scholarly journals Bicuspid aortic valve formation: Nos3 mutation leads to abnormal lineage patterning of neural crest cells and the second heart field

2018 ◽  
Vol 11 (10) ◽  
pp. dmm034637 ◽  
Author(s):  
Joshua C. Peterson ◽  
Mary Chughtai ◽  
Lambertus J. Wisse ◽  
Adriana C. Gittenberger-de Groot ◽  
Qingping Feng ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Neural Crest ◽  
Bicuspid Aortic Valve ◽  
Neural Crest Cells ◽  
Second Heart Field ◽  
Heart Field ◽  
Valve Formation

scholarly journals New Concepts in the Development and Malformation of the Arterial Valves

2020 ◽  
Vol 7 (4) ◽  
pp. 38
Author(s):  
Deborah J. Henderson ◽  
Lorraine Eley ◽  
Bill Chaudhry
Keyword(s):  
Aortic Valve ◽  
Neural Crest ◽  
Bicuspid Aortic Valve ◽  
Endocardial Cushions ◽  
Developmental Models ◽  
Second Heart Field ◽  
Valve Development ◽  
Current State ◽  
New Concepts ◽  
Heart Field

Although in many ways the arterial and atrioventricular valves are similar, both being derived for the most part from endocardial cushions, we now know that the arterial valves and their surrounding structures are uniquely dependent on progenitors from both the second heart field (SHF) and neural crest cells (NCC). Here, we will review aspects of arterial valve development, highlighting how our appreciation of NCC and the discovery of the SHF have altered our developmental models. We will highlight areas of research that have been particularly instructive for understanding how the leaflets form and remodel, as well as those with limited or conflicting results. With this background, we will explore how this developmental knowledge can help us to understand human valve malformations, particularly those of the bicuspid aortic valve (BAV). Controversies and the current state of valve genomics will be indicated.

scholarly journals Krox20 defines a subpopulation of cardiac neural crest cells contributing to arterial valves and bicuspid aortic valve

Development ◽  
2017 ◽  
Vol 145 (1) ◽  
pp. dev151944 ◽  
Author(s):  
Gaëlle Odelin ◽  
Emilie Faure ◽  
Fanny Coulpier ◽  
Maria Di Bonito ◽  
Fanny Bajolle ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Neural Crest ◽  
Bicuspid Aortic Valve ◽  
Neural Crest Cells ◽  
Cardiac Neural Crest

scholarly journals Pulmonary ductal coarctation and left pulmonary artery interruption; pathology and role of neural crest and second heart field during development

2020 ◽  
Author(s):  
Adriana C. Gittenberger-de Groot ◽  
Joshua C. Peterson ◽  
Lambertus J. Wisse ◽  
Arno A.W. Roest ◽  
Robert E. Poelmann ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Neural Crest ◽  
Ductus Arteriosus ◽  
Pulmonary Stenosis ◽  
Neural Crest Cells ◽  
Left Pulmonary Artery ◽  
Pulmonary Trunk ◽  
Human Embryos ◽  
Second Heart Field ◽  
Heart Field

AbstractObjectivesIn congenital heart malformations with pulmonary stenosis to atresia an abnormal lateral ductus arteriosus to left pulmonary artery connection can lead to a localised narrowing (pulmonary ductal coarctation) or even interruption We investigated embryonic remodelling and pathogenesis of this area.Material and methods. Normal development was studied in WntCre reporter mice (E10.0-12.5) for neural crest cells and Nkx2.5 immunostaining for second heart field cells. Data were compared to stage matched human embryos and a VEGF120/120 mutant mouse strain developing pulmonary atresia.ResultsNormal mouse and human embryos showed that the mid-pharyngeal endothelial plexus, connected side-ways to the 6th pharyngeal arch artery. The ventral segment formed the proximal pulmonary artery. The dorsal segment (future DA) was solely surrounded by neural crest cells. The ventral segment had a dual outer lining with neural crest and second heart field cells, while the distal pulmonary artery was covered by none of these cells. The asymmetric contribution of second heart field to the future pulmonary trunk on the left side of the aortic sac (so-called pulmonary push) was evident. The ventral segment became incorporated into the pulmonary trunk leading to a separate connection of the left and right pulmonary arteries. The VEGF120/120 embryos showed a stunted pulmonary push and a variety of vascular anomalies.SummarySide-way connection of the DA to the left pulmonary artery is a congenital anomaly. The primary problem is a stunted development of the pulmonary push leading to pulmonary stenosis/atresia and a subsequent lack of proper incorporation of the ventral segment into the aortic sac. Clinically, the aberrant smooth muscle tissue of the ductus arteriosus should be addressed to prohibit development of severe pulmonary ductal coarctation or even interruption of the left pulmonary artery.

scholarly journals Cardiac, mandibular and thymic phenotypical association indicates that cranial neural crest underlies bicuspid aortic valve formation in hamsters

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0183556 ◽  
Author(s):  
Jessica Martínez-Vargas ◽  
Jacint Ventura ◽  
Ángela Machuca ◽  
Francesc Muñoz-Muñoz ◽  
María Carmen Fernández ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Neural Crest ◽  
Bicuspid Aortic Valve ◽  
Cranial Neural Crest ◽  
Valve Formation

scholarly journals Semaphorin3D regulates invasion of cardiac neural crest cells into the primary heart field

2006 ◽  
Vol 298 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Mariko Sato ◽  
Huai-Jen Tsai ◽  
H. Joseph Yost
Keyword(s):  
Neural Crest ◽  
Neural Crest Cells ◽  
Cardiac Neural Crest ◽  
Heart Field

scholarly journals Islet1 Derivatives in the Heart Are of Both Neural Crest and Second Heart Field Origin

2012 ◽  
Vol 110 (7) ◽  
pp. 922-926 ◽  
Author(s):  
Kurt A. Engleka ◽  
Lauren J. Manderfield ◽  
Rachael D. Brust ◽  
Li Li ◽  
Ashley Cohen ◽  
...  
Keyword(s):  
Neural Crest ◽  
Second Heart Field ◽  
Heart Field

scholarly journals A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Lorriane Eley ◽  
Ahlam MS Alqahtani ◽  
Donal MacGrogan ◽  
Rachel V Richardson ◽  
Lindsay Murphy ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Congenital Malformations ◽  
Heart Valves ◽  
Atrioventricular Valve ◽  
Aortic Valves ◽  
Mesenchymal Transition ◽  
Valve Interstitial Cells ◽  
Valve Formation ◽  
Dependent Mechanism

Abnormalities of the arterial valve leaflets, predominantly bicuspid aortic valve, are the commonest congenital malformations. Although many studies have investigated the development of the arterial valves, it has been assumed that, as with the atrioventricular valves, endocardial to mesenchymal transition (EndMT) is the predominant mechanism. We show that arterial is distinctly different from atrioventricular valve formation. Whilst the four septal valve leaflets are dominated by NCC and EndMT-derived cells, the intercalated leaflets differentiate directly from Tnnt2-Cre+/Isl1+ progenitors in the outflow wall, via a Notch-Jag dependent mechanism. Further, when this novel group of progenitors are disrupted, development of the intercalated leaflets is disrupted, resulting in leaflet dysplasia and bicuspid valves without raphe, most commonly affecting the aortic valve. This study thus overturns the dogma that heart valves are formed principally by EndMT, identifies a new source of valve interstitial cells, and provides a novel mechanism for causation of bicuspid aortic valves without raphe.

scholarly journals Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Kazuki Kodo ◽  
Shinsuke Shibata ◽  
Sachiko Miyagawa-Tomita ◽  
Sang-Ging Ong ◽  
Hiroshi Takahashi ◽  
...  
Keyword(s):  
Neural Crest ◽  
Outflow Tract ◽  
Cardiac Neural Crest ◽  
Second Heart Field ◽  
Heart Field
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