scholarly journals Drosophila Ataxin 2-binding protein 1 marks an intermediate step in the molecular differentiation of female germline cysts

Development ◽  
2010 ◽  
Vol 137 (19) ◽  
pp. 3167-3176 ◽  
Author(s):  
O. Y. Tastan ◽  
J. Z. Maines ◽  
Y. Li ◽  
D. M. Mckearin ◽  
M. Buszczak
Keyword(s):  
Binding Protein ◽  
Intermediate Step ◽  
Molecular Differentiation ◽  
Ataxin 2 ◽  
Female Germline

The RNA ‐binding protein and stress granule component ATAXIN ‐2 is expressed in mouse and human tissues associated with glaucoma pathogenesis

2021 ◽  
Author(s):  
Chad Sundberg ◽  
Monika Lakk ◽  
Sharan Paul ◽  
K. P. Figueroa ◽  
Daniel R. Scoles ◽  
...  
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Stress Granule ◽  
Human Tissues ◽  
Ataxin 2

scholarly journals Structural Basis of Binding of P-body-associated Proteins GW182 and Ataxin-2 by the Mlle Domain of Poly(A)-binding Protein

2010 ◽  
Vol 285 (18) ◽  
pp. 13599-13606 ◽  
Author(s):  
Guennadi Kozlov ◽  
Nozhat Safaee ◽  
Angelika Rosenauer ◽  
Kalle Gehring
Keyword(s):  
Binding Protein ◽  
Structural Basis ◽  
Associated Proteins ◽  
Ataxin 2

scholarly journals Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila

2010 ◽  
Vol 341 (2) ◽  
pp. 389-399 ◽  
Author(s):  
N. Usha ◽  
L.S. Shashidhara
Keyword(s):  
Binding Protein ◽  
Wing Development ◽  
Cubitus Interruptus ◽  
Ataxin 2

scholarly journals Catalytic and ligand binding properties of the FK506 binding protein FKBP12: effects of the single amino acid substitution of Tyr82 to Leu

1994 ◽  
Vol 297 (2) ◽  
pp. 365-372 ◽  
Author(s):  
M J Bossard ◽  
D J Bergsma ◽  
M Brandt ◽  
G P Livi ◽  
W K Eng ◽  
...  
Keyword(s):  
Amino Acid ◽  
Ligand Binding ◽  
Binding Protein ◽  
Single Amino Acid ◽  
Intermediate Step ◽  
Wild Type ◽  
Structural Element ◽  
Binding Properties ◽  
Gene Encoding ◽  
Fk506 Binding Protein

The binding of FK506 and rapamycin to their cytosolic receptor FKBP12 is an intermediate step in the paths leading to their potent immunosuppressive properties. One of the amino acids defining the hydrophobic binding cleft for the macrocycles is Tyr82, which is thought to form a hydrogen bond with the amide oxygens of the common pipecolyl structural element within the two macrolides. To understand better the influence of this amino acid residue in catalytic activity (cis-trans peptidyl prolyl isomerization) and ligand binding properties, a Tyr82 to Leu site-specific modification of FKBP12 was prepared, purified and characterized. Kinetic experiments have demonstrated that the Tyr82 to Leu modification has a greater effect on catalytic properties than on ligand binding affinities, a result which indicates that these inhibitors may not be binding as true transition-state analogues. In an additional test for cellular function, expression of both wild-type and mutant human FKBP12 in a strain of Saccharomyces cerevisiae rendered resistant to rapamycin by deletion of the gene encoding a cytosolic rapamycin binding protein (RPB1), the yeast homologue of FKBP12, restored wild-type drug sensitivity.

1100 ATAXIN 2-BINDING PROTEIN 1 AS A NOVEL SUSCEPTIBLE GENE FOR PRIMARY BILIARY CIRRHOSIS IN JAPANESE PATIENTS

2010 ◽  
Vol 52 ◽  
pp. S425
Author(s):  
S. Joshita ◽  
T. Umemura ◽  
S. Morita ◽  
A. Kamijo ◽  
M. Komatsu ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Binding Protein ◽  
Japanese Patients ◽  
Biliary Cirrhosis ◽  
Ataxin 2 ◽  
Susceptible Gene

scholarly journals Roles of Ataxin-2 in Pathological Cascades Mediated by TAR DNA-binding Protein 43 (TDP-43) and Fused in Sarcoma (FUS)

2012 ◽  
Vol 287 (49) ◽  
pp. 41310-41323 ◽  
Author(s):  
Yoshihiro Nihei ◽  
Daisuke Ito ◽  
Norihiro Suzuki
Keyword(s):  
Dna Binding ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Fused In Sarcoma ◽  
Ataxin 2

scholarly journals Ataxin 2-binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis inDrosophila melanogaster

Development ◽  
2017 ◽  
Vol 144 (5) ◽  
pp. 905-915 ◽  
Author(s):  
Jay Prakash Shukla ◽  
Girish Deshpande ◽  
L. S. Shashidhara
Keyword(s):  
Notch Signaling ◽  
Binding Protein ◽  
Positive Regulator ◽  
Ataxin 2 ◽  
Context Specific

scholarly journals The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4

2016 ◽  
Vol 27 (20) ◽  
pp. 3052-3064 ◽  
Author(s):  
Megan M. Gnazzo ◽  
Eva-Maria E. Uhlemann ◽  
Alex R. Villarreal ◽  
Masaki Shirayama ◽  
Eddie G. Dominguez ◽  
...  
Keyword(s):  
Cell Division ◽  
Posttranscriptional Regulation ◽  
Direct Evidence ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Spindle Midzone ◽  
Ataxin 2 ◽  
Temporal And Spatial

The spindle midzone harbors both microtubules and proteins necessary for furrow formation and the completion of cytokinesis. However, the mechanisms that mediate the temporal and spatial recruitment of cell division factors to the spindle midzone and midbody remain unclear. Here we describe a mechanism governed by the conserved RNA-binding protein ATX-2/Ataxin-2, which targets and maintains ZEN-4 at the spindle midzone. ATX-2 does this by regulating the amount of PAR-5 at mitotic structures, particularly the spindle, centrosomes, and midbody. Preventing ATX-2 function leads to elevated levels of PAR-5, enhanced chromatin and centrosome localization of PAR-5–GFP, and ultimately a reduction of ZEN-4–GFP at the spindle midzone. Codepletion of ATX-2 and PAR-5 rescued the localization of ZEN-4 at the spindle midzone, indicating that ATX-2 mediates the localization of ZEN-4 upstream of PAR-5. We provide the first direct evidence that ATX-2 is necessary for cytokinesis and suggest a model in which ATX-2 facilitates the targeting of ZEN-4 to the spindle midzone by mediating the posttranscriptional regulation of PAR-5.

scholarly journals A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium

2009 ◽  
Vol 46 (9) ◽  
pp. 614-616 ◽  
Author(s):  
G Zhai ◽  
J B J van Meurs ◽  
G Livshits ◽  
I Meulenbelt ◽  
A M Valdes ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Binding Protein ◽  
Genome Wide Association ◽  
Hand Osteoarthritis ◽  
Genome Wide ◽  
A Genome ◽  
Ataxin 2
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