Liver Blood Flow: Non-Invasive Estimation Using a Gamma Camera

1992 ◽  
Vol 206 (2) ◽  
pp. 99-103 ◽  
Author(s):  
W B Tindale ◽  
D C Barber ◽  
H L Smart ◽  
D R Triger
Keyword(s):  
Blood Flow ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Computer Analysis ◽  
Gamma Camera ◽  
Liver Blood Flow ◽  
Time Activity ◽  
Non Invasive ◽  
First Pass

A non-invasive radioisotope technique for the measurement of total liver blood flow (TBF) is described. The method requires the use of two intravenously administered tracers, 99mTc (technetium 99m) human serum albumin (HSA) and 99mTc colloid. Computer analysis of first-pass time activity curves for HSA for liver and lung tissues yields values for the arterial and portal contributions to liver blood flow, from which TBF can be determined. These values are then corrected for attenuation using the images of the colloid distribution. The use of the method is illustrated in 17 subjects. Assumptions, limitations and possible applications of the technique are discussed.

scholarly journals THE ESTIMATION OF HEPATIC BLOOD FLOW AND INTRAHEPATIC SHUNTED BLOOD FLOW BY COLLOIDAL HEAT-DENATURED HUMAN SERUM ALBUMIN LABELED WITH I131

1961 ◽  
Vol 40 (7) ◽  
pp. 1346-1354 ◽  
Author(s):  
Stanley Shaldon ◽  
Livio Chiandussi ◽  
Luis Guevara ◽  
John Caesar ◽  
Sheila Sherlock
Keyword(s):  
Blood Flow ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Hepatic Blood Flow

Lung Scanning with the Gamma Camera, Using Complexes of 99mTc-Sulphur Colloid and Macroaggregated Human Serum Albumin

1971 ◽  
Vol 10 (02) ◽  
pp. 129-134
Author(s):  
Clas Nordman ◽  
Theodor Weber
Keyword(s):  
Pulmonary Embolism ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Gamma Camera ◽  
Lateral View ◽  
Test Substance ◽  
Suspected Pulmonary Embolism ◽  
Lung Scanning ◽  
Anterior Posterior

SummaryThe results of lung scanning in suspected pulmonary embolism, using the gamma camera and complexes of 99mTc-sulphur colloid and macroaggregated human serum albumin are presented. In a series of 52 patients excellent scanning images were obtained in each case, without any adverse side effects. The preparation of the test substance takes about 20 minutes and can be performed routinely by a laboratory technician. The use of a gamma camera in connection with this test substance allows anterior, posterior and lateral view scanning to be performed within 15 minutes, with minimal strain on the patients. Multipleview scanning is shown to be necessary in screening for pulmonary embolism.

scholarly journals Determination of Non-Invasive Biomarkers for the Assessment of Fibrosis, Steatosis and Hepatic Iron Overload by MR Image Analysis. A Pilot Study

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1178
Author(s):  
Alba Meneses ◽  
José Manuel Santabárbara ◽  
Juan Antonio Romero ◽  
Roberto Aliaga ◽  
Alicia María Maceira ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Iron Overload ◽  
Serum Albumin ◽  
Human Serum ◽  
Relaxation Times ◽  
Hepatic Iron ◽  
Mr Image ◽  
Non Invasive ◽  
Hepatic Iron Overload ◽  
Paravertebral Muscles

The reference diagnostic test of fibrosis, steatosis, and hepatic iron overload is liver biopsy, a clear invasive procedure. The main objective of this work was to propose HSA, or human serum albumin, as a biomarker for the assessment of fibrosis and to study non-invasive biomarkers for the assessment of steatosis and hepatic iron overload by means of an MR image acquisition protocol. It was performed on a set of eight subjects to determine fibrosis, steatosis, and hepatic iron overload with four different MRI sequences. We calibrated longitudinal relaxation times (T1 [ms]) with seven human serum albumin (HSA [%]) phantoms, and we studied the relationship between them as this protein is synthesized by the liver, and its concentration decreases in advanced fibrosis. Steatosis was calculated by means of the fat fraction (FF [%]) between fat and water liver signals in “fat-only images” (the subtraction of in-phase [IP] images and out-of-phase [OOP] images) and in “water-only images” (the addition of IP and OOP images). Liver iron concentration (LIC [µmol/g]) was obtained by the transverse relaxation time (T2* [ms]) using Gandon’s method with multiple echo times (TE) in T2-weighted IP and OOP images. The preliminary results showed that there is an inverse relationship (r = −0.9662) between the T1 relaxation times (ms) and HSA concentrations (%). Steatosis was determined with FF > 6.4% and when the liver signal was greater than the paravertebral muscles signal, and thus, the liver appeared hyperintense in fat-only images. Hepatic iron overload was detected with LIC > 36 µmol/g, and in these cases, the liver signal was smaller than the paravertebral muscles signal, and thus, the liver behaved as hypointense in IP images.

Measurement of the pulmonary vascular granulocyte pool

1995 ◽  
Vol 78 (4) ◽  
pp. 1388-1395 ◽  
Author(s):  
W. Y. Ussov ◽  
A. M. Peters ◽  
D. M. Glass ◽  
R. D. Gunasekera ◽  
J. M. Hughes
Keyword(s):  
Human Serum Albumin ◽  
Pulmonary Artery ◽  
Right Ventricle ◽  
Serum Albumin ◽  
Human Serum ◽  
Superior Vena Cava ◽  
Count Rate ◽  
Superior Vena ◽  
Vena Cava ◽  
First Pass

We have developed a technique for measuring the pulmonary granulocyte pool (PGP) as a fraction of the whole body total blood granulocyte pool (TBGP). The technique “captures” a dose of 99mTc-labeled granulocytes in a region of interest (ROI) over the lung during first pass by integrating an input time-activity curve from an ROI over the pulmonary artery, superior vena cava, or right ventricle. The ratio of the estimated first-pass count rate and the count rate in the same lung ROI after equilibration of the cells between the circulating and pulmonary pools (15–30 min) represents the PGP/TBGP. The technique was validated in eight subjects by using 99mTc-labeled macroaggregated human serum albumin. With corrections for background and injected doses, the ratios of first-pass granulocyte-to-macroaggregated human serum albumin count rates given by the three input ROIs were close to unity [superior vena cava 0.98 +/- 0.079 (SD), right ventricle 1.01 +/- 0.070, and pulmonary artery 0.97 +/- 0.073]. Significant increases in PGP/TBGP were demonstrated in systemic inflammation. Thus, in patients with inflammatory bowel disease, it was 0.22 +/- 0.07 (n = 7) compared with 0.08 +/- 0.01 (n = 5) in control subjects. It was also elevated in patients with systemic vasculitis (0.34 +/- 0.07; n = 5), in transplant recipients (0.33 +/- 0.08; n = 5), and in patients with osteomyelitis (0.15 +/- 0.06; n = 4). We conclude that this is a valid technique for quantifying the PGP that is expanded in several conditions associated with systemic inflammation.

VALIDITY OF MEASURING REGIONAL PULMONARY ARTERIAL BLOOD FLOW WITH MACROAGGREGATES OF HUMAN SERUM ALBUMIN

1966 ◽  
Vol 96 (3) ◽  
pp. 664-676 ◽  
Author(s):  
DONALD E. TOW ◽  
HENRY N. WAGNER ◽  
VINCENT LOPEZ-MAJANO ◽  
EDWARD M. SMITH ◽  
TOHRU MIGITA
Keyword(s):  
Blood Flow ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Arterial Blood Flow ◽  
Arterial Blood ◽  
Pulmonary Arterial

scholarly journals Alteration of pulmonary blood flow in tetralogy of Fallot: pre- and postoperative study with macroaggregates of 99mTc-labeled human serum albumin.

1992 ◽  
Vol 56 (10) ◽  
pp. 992-997 ◽  
Author(s):  
KAZUHIRO HASHIMOTO ◽  
YUZURU NAKAMURA ◽  
MICHIHIKO MATSUI ◽  
HIROMI KUROSAWA ◽  
TATSUTA ARAI
Keyword(s):  
Blood Flow ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tetralogy Of Fallot ◽  
Pulmonary Blood Flow ◽  
Postoperative Study

II. Lokalisation der Placenta mit 113Inm- Human-Serum-Albumin

1969 ◽  
Vol 08 (01) ◽  
pp. 15-21 ◽  
Author(s):  
K. E. Scheer ◽  
J. Heep ◽  
W. Maier-Borst ◽  
W. J. Lorenz ◽  
H. Sinn ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Vena Cava ◽  
Placenta Praevia ◽  
Wird Eine

ZusammenfassungNach tierexperimentellen Voruntersuchungen wurde die Placentographie mit trägerfreiem 113Inm -HSA als klinische Methode eingeführt. Vor Amniocentesen und bei Verdacht auf Placenta praevia werden Placentographien geschrieben. Den Schwangeren wird eine Aktivität von 500 μCi in die Cubitalvene injiziert. Die der Aktivität entsprechende Indiummenge ist kleiner als 0,1 ng. Die fetale Strahlenbelastung liegt unter lOmrad. Bei Anwendung von 113Inm-HSA entfällt eine Blockade der mütterlichen und fetalen Schilddrüsen. Die genaue Abgrenzung einer Placenta praevia wird nicht durch eine Blasenaktivität beeinträchtigt.Es wurden bisher 19 Placentalokalisationen durchgeführt. In allen Fällen konnte der Placentasitz eindeutig festgestellt werden. Bedingt durch die lange Liegezeit beim Aufnehmen eines Szintigramms kam es in zwei Fällen zu einem Vena-Cava-Kompressions-Syndrom. Zur Verhinderung dieser klinischen Zwischenfälle werden inzwischen Placentographien mit der Anger-Kamera aufgenommen. Mit Hilfe des divergierenden Kollimators konnte der gesamte Abdominalbereich erfaßt werden. Die Aufnahmezeit konnte auf 7 — 10 Minuten verkürzt werden. Die intravenöse injizierte Aktivität betrug bei dieser Methode ebenfalls 500 μCi. Der diagnostische Aussagewert der Kamerabilder ist szintigraphischen Aufnahmen gleichwertig.

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