scholarly journals Gut innervation and enteric nervous system development: a spatial, temporal and molecular tour de force

Development ◽  
2021 ◽  
Vol 148 (3) ◽  
pp. dev182543
Author(s):  
Yi-Ning Kang ◽  
Candice Fung ◽  
Pieter Vanden Berghe
Keyword(s):  
Nervous System ◽  
System Development ◽  
Three Dimensional ◽  
Nervous System Development ◽  
Neuroimmune Interactions ◽  
Intrinsic Innervation ◽  
Gut Function ◽  
Extrinsic Innervation ◽  
And Function ◽  
Enteric Nervous System Development

ABSTRACTDuring embryonic development, the gut is innervated by intrinsic (enteric) and extrinsic nerves. Focusing on mammalian ENS development, in this Review we highlight how important the different compartments of this innervation are to assure proper gut function. We specifically address the three-dimensional architecture of the innervation, paying special attention to the differences in development along the longitudinal and circumferential axes of the gut. We review recent information about the formation of both intrinsic innervation, which is fairly well-known, as well as the establishment of the extrinsic innervation, which, despite its importance in gut-brain signaling, has received much less attention. We further discuss how external microbial and nutritional cues or neuroimmune interactions may influence development of gut innervation. Finally, we provide summary tables, describing the location and function of several well-known molecules, along with some newer factors that have more recently been implicated in the development of gut innervation.

scholarly journals Expression and function of tenascin‐C during colorectal enteric nervous system development

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Nandor Nagy ◽  
Sophie Akbareian ◽  
Casey Steiger ◽  
David Molnar ◽  
Csilla Barad ◽  
...  
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
System Development ◽  
Nervous System Development ◽  
Tenascin C ◽  
And Function ◽  
Enteric Nervous System Development

scholarly journals Neurons interact with the microbiome: an evolutionary-informed perspective

Neuroforum ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Christoph Giez ◽  
Alexander Klimovich ◽  
Thomas C. G. Bosch
Keyword(s):  
Nervous System ◽  
Neural Circuits ◽  
Current Knowledge ◽  
System Development ◽  
Nervous System Development ◽  
Comprehensive Understanding ◽  
Strategic Model ◽  
Microbe Interactions ◽  
Host Microbe Interactions ◽  
And Function

Abstract Animals have evolved within the framework of microbes and are constantly exposed to diverse microbiota. Microbes colonize most, if not all, animal epithelia and influence the activity of many organs, including the nervous system. Therefore, any consideration on nervous system development and function in the absence of the recognition of microbes will be incomplete. Here, we review the current knowledge on the nervous systems of Hydra and its role in the host–microbiome communication. We show that recent advances in molecular and imaging methods are allowing a comprehensive understanding of the capacity of such a seemingly simple nervous system in the context of the metaorganism. We propose that the development, function and evolution of neural circuits must be considered in the context of host–microbe interactions and present Hydra as a strategic model system with great basic and translational relevance for neuroscience.

scholarly journals Changes in Nicotinic Neurotransmission during Enteric Nervous System Development

2015 ◽  
Vol 35 (18) ◽  
pp. 7106-7115 ◽  
Author(s):  
J. P. P. Foong ◽  
C. S. Hirst ◽  
M. M. Hao ◽  
S. J. McKeown ◽  
W. Boesmans ◽  
...  
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
System Development ◽  
Nervous System Development ◽  
Enteric Nervous System Development

scholarly journals Testing the Ret and Sema3d genetic interaction in mouse enteric nervous system development

2017 ◽  
Vol 26 (10) ◽  
pp. 1811-1820 ◽  
Author(s):  
Ashish Kapoor ◽  
Dallas R. Auer ◽  
Dongwon Lee ◽  
Sumantra Chatterjee ◽  
Aravinda Chakravarti
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Genetic Interaction ◽  
System Development ◽  
Nervous System Development ◽  
Enteric Nervous System Development

Pain and immunity

2021 ◽  
pp. 67-71
Author(s):  
Simon Beggs
Keyword(s):  
Nervous System ◽  
Immune System ◽  
Early Life ◽  
System Development ◽  
Later Life ◽  
Nervous System Development ◽  
Neuronal Function ◽  
Neuronal Homeostasis ◽  
Neuroimmune Interactions ◽  
The Central Nervous System

The central nervous system (CNS) and immune system are inextricably linked. The complexity of their interactions is still being unraveled, but the list of processes mediated wholly or in part by neuroimmune interactions continues to grow. The influence of the immune system is crucial for normal nervous system development both pre- and postnatally, for maintaining neuronal homeostasis in the mature CNS and modulating synaptic plasticity. Aberrations in this crosstalk have been implicated in many neurodevelopmental and psychiatric disorders. It is not feasible to explore neuronal function at any point in the lifespan, in health or disease, without considering the influence of the immune system. In the adult animal it is now well established that pain chronicity is maintained by immune influence upon the neuronal nociceptive system, although, fascinatingly, there is now evidence for a marked sexual dimorphism in how the immune and nervous systems interact. This holds true for pain in early life, where the two still-developing systems provide a very different environment to mediate nociception and pain. Of particular interest is how the immune system and sex interact to early life painful events to prime pain responses in later life.

scholarly journals A loss-of-function homozygous mutation in DDX59 implicates a conserved DEAD-box RNA helicase in nervous system development and function

2017 ◽  
Vol 39 (2) ◽  
pp. 187-192 ◽  
Author(s):  
Vincenzo Salpietro ◽  
Stephanie Efthymiou ◽  
Andreea Manole ◽  
Bhawana Maurya ◽  
Sarah Wiethoff ◽  
...  
Keyword(s):  
Nervous System ◽  
System Development ◽  
Rna Helicase ◽  
Nervous System Development ◽  
Homozygous Mutation ◽  
Loss Of Function ◽  
Dead Box ◽  
And Function
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