Prognostic Relevance of Occult Metastases Detected by Cytokeratin 20 and Mucin 2 mRNA Levels in Sentinel Lymph Nodes from Colon Cancer Patients

2012 ◽  
Vol 19 (12) ◽  
pp. 3719-3726 ◽  
Author(s):  
Oddmund Nordgård ◽  
Satu Oltedal ◽  
Ole Gunnar Aasprong ◽  
Jon Arne Søreide ◽  
Kjetil Søreide ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Sentinel Lymph Nodes ◽  
Mrna Levels ◽  
Cytokeratin 20 ◽  
Occult Metastases ◽  
Prognostic Relevance ◽  
Mucin 2

The potential of cytokeratin 20 and mucin 2 mRNA as metastasis markers in regional lymph nodes of colon cancer patients investigated by quantitative RT-PCR

2009 ◽  
Vol 24 (3) ◽  
pp. 261-268 ◽  
Author(s):  
Oddmund Nordgård ◽  
Satu Oltedal ◽  
Hartwig Kørner ◽  
Ole Gunnar Aasprong ◽  
Kjersti Tjensvoll ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Cytokeratin 20 ◽  
Rt Pcr ◽  
Regional Lymph Nodes ◽  
Mucin 2

scholarly journals Prognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Guro E. Lind ◽  
Marianne Guriby ◽  
Terje Ahlquist ◽  
Israr Hussain ◽  
Marine Jeanmougin ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Sentinel Lymph Nodes ◽  
Biomarker Panel ◽  
Prognostic Relevance ◽  
Epigenetic Biomarker

Detection of Occult Metastases in Sentinel Lymph Nodes From Colon Cancer Patients by K-ras Mutation Peptide Nucleic Acid Clamp PCR

2010 ◽  
Vol 251 (6) ◽  
pp. 1087-1091 ◽  
Author(s):  
Satu Oltedal ◽  
Bjørnar Gilje ◽  
Hartwig Kørner ◽  
Ole Gunnar Aasprong ◽  
Kjersti Tjensvoll ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Nucleic Acid ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Peptide Nucleic Acid ◽  
Sentinel Lymph Nodes ◽  
Ras Mutation ◽  
Occult Metastases

The Diagnostic Value of One-Step Nucleic acid Amplification (OSNA) for Sentinel Lymph Nodes in Colon Cancer Patients

2014 ◽  
Vol 21 (12) ◽  
pp. 3924-3930 ◽  
Author(s):  
F. J. Vogelaar ◽  
M. S. Reimers ◽  
R. L. A. van der Linden ◽  
J. C. van der Linden ◽  
V. T. H. B. M. Smit ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Nucleic Acid ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Diagnostic Value ◽  
Sentinel Lymph Nodes ◽  
Nucleic Acid Amplification ◽  
One Step

scholarly journals The Chemokine CXCL16 Is a New Biomarker for Lymph Node Analysis of Colon Cancer Outcome

2019 ◽  
Vol 20 (22) ◽  
pp. 5793 ◽  
Author(s):  
Manar AbdelMageed ◽  
Haytham Ali ◽  
Lina Olsson ◽  
Gudrun Lindmark ◽  
Marie-Louise Hammarström ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Protein Expression ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Mrna Levels ◽  
Colon Tissue ◽  
Regional Lymph Nodes ◽  
Primary Tumors ◽  
Kaplan Meier ◽  
Cancer Outcome

Chemokines are important in the development and progression of tumors. We investigated the expression of CXCL14 and CXCL16 in colon cancer. Expression of mRNA was assessed in primary tumors and lymph nodes and CXCL16 mRNA levels were correlated to patient’s survival. Protein expression was investigated by two-color immunofluorescence and immunomorphometry. CXCL14 and CXCL16 mRNA levels and protein expression were significantly higher in colon cancer primary tumors compared to apparently normal colon tissue. Positive cells were tumor cells, as revealed by anti-CEA and anti-EpCAM staining. CXCL16, but not CXCL14, mRNA levels were significantly higher in hematoxylin and eosin positive (H&E(+)) compared to H&E(−) colon cancer lymph nodes or control nodes (P < 0.0001). CXCL16 mRNA was expressed in 5/5 colon cancer cell lines while CXCL14 was expressed significantly in only one. Kaplan-Meier analysis revealed that colon cancer patients with lymph nodes expressing high or very high levels (7.2 and 11.4 copies/18S rRNA unit, respectively) of CXCL16 mRNA had a decreased mean survival time of 30 and 46 months at the 12-year follow-up (P = 0.04, P = 0.005, respectively). In conclusion, high expression of CXCL16 mRNA in regional lymph nodes of colon cancer patients is a sign of a poor prognosis.

Clinical significance of occult metastases in sentinel lymph nodes in breast cancer patients

2012 ◽  
Vol 73 (12) ◽  
pp. 3021-3025
Author(s):  
Takeshi NAGASHIMA ◽  
Masahiro SAKAKIBARA ◽  
Hiroshi FUJIMOTO ◽  
Tiberiu-Hiroshi SUZUKI ◽  
Kaoru FUJISAKI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Clinical Significance ◽  
Sentinel Lymph Nodes ◽  
Breast Cancer Patients ◽  
Occult Metastases

Carbon Dye Staining of Sentinel Lymph Nodes Facilitates Microstaging of Colon Cancer Patients

2006 ◽  
Vol 30 (3) ◽  
pp. 453-456 ◽  
Author(s):  
Carsten T. Viehl ◽  
Ulrich Guller ◽  
Christian T. Hamel ◽  
Hans-Martin Riehle ◽  
Christian Plaass ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Sentinel Lymph Nodes ◽  
Dye Staining
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