◽  
Fate Specification ◽  
Molecular Machinery ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome ◽  
Primary Tissue

Human intestinal organoids (HIOs) generated from pluripotent stem cells provide extraordinary opportunities to explore development and disease. Here, we generate a single-cell transcriptome reference atlas from HIOs and from multiple developing human organs to quantify the specificity of HIO cell fate acquisition, and to explore alternative fates. We identify epithelium-mesenchyme interactions, transcriptional regulators involved in cell fate specification, and stem cell maturation features in the primary tissue that are recapitulated in HIOs. We use an HIO time course to reconstruct the molecular dynamics of intestinal stem cell emergence, as well as the specification of multiple mesenchyme subtypes. We find that the intestinal master regulator CDX2 correlates with distinct phases of epithelial and mesenchymal development, and CDX2 deletion perturbs the differentiation of both intestinal epithelium and mesenchyme. Collectively our data provides a comprehensive and quantitative assessment of HIO development, and illuminates the molecular machinery underlying endodermal and mesodermal cell fate specification.

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