Development of adult sensilla on the wing and notum of Drosophila melanogaster

Development ◽  
1989 ◽  
Vol 107 (2) ◽  
pp. 389-405 ◽  
Author(s):  
V. Hartenstein ◽  
J.W. Posakony
Keyword(s):  
Cell Lineage ◽  
Precursor Cell ◽  
Random Pattern ◽  
Wing Margin ◽  
After Puparium Formation ◽  
First Order ◽  
Accessory Cells ◽  
Puparium Formation ◽  
Tormogen Cell ◽  
Adult Drosophila

We have investigated the temporal pattern of appearance, cell lineage, and cytodifferentiation of selected sensory organs (sensilla) of adult Drosophila. This analysis was facilitated by the discovery that the monoclonal antibody 22C10 labels not only the neuron of the developing sensillum organ, but the accessory cells as well. The precursors of the macrochaetes and the recurved (chemosensory) bristles of the wing margin divide around and shortly after puparium formation, while those of the microchaetes and the stout and slender (mechanosensory) bristles of the wing margin divide between 9 h and 18 h after puparium formation (apf). The onset of sensillum differentiation follows the terminal precursor division within a few hours. Four of the cells in an individual microchaete organ are clonally related: A single first-order precursor cell divides to produce two second-order precursors; one of these divides into the neuron and thecogen cell, the other into the trichogen cell and tormogen cell. Along the anterior wing margin, two rounds of division generate the cells of the mechanosensory sensilla; here, no strict clonal relationship seems to exist between the cells of an individual sensillum. At the time of sensillum precursor division, many other, non-sensillum-producing cells within the notum and wing proliferate as well. This mitotic activity follows a spatially non-random pattern.

scholarly journals The development of the bristles in normal and some mutant types of Drosophila melanogaster

1942 ◽  
Vol 131 (862) ◽  
pp. 87-110 ◽  
Keyword(s):  
Drosophila Melanogaster ◽  
Single Cell ◽  
Epidermal Cells ◽  
After Puparium Formation ◽  
Puparium Formation ◽  
Tormogen Cell

This paper describes the development of the normal macro- and micro-chaetae of Drosophila , together with that of twelve mutant types. The phenotypes of twenty combinations of these genes have been studied. Each normal bristle is secreted by a single cell, the trichogen, which lies beneath a tormogen cell which secretes a socket. These bristle cells are first distinguishable in the epidermis at about 15 hr. after puparium formation, when they have already divided to form a pair, and are slightly larger than the normal epidermal cells. The secretion of the bristle proceeds most rapidly between 30 and 55 hr., during which time the bristle cells are very large and obviously highly polyploid. The socket, apparently, does not completely enclose the base of the bristle in the earliest stages. The development of the microchaetae is essentially similar to that of the macrochaetae. The actions of the twelve genes can be summarized as follows: Scute causes a primary absence of certain bristle cells, and extra-bristle-complex -41 e and hairy the presence of supernumerary groups. Split frequently causes an extra division, so that a group of four cells is formed; these may be arranged as two trichogens and two tormogens, or one trichogen and three tormogens; or the whole group may fail to reach the surface of the epithelium, when no bristle or socket is formed. Dichaete may produce an effect similar to the last-described of split , and it may also cause an extra division of the trichogen, producing a double bristle in a single socket. Hairless causes the trichogens of some bristle groups to lie level with the tormogens, and to develop like them into sockets. In Stubble the tormogens are shifted rather to one side of the trichogens, so that the bristle is less closely invested by the socket, and becomes thicker and shorter. In shaven-naked the trichogen is irregularly displaced, becoming more or less converted into a tormogen; the small bristle which may be secreted is often peculiarly fanned out at the tip, suggesting an effect of the gene on the nature of the material secreted. Spineless and morula slow down the growth of the bristle cells. Singed, forked and Bristle all affect the nature of the bristle secretion, there being some reason to suggest that the effects of Bristle and singed may be similar and different to that of forked.

scholarly journals Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage

2020 ◽  
Vol 15 (4) ◽  
pp. 883-897
Author(s):  
Akihide Takeuchi ◽  
Yuji Takahashi ◽  
Kei Iida ◽  
Motoyasu Hosokawa ◽  
Koichiro Irie ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Glial Cell ◽  
Cell Lineage ◽  
Precursor Cell ◽  
Cell Marker ◽  
Fate Specification ◽  
Glial Precursor

scholarly journals A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis

PLoS Biology ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. e3000538 ◽  
Author(s):  
Allison Jevitt ◽  
Deeptiman Chatterjee ◽  
Gengqiang Xie ◽  
Xian-Feng Wang ◽  
Taylor Otwell ◽  
...  
Keyword(s):  
Somatic Cell ◽  
Single Cell ◽  
Cell Lineage ◽  
Drosophila Ovary ◽  
Adult Drosophila ◽  
Somatic Cell Lineage

scholarly journals Ki-M7 monoclonal antibody specific for myelomonocytic cell lineage and macrophages in human.

1987 ◽  
Vol 35 (10) ◽  
pp. 1117-1126 ◽  
Author(s):  
H Kreipe ◽  
H J Radzun ◽  
M R Parwaresch ◽  
A Haislip ◽  
M L Hansmann
Keyword(s):  
Monoclonal Antibody ◽  
Oxygen Radicals ◽  
Cell Lineage ◽  
Human Monocyte ◽  
Cell Immune Response ◽  
Lymphoid Follicles ◽  
Reticulum Cells ◽  
Accessory Cells ◽  
Dendritic Reticulum Cells ◽  
Immunohistochemical Methods

We describe a new monoclonal antibody, termed Ki-M7, which is specific to human myelomonocytic cell lineage and macrophages, as tested by immunohistochemical methods. Ki-M7 recognizes an intracytoplasmic antigen of molecular weight 29,000. Ultrastructurally, the antigen is localized in the lysosome and phagosome compartments and seems to be involved in generation of oxygen radicals during the respiratory burst. Dendritic cells, such as dendritic reticulum cells of lymphoid follicles and interdigitating reticulum cells of lymphoid T-zones, considered as accessory cells of the B- and T-cell immune response, respectively, do not show any reactivity with monoclonal antibody Ki-M7. Ki-M7 seems to be an appropriate reagent to clearly differentiate between the phagocytosing and the immune accessory population of the human monocyte/macrophage system.

Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage

2000 ◽  
Vol 3 (1) ◽  
pp. 58-67 ◽  
Author(s):  
Fabrice Roegiers ◽  
Susan Younger-Shepherd ◽  
Lily Yeh Jan ◽  
Yuh Nung Jan
Keyword(s):  
Cell Lineage ◽  
Precursor Cell ◽  
Sensory Organ ◽  
Asymmetric Divisions ◽  
Sensory Organ Precursor

scholarly journals Activation of latent ribonuclease in the fat-body of fleshfly (Sarcophaga peregrina) larvae on pupation

1981 ◽  
Vol 196 (3) ◽  
pp. 699-703 ◽  
Author(s):  
Y Aoki ◽  
S Natori
Keyword(s):  
Crude Extract ◽  
Fat Body ◽  
Inhibitor Protein ◽  
After Puparium Formation ◽  
Inhibitor Complex ◽  
Puparium Formation ◽  
Fat Bodies ◽  
Third Instar Larvae

A crude extract of the fat-bodies of third-instar larvae of Sarcophaga peregrina (fleshfly) was found to contain latent RNAase (ribonuclease) consisting of RNAase and inhibitor protein that is sensitive to p-chloromercuribenzoic acid. The RNAase activity in the crude extract of fat-bodies became detectable with time after puparium formation, indicating that the inhibitor is selectively inactivated and RNAase is released from the RNAase-inhibitor complex during metamorphosis.

scholarly journals The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development

2008 ◽  
Vol 205 (5) ◽  
pp. 1187-1199 ◽  
Author(s):  
Claudia Benz ◽  
Vera C. Martins ◽  
Freddy Radtke ◽  
Conrad C. Bleul
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Lineage ◽  
Cell Types ◽  
Cell Development ◽  
Precursor Cells ◽  
Precursor Cell ◽  
Lineage Tracing ◽  
Hematopoietic Precursor ◽  
The Common

T cell development in the thymus depends on continuous colonization by hematopoietic precursors. Several distinct T cell precursors have been identified, but whether one or several independent precursor cell types maintain thymopoiesis is unclear. We have used thymus transplantation and an inducible lineage-tracing system to identify the intrathymic precursor cells among previously described thymus-homing progenitors that give rise to the T cell lineage in the thymus. Extrathymic precursors were not investigated in these studies. Both approaches show that the stream of T cell lineage precursor cells, when entering the thymus, selectively passes through the early T lineage precursor (ETP) stage. Immigrating precursor cells do not exhibit characteristics of double-negative (DN) 1c, DN1d, or DN1e stages, or of populations containing the common lymphoid precursor 2 (CLP-2) or the thymic equivalent of circulating T cell progenitors (CTPs). It remains possible that an unknown hematopoietic precursor cell or previously described extrathymic precursors with a CLP, CLP-2, or CTP phenotype feed into T cell development by circumventing known intrathymic T cell lineage progenitor cells. However, it is clear that of the known intrathymic precursors, only the ETP population contributes significant numbers of T lineage precursors to T cell development.

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