Normal product form of two-mode Wigner operator

In the context of normal product, we use the method of the integration within an ordered product (IWOP) of operators to derive three representations of the two-mode Wigner operator: SU (2) symmetric description, SU (1, 1) symmetric description and polar coordinate form. We find that two-mode Wigner operator has multiple potential degrees of freedom. As the physical meaning of the selected integral variable changes, Wigner operator shows different symmetries. In particular, in the case of polar coordinates, we reveal the natural connection between the two-mode Wigner operator and the entangled state representation.

Amalgamation of 3D Printing with Fabrication Robotics

3D printing has always been a matter of curiosity to layman. But for engineers and innovators, 3D printer is viewed as a machine of additive manufacturing domain. It is definitely revolutionary in that area but if we remove such a myopic vision, we can say that a 3D printer is devise giving relative motions in 3 directions. Taking the advantage of this, we can assign multiple roles to 3D printer. In normal product building process, raw materials are converted and processed with subtractive manufacturing processes. Than they are treated with number of fabrication processes for final end product. On this journey, they pass through different layouts and machines. But if we develop a single unit machine where raw product is processed and also fabricated on single bed resulting in end product, than we can bring a paradigm shift in manufacturing technology in prevailing world. Keyword: 1. Additive manufacturing, 2. 3D printing, 3. Digital manufacturing, 4. Rapid prototyping, 5. Industrial engineering.

Consumers Buying Behaviour and Challenges Faced by Consumers During COVID-19 Pandemic Regarding FMCG Products ( During Indian Lockdown)

Pandemics are the imminent health challenges for consumers whereby fear and panic are integral human responses historically. Panic behavior during pandemic is an expected response consumer threatens the ability to cope and destroy the existing balance in life. Consumers develop much-unexplained behavior which differs from region to region, culture to culture. Panic buying / increased buying behavior has been observed during public health emergencies since the ancient period. However, the exact psychological explanation responsible for it has not sought systematically. Therefore, the study is to intend a thrust to identify the possible psychological explanations behind the consumer buying behavior during pandemics. A perception of scarcity is strongly linked with the consumer buying behavior during pandemics, and collecting & saving behaviors increases if the scarcity develops for the immediate necessaries. It also creates a feeling of insecurity which in turn activates another mechanism to collect things. Panic buying also has been linked with perceived feeling of insecurity and instability of certain situations. Furthermore, supply disruption, a condition where normal product supply in supply chain interrupted, has been frequently observed during a disaster or other unwanted calamities. This also led to a feeling of insecurity. The objective of study is to analyze how pandemic affect consumer buying pattern and sentiments.

An Application of Product of Intuitionistic Fuzzy Incidence Graphs in Textile Industry

In this research article, we presented the idea of intuitionistic fuzzy incidence graphs (IFIGs) along with their certain properties. The number of operations including Cartesian product (CP), composition, tensor product, and normal product in an IFIGs are also investigated. The method to compute the degree of IFIGs obtained by CP, composition, tensor product, and the normal product is discussed. Some important theorems to calculate the degree of the vertices of IFIGs acquired by CP, composition, tensor product, and normal product are elaborated. An application of CP and composition of two IFIGs in the textile industry to find the best combinations of departments expressing the highest percentage of progress and the lowest percentage of nonprogress is provided. A comparative analysis of our study with the existing study is discussed. Our study will be beneficial to comprehend and understand the further characteristics of IFIGs in detail. Another advantage of our study is that it will be helpful to find the maximum percentage of progress and minimum percentage of nonprogress in different departments of universities, garment factories, and hospitals.

Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors

Mutations in the isocitrate dehydrogenase-1 and -2 (IDH1/2) genes were first identified in glioma and acute myeloid leukemia (AML), and subsequently found in multiple other tumor types. These neomorphic mutations convert the normal product of enzyme, α-ketoglutarate (αKG), to the oncometabolite 2-hydroxyglutarate (2HG). Our group recently demonstrated that 2HG suppresses the high-fidelity homologous recombination (HR) DNA repair pathway, resulting in a state referred to as ‘BRCAness’, which confers exquisite sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors. In this study, we sought to elucidate sensitivity of IDH1/2-mutant cells to DNA damage response (DDR) inhibitors and, whether combination therapies could enhance described synthetic lethal interactions. Here, we report that ATR (ataxia telangiectasia and Rad3-related protein kinase) inhibitors are active against IDH1/2-mutant cells, and that this activity is further potentiated in combination with PARP inhibitors. We demonstrate this interaction across multiple cell line models with engineered and endogenous IDH1/2 mutations, with robust anti-tumor activity in vitro and in vivo. Mechanistically, we found ATR and PARP inhibitor treatment induces premature mitotic entry, which is significantly elevated in the setting of IDH1/2-mutations. These data highlight the potential efficacy of targeting HR defects in IDH1/2-mutant cancers and support the development of this combination in future clinical trials.

Nonclassicality revival of photon-added displaced thermal states in the amplitude decay channel

In this paper, the decoherence features of the photon-added displaced thermal state (PADTS) in the amplitude decay channel were studied by analytically and numerically investigating the time evolution of the Wigner function. The normal product representation of density for the PADTS is presented. The results indicate that the nonclassicality of PADTS can revive after disappearing with time. This kind of revival can maintain for a period of time and inevitably disappear eventually. However, we find that the operation of adding photons has the effect of reducing the decoherence rate of PADTS in the amplitude decay channel, although it also can decrease the PADTS’s nonclassicality markedly.

The Landscape of the Anti-Kinase Activity of the IDH1 Inhibitors

Isocitrate dehydrogenases constitute a class of enzymes that are crucial for cellular metabolism. The overexpression or mutation of isocitrate dehydrogenases are often found in leukemias, glioblastomas, lung cancers, and ductal pancreatic cancer among others. Mutation R132H, which changes the functionality of an enzyme to produce mutagenic 2-hydroxyglutarate instead of a normal product, is particularly important in this field. A series of inhibitors were described for these enzymes of which ivosidenib was the first to be approved for treating leukemia and bile duct cancers in 2018. Here, we investigated the polypharmacological landscape of the activity for known sulfamoyl derivatives that are inhibitors, which are selective towards IDH1 R132H. These compounds appeared to be effective inhibitors of several non-receptor kinases at a similar level as imatinib and axitinib. The antiproliferative activity of these compounds against a panel of cancer cells was tested and is explained based on the relative expression levels of the investigated proteins. The multitargeted activity of these compounds makes them valuable agents against a wide range of cancers, regardless of the status of IDH1.

Belief in Science? On the Neuroscience of Religion

This afterword demonstrates how the return of religion to public life has had an impact on science. Faith itself has become an object of physiological study, with researchers deploying brain scans to identify a “God spot,” the supposed seat of a wired-in human spirituality. The afterword then considers the growing field of “neurotheology.” Rather than asking whether God exists and contemplating His divine nature, neurotheology seeks to ascertain whether religious experience is a normal product of brain function or the result of neural pathology. The reality has, however, not lived up to the hype. Far from overcoming theological stalemate, neurotheology has merely refought old battles on new terrain. Both believers and skeptics have been able to draw on neuroscientific results to shore up their positions, and debates have returned as vigorous and apparently intractable as before. In fact, rather than being a refuge from polemic, neurotheology provides evidence that debate over theological questions might not admit final resolution. Whatever its claims, neurotheology's most important lesson might be that people are better advised to respect religious differences than to try to overcome them.