scholarly journals Juvenile hormone acts through FoxO to promote Cdc2 and Orc5 transcription for polyploidy-dependent vitellogenesis

Development ◽  
2020 ◽  
Vol 147 (18) ◽  
pp. dev188813
Author(s):  
Zhongxia Wu ◽  
Qiongjie He ◽  
Baojuan Zeng ◽  
Haodan Zhou ◽  
Shutang Zhou
Keyword(s):  
Juvenile Hormone ◽  
Egg Production ◽  
Large Scale ◽  
Origin Recognition Complex ◽  
Fat Body ◽  
Locusta Migratoria ◽  
Upstream Region ◽  
Migratory Locust ◽  
Phosphatase 2A ◽  
Underlying Mechanisms

ABSTRACTVitellogenin (Vg) is a prerequisite for egg production and embryonic development after ovipositioning in oviparous animals. In many insects, juvenile hormone (JH) promotes fat body cell polyploidization for the massive Vg synthesis required for the maturation of multiple oocytes, but the underlying mechanisms remain poorly understood. Using the migratory locust Locusta migratoria as a model system, we report here that JH induces the dephosphorylation of Forkhead box O transcription factor (FoxO) through a signaling cascade including leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase 2A (PP2A). JH promotes PP2A activity via LCMT1-mediated methylation, consequently triggering FoxO dephosphorylation. Dephosphorylated FoxO binds to the upstream region of two endocycle-related genes, cell-division-cycle 2 (Cdc2) and origin-recognition-complex subunit 5 (Orc5), and activates their transcription. Depletion of FoxO, Cdc2 or Orc5 results in blocked polyploidization of fat body cells, accompanied by markedly reduced Vg expression, impaired oocyte maturation and arrested ovarian development. The results suggest that JH acts via LCMT1-PP2A-FoxO to regulate Cdc2 and Orc5 expression, and to enhance ploidy of fat body cells in preparation for the large-scale Vg synthesis required for synchronous maturation of multiple eggs.

scholarly journals Isolation and structure of a novel charged member of the red–pigment-concentrating hormone-adipokinetic hormone family of peptides isolated from the corpora cardiaca of the blowfly Phormia terraenovae (Diptera)

1990 ◽  
Vol 269 (2) ◽  
pp. 309-313 ◽  
Author(s):  
G Gäde ◽  
H Wilps ◽  
R Kellner
Keyword(s):  
Periplaneta Americana ◽  
Fat Body ◽  
Locusta Migratoria ◽  
Reversed Phase ◽  
American Cockroach ◽  
Red Pigment ◽  
Adipokinetic Hormone ◽  
Migratory Locust ◽  
Corpora Cardiaca ◽  
Adipokinetic Hormone Family

A hypertrehalosaemic neuropeptide from the corpora cardiaca of the blowfly Phormia terraenovae has been isolated by reversed-phase h.p.l.c., and its primary structure was determined by pulsed-liquid phase sequencing employing Edman chemistry after enzymically deblocking the N-terminal pyroglutamate residue. The C-terminus was also blocked, as indicated by the lack of digestion when the peptide was incubated with carboxypeptidase A. The octapeptide has the sequence pGlu-Leu-Thr-Phe-Ser-Pro-Asp-Trp-NH2 and is clearly defined as a novel member of the RPCH/AKH (red-pigment-concentrating hormone/adipokinetic hormone) family of peptides. It is the first charged member of this family to be found. The synthetic peptide causes an increase in the haemolymph carbohydrate concentration in a dose-dependent fashion in blowflies and therefore is named ‘Phormia terraenovae hypertrehalosaemic hormone’ (Pht-HrTH). In addition, receptors in the fat-body of the American cockroach (Periplaneta americana) recognize the peptide, resulting in carbohydrate elevation in the blood. However, fat-body receptors of the migratory locust (Locusta migratoria) do not recognize this charged molecule, and thus no lipid mobilization is observed in this species.

Changes in the Fat and Protein Content of the African Migratory Locust, Locusta migratoria migratorioides (R. & F.)

1952 ◽  
Vol 43 (1) ◽  
pp. 101-109 ◽  
Author(s):  
S. P. Cheu
Keyword(s):  
Body Weight ◽  
Fat Body ◽  
Locusta Migratoria ◽  
Feeding Activity ◽  
Initial Period ◽  
Adult Life ◽  
Fat Content ◽  
Migratory Locust ◽  
Locusta Migratoria Migratorioides ◽  
Rate Of Increase

The process of build-up of reserve substances in Locusta migratoria migratorioides (R. & F.) is very closely correlated with the feeding activity of the insect. Locusts attain their maximum body weight in the initial period before maturation. In the females there is one minor build-up period after each laying.As measured by the weight of faeces produced, the gregaria female consumes more food than the solitaria during development. It also has a lower rate of increase in body weight, maturation and oviposition.Locusts start to build up fat soon after the final ecdysis. The fat content reaches its maximum in the early part of adult life, and then begins to decline in both sexes of both phases.By far the greater part of the fat reserve thus built up in the gregaria female is used up before oviposition, and only a small amount goes to the making of the first egg-pod. The fat of the subsequent egg-pods (of both phases) is derived from the fat built up each time after a new egg-pod is laid.The solitaria females may mature their eggs at various stages in the development of the fat body. Those which have a longer pre-maturation period have a higher fat content.

Juvenile hormone-controlled vitellogenin synthesis in Locusta migratoria fat body

1979 ◽  
Vol 69 (1) ◽  
pp. 59-72 ◽  
Author(s):  
Thomas T. Chen ◽  
Pierre Couble ◽  
Randa Abu-Hakima ◽  
Gerard R. Wyatt
Keyword(s):  
Juvenile Hormone ◽  
Fat Body ◽  
Locusta Migratoria ◽  
Vitellogenin Synthesis

The vitellogenin receptor functionality of the migratory locust depends on its phosphorylation by juvenile hormone

2021 ◽  
Vol 118 (37) ◽  
pp. e2106908118
Author(s):  
Yu-Pu Jing ◽  
Xinpeng Wen ◽  
Lunjie Li ◽  
Shanjing Zhang ◽  
Ci Zhang ◽  
...  
Keyword(s):  
Juvenile Hormone ◽  
Periplaneta Americana ◽  
Locusta Migratoria ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Posttranslational Regulation ◽  
Lipoprotein Receptors ◽  
Migratory Locust ◽  
Vitellogenin Receptor ◽  
Oocyte Cytoplasm

Vitellogenin receptor (VgR) plays a pivotal role in ovarian vitellogenin (Vg) uptake and vertical transmission of pathogenic microbes and Wolbachia symbionts. However, the regulatory mechanisms of VgR action as an endocytic receptor and translocation from oocyte cytoplasm to the membrane remain poorly understood. Here, by using the migratory locust Locusta migratoria as a model system, we report that juvenile hormone (JH) promotes VgR phosphorylation at Ser1361 in the second EGF-precursor homology domain. A signaling cascade including GPCR, PLC, extracellular calcium, and PKC-ι is involved in JH-stimulated VgR phosphorylation. This posttranslational regulation is a prerequisite for VgR binding to Vg on the external surface of the oocyte membrane and subsequent VgR/Vg endocytosis. Acidification, a condition in endosomes, induces VgR dephosphorylation along with the dissociation of Vg from VgR. Phosphorylation modification is also required for VgR recycling from oocyte cytoplasm to the membrane. Additionally, VgR phosphorylation and its requirement for Vg uptake and VgR recycling are evolutionarily conserved in other representative insects including the cockroach Periplaneta americana and the cotton bollworm Helicoverpa armigera. This study fills an important knowledge gap of low-density lipoprotein receptors in posttranslational regulation, endocytosis, and intracellular recycling.

Argonaute 1 is indispensable for juvenile hormone mediated oogenesis in the migratory locust, Locusta migratoria

2013 ◽  
Vol 43 (9) ◽  
pp. 879-887 ◽  
Author(s):  
Jiasheng Song ◽  
Wei Guo ◽  
Feng Jiang ◽  
Le Kang ◽  
Shutang Zhou
Keyword(s):  
Juvenile Hormone ◽  
Locusta Migratoria ◽  
Migratory Locust ◽  
Argonaute 1

The influence of juvenile hormone on polyploidy and vitellogenesis in the fat body of Locusta migratoria

1981 ◽  
Vol 45 (1) ◽  
pp. 91-99 ◽  
Author(s):  
D.J. Irvine ◽  
K. Brasch
Keyword(s):  
Juvenile Hormone ◽  
Fat Body ◽  
Locusta Migratoria

scholarly journals Large-Scale Transcriptome Analysis of Retroelements in the Migratory Locust, Locusta migratoria

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e40532 ◽  
Author(s):  
Feng Jiang ◽  
Meiling Yang ◽  
Wei Guo ◽  
Xianhui Wang ◽  
Le Kang
Keyword(s):  
Transcriptome Analysis ◽  
Large Scale ◽  
Locusta Migratoria ◽  
Migratory Locust

Trehalose inhibits the release of adipokinetic hormones from the corpus cardiacum in the African migratory locust, Locusta migratoria, at the level of the adipokinetic cells

1997 ◽  
Vol 153 (2) ◽  
pp. 299-305 ◽  
Author(s):  
P C C M Passier ◽  
H G B Vullings ◽  
J H B Diederen ◽  
D J Van der Horst
Keyword(s):  
Fat Body ◽  
Locusta Migratoria ◽  
Inhibitory Effect ◽  
Dependent Manner ◽  
Corpus Cardiacum ◽  
High Concentration ◽  
High Potassium ◽  
Migratory Locust ◽  
Corpora Cardiaca

Abstract The effect of trehalose at various concentrations on the release of adipokinetic hormones (AKHs) from the adipokinetic cells in the glandular part of the corpus cardiacum of Locusta migratoria was studied in vitro. Pools of five corpora cardiaca or pools of five glandular parts of corpora cardiaca were incubated in a medium containing different concentrations of trehalose in the absence or presence of AKH-release-inducing agents. It was demonstrated that trehalose inhibits spontaneous release of AKH I in a dose-dependent manner. At a concentration of 80 mm, which is the concentration found in the hemolymph at rest, trehalose significantly decreased the release of AKH I induced by 100 μm locustatachykinin I, 10 μm 3-isobutyl-1-methylxanthine (IBMX) or high potassium concentrations. The specificity of the effect of trehalose was studied by incubating pools of corpora cardiaca with the non-hydrolyzable disaccharide sucrose or with glucose, the degradation product of trehalose, both in the presence and absence of 10 μm IBMX. Sucrose had no effect at all on the release of AKH I, whereas glucose strongly inhibited its release. The results point to the inhibitory effect of trehalose on the release of AKH I being exerted, at least partly, at the level of the adipokinetic cells, possibly after its conversion into glucose. The data presented in this study support the hypothesis that in vivo the relatively high concentration of trehalose (80 mm) at rest strongly inhibits the release of AKHs. At the onset of flight, the demand for energy substrates exceeds the amount of trehalose that can be mobilized from the fat body and consequently the trehalose concentration in the hemolymph decreases. This relieves the inhibitory effect of trehalose on the release of AKHs, which in turn mobilize lipids from the fat body. Journal of Endocrinology (1997) 153, 299–305

Sign in / Sign up

Export Citation Format

Share Document