scholarly journals EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells

Development ◽  
2018 ◽  
Vol 145 (14) ◽  
pp. dev157149 ◽  
Author(s):  
Le Zhang ◽  
Sandrine Ettou ◽  
Myda Khalid ◽  
Mary Taglienti ◽  
Dhawal Jain ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Polycomb Group ◽  
Nephron Differentiation ◽  
Nephron Progenitor

scholarly journals Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q− polycythemia vera

Blood ◽  
2010 ◽  
Vol 116 (15) ◽  
pp. 2812-2821 ◽  
Author(s):  
Fabiana Perna ◽  
Nadia Gurvich ◽  
Ruben Hoya-Arias ◽  
Omar Abdel-Wahab ◽  
Ross L. Levine ◽  
...  
Keyword(s):  
Polycythemia Vera ◽  
Progenitor Cells ◽  
Cell Fate ◽  
Myeloproliferative Neoplasms ◽  
Erythroid Differentiation ◽  
Polycomb Group ◽  
Human Cord Blood ◽  
Hematopoietic Stem ◽  
Cell Fate Decisions ◽  
Cd34 Cells

Abstract L3MBTL1, the human homolog of the Drosophila L(3)MBT polycomb group tumor suppressor gene, is located on chromosome 20q12, within the common deleted region identified in patients with 20q deletion-associated polycythemia vera, myelodysplastic syndrome, and acute myeloid leukemia. L3MBTL1 is expressed within hematopoietic CD34+ cells; thus, it may contribute to the pathogenesis of these disorders. To define its role in hematopoiesis, we knocked down L3MBTL1 expression in primary hematopoietic stem/progenitor (ie, CD34+) cells isolated from human cord blood (using short hairpin RNAs) and observed an enhanced commitment to and acceleration of erythroid differentiation. Consistent with this effect, overexpression of L3MBTL1 in primary hematopoietic CD34+ cells as well as in 20q− cell lines restricted erythroid differentiation. Furthermore, L3MBTL1 levels decrease during hemin-induced erythroid differentiation or erythropoietin exposure, suggesting a specific role for L3MBTL1 down-regulation in enforcing cell fate decisions toward the erythroid lineage. Indeed, L3MBTL1 knockdown enhanced the sensitivity of hematopoietic stem/progenitor cells to erythropoietin (Epo), with increased Epo-induced phosphorylation of STAT5, AKT, and MAPK as well as detectable phosphorylation in the absence of Epo. Our data suggest that haploinsufficiency of L3MBTL1 contributes to some (20q−) myeloproliferative neoplasms, especially polycythemia vera, by promoting erythroid differentiation.

scholarly journals A Synthetic Niche for Nephron Progenitor Cells

2015 ◽  
Vol 34 (2) ◽  
pp. 229-241 ◽  
Author(s):  
Aaron C. Brown ◽  
Sree Deepthi Muthukrishnan ◽  
Leif Oxburgh
Keyword(s):  
Progenitor Cells ◽  
Nephron Progenitor

scholarly journals New Insights into Fuel Choices of Nephron Progenitor Cells

2017 ◽  
Vol 28 (11) ◽  
pp. 3133-3135
Author(s):  
Leif Oxburgh ◽  
Clifford J. Rosen
Keyword(s):  
Progenitor Cells ◽  
Nephron Progenitor

scholarly journals Correction: A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Qiuyu Guo ◽  
Albert D Kim ◽  
Bin Li ◽  
Andrew Ransick ◽  
Helena Bugacov ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Progenitor Cells ◽  
Transcription Factor Binding ◽  
Factor Binding ◽  
Target Sites ◽  
Nephron Progenitor

Comprehensive analysis of chromatin signature and transcriptome uncovers functional lncRNAs expressed in nephron progenitor cells

2019 ◽  
Vol 1862 (1) ◽  
pp. 58-70 ◽  
Author(s):  
Masaki Nishikawa ◽  
Shunsuke Yuri ◽  
Hiroshi Kimura ◽  
Naomi Yanagawa ◽  
Morgan Hamon ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Comprehensive Analysis ◽  
Chromatin Signature ◽  
Nephron Progenitor

scholarly journals Conditional ablation of the prorenin receptor in nephron progenitor cells results in developmental programming of hypertension

2018 ◽  
Vol 6 (7) ◽  
pp. e13644 ◽  
Author(s):  
Renfang Song ◽  
Laura Kidd ◽  
Adam Janssen ◽  
Ihor V. Yosypiv
Keyword(s):  
Progenitor Cells ◽  
Developmental Programming ◽  
Prorenin Receptor ◽  
Nephron Progenitor

scholarly journals Premature differentiation of nephron progenitor cell and dysregulation of gene pathways critical to kidney development in a model of preterm birth

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aleksandra Cwiek ◽  
Masako Suzuki ◽  
Kimberly deRonde ◽  
Mark Conaway ◽  
Kevin M. Bennett ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Progenitor Cells ◽  
Kidney Development ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Neonatal Morbidity ◽  
Expression Of Genes ◽  
Nephron Progenitor ◽  
Lower Expression ◽  
Nephrogenic Zone

AbstractPreterm birth is a leading cause of neonatal morbidity. Survivors have a greater risk for kidney dysfunction and hypertension. Little is known about the molecular changes that occur in the kidney of individuals born preterm. Here, we demonstrate that mice delivered two days prior to full term gestation undergo premature cessation of nephrogenesis, resulting in a lower glomerular density. Kidneys from preterm and term groups exhibited differences in gene expression profiles at 20- and 27-days post-conception, including significant differences in the expression of fat-soluble vitamin-related genes. Kidneys of the preterm mice exhibited decreased proportions of endothelial cells and a lower expression of genes promoting angiogenesis compared to the term group. Kidneys from the preterm mice also had altered nephron progenitor subpopulations, early Six2 depletion, and altered Jag1 expression in the nephrogenic zone, consistent with premature differentiation of nephron progenitor cells. In conclusion, preterm birth alone was sufficient to shorten the duration of nephrogenesis and cause premature differentiation of nephron progenitor cells. These candidate genes and pathways may provide targets to improve kidney health in preterm infants.

Nephron Progenitor Cells

2014 ◽  
pp. 293-331 ◽  
Author(s):  
Raphael Kopan ◽  
Shuang Chen ◽  
Melissa Little
Keyword(s):  
Progenitor Cells ◽  
Nephron Progenitor
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