scholarly journals Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells

Development ◽  
2018 ◽  
Vol 145 (23) ◽  
pp. dev169136 ◽  
Author(s):  
Yuichi Shima ◽  
Kanako Miyabayashi ◽  
Tetsuya Sato ◽  
Mikita Suyama ◽  
Yasuyuki Ohkawa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Leydig Cells ◽  
Fetal Leydig Cells

Exogenous androgens reduce the expression of INSL3, a hormone involved in normal testicular descent, in fetal Leydig cells

2014 ◽  
Author(s):  
W Colin Duncan ◽  
Fiona Connolly ◽  
Lyndsey Boswell ◽  
Graeme Burt ◽  
Alan S McNeilly ◽  
...  
Keyword(s):  
Leydig Cells ◽  
Testicular Descent ◽  
Fetal Leydig Cells

Distinctive functioning of STARD1 in the fetal Leydig cells compared to adult Leydig and adrenal cells. Impact of Hedgehog signaling via the primary cilium.

2021 ◽  
pp. 111265
Author(s):  
Anbarasi Kothandapani ◽  
Michele Campaigne Larsen ◽  
Jinwoo Lee ◽  
Joan S. Jorgensen ◽  
Colin R. Jefcoate
Keyword(s):  
Primary Cilium ◽  
Leydig Cells ◽  
Hedgehog Signaling ◽  
Adrenal Cells ◽  
Fetal Leydig Cells

scholarly journals Previously claimed male germline stem cells from porcine testis are actually progenitor Leydig cells

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Yinshan Bai ◽  
Cui Zhu ◽  
Meiying Feng ◽  
Hengxi Wei ◽  
Li Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Leydig Cells ◽  
Germline Stem Cells ◽  
Male Germline ◽  
Male Germline Stem Cells ◽  
Porcine Testis

scholarly journals Comparison of biotechnological culture of hypoxia-conditioned rat mesenchymal stem cells with conventional in vitro culture of normoxia-conditioned rat mesenchymal stem cells for testicular failure therapy with low libido in rats

2019 ◽  
Vol 12 (6) ◽  
pp. 916-924 ◽  
Author(s):  
Erma Safitri ◽  
Mas'ud Hariadi
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Functional Outcome ◽  
Leydig Cells ◽  
Control Group ◽  
Spermatogenic Cells ◽  
Hematopoietic Stem ◽  
T1 And T2 ◽  
Testicular Failure

Aim: Biotechnological culture of hypoxia-conditioned (CH) rat mesenchymal stem cells (rMSC-CH) for testicular failure therapy with low libido improves the functional outcome of the testicle for producing spermatogenic cells and repairs Leydig cells in rats (Rattus norvegicus). Materials and Methods: In the first group (T1), rats with testicular failure and low libido were injected with normoxia-conditioned (CN) rMSCs (21% oxygen); in the second group (T2), rats with testicular failure and low libido were injected with rMSC-CH (1% oxygen); in the negative control group (T–), rats with normal testis were injected with 0.1 mL phosphate-buffered saline (PBS); and in the sham group (TS), rats with testicular failure and low libido were injected with 0.1 mL of PBS. Results: Vascular endothelial growth factor expression, as the homing signal, in the groups T2, T–, T1, and TS was 2.00±0.5%, 2.95±0.4%, 0.33±0.48%, and 0±0%, respectively. The number of cluster of differentiation (CD)34+ and CD45+ cells in the groups T– and TS was <20%, whereas that in T1 and T2 groups was >30% and >80%, respectively, showing the mobilization of hematopoietic stem cells (HSCs). The number of spermatogenic cells (spermatogonia, primary spermatocytes, secondary spermatocytes, and spermatid) decreased significantly (p<0.05) in TS compared with that in T–, T1, and T2, whereas that in T2 did not show a significant (p>0.05) decrease compared to that in T–. The improvement in libido, based on the number of Leydig cells producing the hormone testosterone for libido expression, did not increase in T1, whereas T2 was able to maintain the number of Leydig cells significantly compared to that between TS and T1. Conclusion: rMSC-CH culture for testicular failure with low libido showed improvement in the functional outcome of the testicle and in repairing Leydig cells.

scholarly journals Leydig cells: From stem cells to aging

2009 ◽  
Vol 306 (1-2) ◽  
pp. 9-16 ◽  
Author(s):  
Haolin Chen ◽  
Ren-Shan Ge ◽  
Barry R. Zirkin
Keyword(s):  
Stem Cells ◽  
Leydig Cells

CYTOPLASMIC FILAMENTS IN FETAL LEYDIG CELLS

1982 ◽  
Vol 383 (1 The Cell Biol) ◽  
pp. 486-487 ◽  
Author(s):  
Lauri J. Pelliemi ◽  
Martin Dym ◽  
Jorma Paranko
Keyword(s):  
Leydig Cells ◽  
Cytoplasmic Filaments ◽  
Fetal Leydig Cells

scholarly journals Mamld1 Deficiency Significantly Reduces mRNA Expression Levels of Multiple Genes Expressed in Mouse Fetal Leydig Cells but Permits Normal Genital and Reproductive Development

Endocrinology ◽  
2012 ◽  
Vol 153 (12) ◽  
pp. 6033-6040 ◽  
Author(s):  
Mami Miyado ◽  
Michiko Nakamura ◽  
Kenji Miyado ◽  
Ken-ichirou Morohashi ◽  
Shinichiro Sano ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Leydig Cells ◽  
Reproductive Development ◽  
Expression Levels ◽  
Multiple Genes ◽  
Mrna Expression Levels ◽  
Fetal Leydig Cells

Immunolocalisation of androgen receptor to interstitial cells in fetal rat testes and to mesenchymal and epithelial cells of associated ducts

1995 ◽  
Vol 147 (2) ◽  
pp. 285-293 ◽  
Author(s):  
G Majdic ◽  
M R Millar ◽  
P T K Saunders
Keyword(s):  
Androgen Receptor ◽  
Epithelial Cells ◽  
Leydig Cells ◽  
Interstitial Cells ◽  
Mesenchymal Cells ◽  
Wolffian Duct ◽  
Nuclear Staining ◽  
Mullerian Duct ◽  
Fetal Rat ◽  
Fetal Leydig Cells

Abstract Androgens are required for the development of male internal and external genitalia. Androgen action is mediated by an intracellular receptor which acts as a transcription factor following activation by ligand binding. The aim of the present study was to define the time of appearance of androgen receptor (AR) in the male fetal rat gonad using immunohistochemistry. Intact fetuses (days 13·5–16·5) or testicular tissue (days 16·5–20·5 and days 3–7 postnatal) were fixed in Bouins' solution and processed into paraffin wax. On day 16·5 nuclear AR were present in mesenchymal cells surrounding the Wolffian duct but those around the Mullerian duct were receptor negative. During the following day (17–18) the abundance of nuclear staining increased, becoming detectable in the epithelial cells of the Wolffian ducts. Within the testis some nuclear staining was apparent at day 17 but was confined to interstitial cells surrounding the seminiferous cords. As development of the testis proceeded the abundance of nuclear AR in peritubular and elongated mesenchymal cells increased. AR were not detected in fetal Leydig cells expressing 3β-hydroxysteroid dehydrogenase nor in the ovaries or associated ducts of female fetuses at the same ages. In conclusion, in the rat we have found AR expression detectable by immunohistochemistry in mesonephric mesenchyme to be confined to that underlying the Wolffian ducts and to be absent from the area around the degenerating Mullerian duct. On and after day 17 of gestation AR is present in Wolffian duct epithelial cell nuclei and within the testis it is confined to peritubular and interstitial cells which may have migrated from the mesonephros. Fetal Leydig cells were receptor negative. Within the seminiferous cords AR in Sertoli cells remained low until after birth and some perinuclear staining was detected in cells thought to be gonocytes. We believe this to be the first report of immunolocalisation of AR to fetal testicular interstitial cells. Journal of Endocrinology (1995) 147, 285–293

Luteinizing hormone-dependent activity and luteinizing hormone-independent differentiation of rat fetal Leydig cells

2001 ◽  
Vol 172 (1-2) ◽  
pp. 193-202 ◽  
Author(s):  
Stéphanie Migrenne ◽  
Catherine Pairault ◽  
Chrystèle Racine ◽  
Gabriel Livera ◽  
Annette Géloso ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Leydig Cells ◽  
Dependent Activity ◽  
Fetal Leydig Cells
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