scholarly journals Nuclear structure: determination of the fate of the nuclear envelope in Drosophila during mitosis using monoclonal antibodies

1983 ◽  
Vol 64 (1) ◽  
pp. 331-349 ◽  
Author(s):  
J.P. Fuchs ◽  
H. Giloh ◽  
C.H. Kuo ◽  
H. Saumweber ◽  
J. Sedat
Keyword(s):  
Nuclear Envelope ◽  
Nuclear Structure ◽  
Structure And Function ◽  
Nuclear Proteins ◽  
Longitudinal Gradient ◽  
Indirect Immunofluorescence Staining ◽  
Nuclear Events ◽  
And Function ◽  
Drosophila Embryos

Libraries of monoclonal antibody against nuclear proteins of Drosophila melanogaster have been established recently to investigate nuclear structure and function. Some of the antibodies have been characterized as being directed against the nuclear envelope. Further studies detailed in this paper describe the fate of the nuclear envelope during mitosis. Indirect immunofluorescence staining of whole developing Drosophila embryos has been used as a system in which nuclear events can be studied both synchronously and in a longitudinal gradient of mitotic structures. The results show a pattern of breakdown and reconstruction of the nuclear envelope in which the antigen is always present in particulate structures. In addition, the processes of antigen rearrangement are shown to be spatially determined throughout mitosis.

scholarly journals Nuclear envelope mechanobiology: linking the nuclear structure and function

Nucleus ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 90-114
Author(s):  
Matthew Goelzer ◽  
Julianna Goelzer ◽  
Matthew L. Ferguson ◽  
Corey P. Neu ◽  
Gunes Uzer
Keyword(s):  
Nuclear Envelope ◽  
Nuclear Structure ◽  
Structure And Function ◽  
And Function

Assessment of the impact of nanoparticles on the activity of biomimetic membrane

2021 ◽  
Vol XXXVII (1) ◽  
pp. 89-100
Author(s):  
Dorota Kondej
Keyword(s):  
Occupational Safety ◽  
Biological Membranes ◽  
Structure And Function ◽  
Lipid Monolayer ◽  
Biomimetic Membranes ◽  
Safety And Health ◽  
Biomimetic Membrane ◽  
And Function ◽  
The Impact

This paper presents basic information on a structure and function of biological membranes. Types of biomimetic membranes modelling properties of biological membranes were introduced. The method of testing surface properties of a lipid monolayer, which is the basic type of biomimetic membranes, was described. The presented method makes it possible to evaluate the effect of nanoparticles on the surface activity of biomimetic membranes based on the determination of the surface index MA. This article discusses the problems of occupational safety and health, which are covered by health sciences and environmental engineering.

scholarly journals DETERMINATION OF THE QUANTITY OF SECRETING TISSUE IN THE LIVING KIDNEY

1918 ◽  
Vol 28 (3) ◽  
pp. 359-376 ◽  
Author(s):  
C. K. Watanabe ◽  
Jean Oliver ◽  
Thomas Addis
Keyword(s):  
Structure And Function ◽  
Urea Content ◽  
And Function

1. Under the strain induced by the administration of urea, it is possible to demonstrate the relation between the degree of anatomical damage in the kidney and the degree of defect in the urea-excreting capacity induced by uranium. 2. The closest correlation between structure and function was obtained when the ratio between the urea content of the urine and of the blood was used as the measure of function.

scholarly journals 60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective

2016 ◽  
Vol 56 (4) ◽  
pp. T13-T25 ◽  
Author(s):  
D G Smyth
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Amino Acid Analysis ◽  
Structure And Function ◽  
Biologically Active ◽  
Molecular Endocrinology ◽  
And Function ◽  
The Brain ◽  
Quantitative Amino Acid Analysis

Many important fields of research had a humble origin. In the distant past, A J P Martin’s discovery that amino acids could be separated by paper chromatography and Moore and Stein’s use of columns for quantitative amino acid analysis provided the first steps towards the determination of structure in complex biologically active molecules. They opened the door to reveal the essential relationship that exists between structure and function. In molecular endocrinology, for example, striking advances have been made by chemists with their expertise in the identification of structure working with biologists who contributed valuable knowledge and experience. Advantage was gained from the convergence of different background, and it is notable that the whole is greater than the sum. In the determination of structure, it may be recalled that four of the world’s great pioneers (Archibald Martin, Rodney Porter, Fred Sanger and Vincent du Vigneaud) were acknowledged for their fundamental contributions when individually they were awarded the Nobel Prize. They foresaw that the identification of structure would prove of outstanding importance in the future. Indeed, study of the structures of β-endorphin and enkephalin and the different forms of opiate activity they engender has led to a transformation in our understanding of chemical transmission in the brain.

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