Regeneration and growth control in Nereis

Development ◽  
1967 ◽  
Vol 18 (1) ◽  
pp. 67-77
Author(s):  
D. W. Golding
Keyword(s):  
Wound Healing ◽  
Intact Animal ◽  
Growth Control ◽  
Growth Zone ◽  
Anterior Border ◽  
Early Stages ◽  
Proliferation And Differentiation ◽  
Number Of Segments

The annelid body, as typified by that of Nereis, consists of a presegmental prostomium, a number of segments, and a postsegmental pygidium. The larval trochosphere is unsegmented. Once proliferation of segments has started, their number increases steadily throughout most of the life of the adrenal, though the rate of proliferation declines (Clark & Clark, 1962). New segments are added posteriorly by proliferation and differentiation of tissue comprising the growth zone, which forms the anterior border of the pygidium. After loss of the pygidium and posterior segments, wound healing is followed by the formation of a new growth zone. Amoebocyte migration (Stephan-Dubois, 1955,1956,1958) and dedifferentiation of cells adjacent to the level of transection (Herlant-Meewis & Nokin, 1962) are important in the early stages of regeneration. Proliferation of segments recommences and they are produced more rapidly than they are in the intact animal, as will be shown later.

A histological study of the early stages of cutaneous wound healing in lizards inin vivo andin vitro

1972 ◽  
Vol 180 (2) ◽  
pp. 175-185 ◽  
Author(s):  
P. F. A. Maderson ◽  
S. I. Roth
Keyword(s):  
Wound Healing ◽  
Histological Study ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound ◽  
Early Stages

Controlled release of KGF-2 for regulation of wound healing by KGF-2 complexed with “lotus seedpod surface-like” porous microsphere

2021 ◽  
Author(s):  
Hao Pan ◽  
Changcan Shi ◽  
Rongshuai Yang ◽  
Guanghui Xi ◽  
Chao Lu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Controlled Release ◽  
Growth Factor ◽  
Normal Tissue ◽  
Keratinocyte Growth Factor ◽  
Tissue Structure ◽  
Effective Strategy ◽  
Proliferation And Differentiation ◽  
Porous Microsphere ◽  
Lotus Seedpod

Keratinocyte growth factor-2 (KGF-2) plays a remarkable role in maintaining normal tissue structure and promoting wound healing by regulation the proliferation and differentiation of keratinocyte. As an effective strategy, KGF-2...

scholarly journals The Effect of a Polyester Nanofibrous Membrane with a Fibrin-Platelet Lysate Coating on Keratinocytes and Endothelial Cells in a Co-Culture System

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 457
Author(s):  
Andreu Blanquer ◽  
Jana Musilkova ◽  
Elena Filova ◽  
Johanka Taborska ◽  
Eduard Brynda ◽  
...  
Keyword(s):  
Wound Healing ◽  
Endothelial Cells ◽  
Chronic Wounds ◽  
Human Keratinocytes ◽  
Skin Wound ◽  
Platelet Lysate ◽  
Therapeutic Approaches ◽  
Skin Wound Healing ◽  
New Therapeutic Approaches ◽  
Proliferation And Differentiation

Chronic wounds affect millions of patients worldwide, and it is estimated that this number will increase steadily in the future due to population ageing. The research of new therapeutic approaches to wound healing includes the development of nanofibrous meshes and the use of platelet lysate (PL) to stimulate skin regeneration. This study considers a combination of a degradable electrospun nanofibrous blend of poly(L-lactide-co-ε-caprolactone) and poly(ε-caprolactone) (PLCL/PCL) membranes (NF) and fibrin loaded with various concentrations of PL aimed at the development of bioactive skin wound healing dressings. The cytocompatibility of the NF membranes, as well as the effect of PL, was evaluated in both monocultures and co-cultures of human keratinocytes and human endothelial cells. We determined that the keratinocytes were able to adhere on all the membranes, and their increased proliferation and differentiation was observed on the membranes that contained fibrin with at least 50% of PL (Fbg + PL) after 14 days. With respect to the co-culture experiments, the membranes with fibrin with 20% of PL were observed to enhance the metabolic activity of endothelial cells and their migration, and the proliferation and differentiation of keratinocytes. The results suggest that the newly developed NF combined with fibrin and PL, described in the study, provides a promising dressing for chronic wound healing purposes.

Proliferative Activity, Apoptosis, and Histogenesis in the Early Stages of Rat Tooth Extraction Wound Healing

2007 ◽  
Vol 186 (2) ◽  
pp. 104-111 ◽  
Author(s):  
Hirotaka Sato ◽  
Yasunori Takeda
Keyword(s):  
Wound Healing ◽  
Proliferative Activity ◽  
Tooth Extraction ◽  
Early Stages

Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring

1995 ◽  
Vol 108 (3) ◽  
pp. 985-1002 ◽  
Author(s):  
M. Shah ◽  
D.M. Foreman ◽  
M.W. Ferguson
Keyword(s):  
Wound Healing ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Collagen I ◽  
Tgf Beta ◽  
Early Stages ◽  
Collagen Iii ◽  
Exogenous Addition ◽  
Growth Factor Beta ◽  
Beta 2

Exogenous addition of neutralising antibody to transforming growth factor-beta 1,2 to cutaneous wounds in adult rodents reduces scarring. Three isoforms of transforming growth factor-beta (1, 2 and 3) have been identified in mammals. We investigated the isoform/isoforms of TGF-beta responsible for cutaneous scarring by: (i) reducing specific endogenous TGF-beta isoforms by exogenous injection of isoform specific neutralising antibodies; and (ii) increasing the level of specific TGF-beta isoforms by exogenous infiltration into the wound margins. Exogenous addition of neutralising antibody to TGF-beta 1 plus neutralising antibody to TGF-beta 2 reduced the monocyte and macrophage profile, neovascularisation, fibronectin, collagen III and collagen I deposition in the early stages of wound healing compared to control wounds. Treatment with neutralising antibodies to TGF-betas 1 and 2 markedly improved the architecture of the neodermis to resemble that of normal dermis and reduced scarring while the control wounds healed with scar formation. Exogenous addition of neutralising antibody to TGF-beta 1 alone also reduced the monocyte and macrophage profile, fibronectin, collagen III and collagen I deposition compared to control wounds. However, treatment with neutralising antibody to TGF-beta 1 alone only marginally reduced scarring. By contrast, wounds treated with neutralising antibody to TGF-beta 2 alone did not differ from control wounds. Interestingly, exogenous addition of the TGF-beta 3 peptide also reduced the monocyte and macrophage profile, fibronectin, collagen I and collagen III deposition in the early stages of wound healing and markedly improved the architecture of the neodermis and reduced scarring. By contrast, wounds treated with either TGF-beta 1 or with TGF-beta 2 had more extracellular matrix deposition in the early stages of wound healing but did not differ from control wounds in the final quality of scarring. This study clearly demonstrates isoform specific differences in the role of TGF-betas in wound healing and cutaneous scarring. TGF-beta 1 and TGF-beta 2 are implicated in cutaneous scarring. This study also suggests a novel therapeutic use of exogenous recombinant, TGF-beta 3 as an anti-scarring agent.

Electrospun tilapia collagen nanofibers accelerating wound healing via inducing keratinocytes proliferation and differentiation

2016 ◽  
Vol 143 ◽  
pp. 415-422 ◽  
Author(s):  
Tian Zhou ◽  
Nanping Wang ◽  
Yang Xue ◽  
Tingting Ding ◽  
Xin Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Proliferation And Differentiation

Studies of Growth Factor and Matrix Proteinase Activities During Early Stages of Wound Healing

1995 ◽  
pp. 239-243 ◽  
Author(s):  
W. Y. J. Chen ◽  
A. A. Rogers
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Early Stages

Transcriptional analysis of scar-free wound healing during early stages of tail regeneration in the green anole lizard, Anolis carolinensis

2020 ◽  
Vol 7 ◽  
pp. 100025 ◽  
Author(s):  
Cindy Xu ◽  
Elizabeth D. Hutchins ◽  
Minami A. Tokuyama ◽  
Jeanne Wilson-Rawls ◽  
Kenro Kusumi
Keyword(s):  
Wound Healing ◽  
Anolis Carolinensis ◽  
Transcriptional Analysis ◽  
Tail Regeneration ◽  
Anole Lizard ◽  
Early Stages ◽  
Green Anole ◽  
Green Anole Lizard

scholarly journals Nod-Like Receptor Protein-3 Inflammasome Plays an Important Role during Early Stages of Wound Healing

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119106 ◽  
Author(s):  
Eileen M. Weinheimer-Haus ◽  
Rita E. Mirza ◽  
Timothy J. Koh
Keyword(s):  
Wound Healing ◽  
Receptor Protein ◽  
Early Stages
Sign in / Sign up

Export Citation Format

Share Document