Abnormal skin development in pupoid foetus (pf/pf) mutant mice

Development ◽  
1985 ◽  
Vol 87 (1) ◽  
pp. 47-64
Author(s):  
Chris Fisher ◽  
Edward J. Kollar
Keyword(s):  
Blood Vessels ◽  
Schwann Cells ◽  
Cell Population ◽  
Epidermal Cell ◽  
Basal Lamina ◽  
Mutant Mice ◽  
Nerve Fibres ◽  
Skin Development ◽  
Cell Layers

At 13 days of development the epidermis of mice homozygous for the pupoid foetus (pf/pf) mutation varies in thickness between one and ten cell layers. By 16 days of development cells from the dermis have invaded the epidermis and may be found throughout the epidermis and on its surface. Among these cells are nerve fibres and Schwann cells as well as other unidentified cells. Antibodies directed against fibronectin bind to these abnormal groups of cells in the mutant epidermis and on its surface. A basal lamina, as determined by ultrastructure and by the immuno-fluorescent localization of laminin, was always found at the interface of the mutant epidermis and the invading cell population. By 19 days of development the mutant epidermis is thickened and is permeated by a network of cells including nerve fibres, Schwann cells, blood vessels, and collagen and fibronectin-secreting cells. A basal lamina always separates these groups of invading cells from the epidermal cell population.

scholarly journals Normal basal laminas are realized on dystrophic Schwann cells in dystrophic in equilibrium shiverer chimera nerves.

1984 ◽  
Vol 99 (5) ◽  
pp. 1831-1837 ◽  
Author(s):  
A C Peterson ◽  
G M Bray
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Cell Population ◽  
Basal Lamina ◽  
Mutant Phenotype ◽  
Normal Product ◽  
Pathogenetic Mechanisms ◽  
Dystrophic Mice

Multiple discontinuities are observed in the basal laminas of Schwann cells in mature dystrophic mice. To explore the pathogenesis of this abnormality we have exploited a dystrophic in equilibrium shiverer mouse chimera preparation in which both the basal lamina phenotype and the genotype of myelin-forming Schwann cells can be determined. If the basal lamina abnormality were to arise from an intrinsic deficiency of the dystrophic Schwann cell itself, only those Schwann cells of dystrophic genotype could express the mutant phenotype, whereas the coexisting population of shiverer Schwann cells should express typically normal basal laminas. No such distinction was observed; rather both dystrophic and shiverer Schwann cells were found to express relatively normal basal laminas and two pathogenetic mechanisms remain theoretical possibilities. The dystrophic Schwann cell population may be intrinsically defective but also may be rescued by obtaining the normal product of the dy locus synthesized by the coexisting shiverer cells. Alternatively, an extra Schwann cell deficiency existing within dystrophic mice may be normalized by shiverer cells and the normal intrinsic potential of both dystrophic and shiverer Schwann cells can then be realized. Regardless of the exact mechanism underlying these findings, some extracellularly mediated influence, emanating in vivo from shiverer cells, is capable of ameliorating the basal lamina deficiency typically expressed by dystrophic Schwann cells.

scholarly journals ULTRASTRUCTURE OF THE CAROTID BODY

1966 ◽  
Vol 30 (3) ◽  
pp. 563-578 ◽  
Author(s):  
T. J. Biscoe ◽  
W. E. Stehbens
Keyword(s):  
Blood Vessels ◽  
Schwann Cells ◽  
Carotid Body ◽  
Nerve Fibers ◽  
Nerve Endings ◽  
Type I ◽  
Type Ii Cells ◽  
Type Ii ◽  
Type I Cells ◽  
I Cells

An electron microscope investigation was made of the carotid body in the cat and the rabbit. In thin-walled blood vessels the endothelium was fenestrated. Larger vessels were surrounded by a layer of smooth muscle fibers. Among the numerous blood vessels lay groups of cells of two types covered by basement membranes. Aggregates of Type I cells were invested by Type II cells, though occasionally cytoplasmic extensions were covered by basement membrane only. Type I cells contained many electron-opaque cored vesicles (350 to 1900 A in diameter) resembling those in endocrine secretory cells. Type II cells covered nerve endings terminating on Type I cells and enclosed nerve fibers in much the same manner as Schwann cells. The nerve endings contained numerous microvesicles (∼500 A in diameter), mitochondria, glycogen granules, and a few electron-opaque cored vesicles. Junctions between nerve endings and Type I cells were associated with regions of increased density in both intercellular spaces and the adjoining cytoplasm. Cilia of the 9 + 0 fibril pattern were observed in Type I and Type II cells and pericytes. Nonmyelinated nerve fibers, often containing microvesicles, mitochondria, and a few electron-opaque cored vesicles (650 to 1000 A in diameter) were present in Schwann cells, many of which were situated close to blood vessels Ganglion cells near the periphery of the gland, fibrocytes, and segments of unidentified cells were also seen. It was concluded that, according to present concepts of the structure of nerve endings, those endings related to Type I cells could be efferent or afferent.

Dermal Dendritic Cell Population and Blood Vessels Are Diminished in the Skin of Systemic Sclerosis Patients

2013 ◽  
Vol 35 (4) ◽  
pp. 438-444 ◽  
Author(s):  
Ana P. de-Sá-Earp ◽  
Adriana P. do Nascimento ◽  
Sueli C. Carneiro ◽  
Luís C. Porto ◽  
Andréa Monte-Alto-Costa
Keyword(s):  
Systemic Sclerosis ◽  
Dendritic Cell ◽  
Blood Vessels ◽  
Cell Population ◽  
Dermal Dendritic Cell ◽  
Dendritic Cell Population

scholarly journals Unravelling crucial biomechanical resilience of myelinated peripheral nerve fibres provided by the Schwann cell basal lamina and PMP22

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Gonzalo Rosso ◽  
Ivan Liashkovich ◽  
Burkhard Gess ◽  
Peter Young ◽  
Alejandra Kun ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Peripheral Nerve ◽  
Basal Lamina ◽  
Nerve Fibres

Co-localization of the myelin-associated glycoprotein and the microfilament components, F-actin and spectrin, in Schwann cells of myelinated nerve fibres

1989 ◽  
Vol 18 (1) ◽  
pp. 47-60 ◽  
Author(s):  
Bruce D. Trapp ◽  
S. Brian Andrews ◽  
Albert Wong ◽  
Maureen O'Connell ◽  
John W. Griffin
Keyword(s):  
Schwann Cells ◽  
Nerve Fibres ◽  
Myelinated Nerve ◽  
Myelin Associated Glycoprotein

scholarly journals Identification and characterization of a resident vascular stem/progenitor cell population in preexisting blood vessels

2011 ◽  
Vol 31 (4) ◽  
pp. 842-855 ◽  
Author(s):  
Hisamichi Naito ◽  
Hiroyasu Kidoya ◽  
Susumu Sakimoto ◽  
Taku Wakabayashi ◽  
Nobuyuki Takakura
Keyword(s):  
Blood Vessels ◽  
Cell Population ◽  
Progenitor Cell ◽  
Progenitor Cell Population ◽  
Identification And Characterization

Trigeminal trophic syndrome: Analysis of the number of peripheral nerve fibres and blood vessels in the lesional skin

2017 ◽  
Vol 59 (1) ◽  
pp. 59-61 ◽  
Author(s):  
Akihiko Uchiyama ◽  
Sei-ichiro Motegi ◽  
Chisako Fujiwara ◽  
Akiko Sekiguchi ◽  
Masahito Yasuda ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Blood Vessels ◽  
Nerve Fibres ◽  
Lesional Skin ◽  
Trigeminal Trophic Syndrome ◽  
Syndrome Analysis
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