scholarly journals Transitions in development – an interview with Kate McDole

Development ◽  
2021 ◽  
Vol 148 (23) ◽  
Author(s):  
Seema Grewal
Keyword(s):  
Molecular Biology ◽  
Mouse Embryo ◽  
Research Group ◽  
Three Dimensional ◽  
Group Leader ◽  
Mechanical Forces

Kate McDole is a Group Leader at the MRC Laboratory of Molecular Biology (LMB) in Cambridge, UK. Using the mouse embryo as a model, Kate's research group studies how mechanical forces can shape complex three-dimensional structures out of simple populations of cells. We met with Kate to find out more about her career, the challenges of setting up a lab during the pandemic, and her thoughts on mentorship and transitioning to a group leader position.

scholarly journals Why Governments Should Invest More in Fundamental Research

2019 ◽  
Vol 1 (1) ◽  
pp. 1-3
Author(s):  
Venki Ramakrishnan ◽  
Mejd Alsari
Keyword(s):  
Molecular Biology ◽  
Nobel Prize ◽  
Public Engagement ◽  
Royal Society ◽  
Scientific Research ◽  
Group Leader ◽  
Structure And Function ◽  
Science And Engineering ◽  
Fundamental Research ◽  
And Function

Venkatraman ‘Venki’ Ramakrishnan is the President of The Royal Society and Group Leader at the MRC Laboratory of Molecular Biology. In 2009 he shared the Nobel Prize in Chemistry ‘for studies of the structure and function of the ribosome’. In this interview he explains why governments should invest more in basic scientific research rather than simply on applied science and engineering. He also discusses interdisciplinarity, collaborations, and public engagement.

Effect of Position and Flow Waveform on the Fluid Mechanics of a Stenosed Human Right Coronary Artery

2001 ◽  
Author(s):  
K. B. Chandran ◽  
S. D. Ramaswamy ◽  
Y.-G. Lai ◽  
A. Wahle ◽  
M. Sonka
Keyword(s):  
Fluid Mechanics ◽  
Three Dimensional ◽  
Coronary Vessels ◽  
Mechanical Forces ◽  
Flow Waveform ◽  
Human Right ◽  
Plaque Growth ◽  
Oscillatory Shear Stress ◽  
The Relationship

Abstract Complete occlusion in any of the coronary vessels leads to a myocardial infarction. The role of fluid mechanical forces in atheroma development has been widely accepted because of preferential plaque growth at certain locations of the vessel geometry, such as a bifurcation or regions of high degrees of curvature. Areas of low and/or oscillatory shear stress have been correlated with atheroma development [1]. In order to determine the relationship between fluid mechanical stresses and development of lesions in the coronary vessels, it is important to analyze the fluid mechanics in actual three-dimensional geometries, incorporating the time-dependent translation and geometric alterations of these vessels [2,3].

Embryonic axis orientation in the mouse and its correlation with blastocyst relationships to the uterus

Development ◽  
1985 ◽  
Vol 89 (1) ◽  
pp. 15-35
Author(s):  
L. J. Smith
Keyword(s):  
Mouse Embryo ◽  
Three Dimensional ◽  
Primitive Streak ◽  
Positional Information ◽  
Uterine Horn ◽  
The Other ◽  
Dimensional System ◽  
Fate Map ◽  
Axis Orientation ◽  
Three Dimensional System

Each of the three primary axes of the primitive streak (6¾ days p.c.) to C-shaped (9½ days) stage mouse embryo has a specific relationship to the uterine horn axes. By a retrograde analysis of younger sectioned embryos it has been possible to construct an axis fate map for the implanting 4¼-day blastocyst and to show how its implantation in one or the other of two specific orientations to the ends and walls of the horn leads to these embryo-horn relationships. The implanting blastocyst axis fate map can be related to an axis fate map of the attached blastocyst (Smith, 1980) since these too are in one or the other of two orientations to the ends and walls of the horn. It is suggested that the asymmetries of the attached and implanting blastocysts that allowed the distinctive attachment and implantation orientations to be recognized, are the initial expressions of a three-dimensional system of positional information that is present in the attached blastocyst.

Metal-mediated multiporphyrin functional assemblies

2009 ◽  
Vol 13 (04n05) ◽  
pp. 481-493 ◽  
Author(s):  
Laura P. Hernández ◽  
Almudena González-Álvarez ◽  
Ana I. Oliva ◽  
Pablo Ballester
Keyword(s):  
Research Group ◽  
Self Assembly ◽  
Three Dimensional ◽  
Great Majority ◽  
Supramolecular Structures ◽  
Assembly Process ◽  
Thermodynamic Characterization ◽  
Closed Loops

During the last ten years, our research group has been applying metal-mediated self-assembly processes to the construction of multiporphyrin functional assemblies. The construction of well-defined and discrete supramolecular structures resulting from self-assembly requires the use of multiple and separated connections operating in one or more closed loops. Consequently, the great majority of the multiporphyrin assemblies that we have prepared are of cyclic nature. We have placed special emphasis not only on the characterization in solution of the formed assemblies but also on the thermodynamic characterization of the assembly process and in the assessment of cooperativity. Finally, we also present examples in which functionality has been derived from the three-dimensional structures of multicomponent assemblies.

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