Serum Concentrations of Δ5-3β-Hydroxysteroids in Type 2 Diabetes Mellitus

Aim. To estimate the relationships between the serum concentrations of acute-phase proteins (APPs) and adipocytokines, body composition (BC), and blood glucose (BG) fluctuations in women with type 2 diabetes mellitus (T2DM). Subjects and methods. A total of 165 women with T2DM and 22 with a normal body mass index (BMI) at the age of 40 to 70 years were examined. The concentrations of high-sensitivity C-reactive protein (hs-CRP) and acid α1-glycoprotein (α1-AGP) were determined by ELISA. The levels of interleukins 6, 8, and 18 (IL-6, IL-8, IL-18), tumor necrosis factor-α (TNF-α), and plasminogen activator inhibitor type 1 (PAI-1) were measured by a multiplex analysis. Dual energy X-ray absorptiometry was used to estimate BC parameters. BG fluctuations were estimated via continuous glucose monitoring. Results. The levels of hs-CRP, α1-AGP, IL-6, IL-8, IL-18, TNF-α, and PAI-1 were significantly higher in the obese women with T2DM than those in the control group. In the diabetic normal weight women, only hs-CRP, α1-AGP, and IL-8 concentrations exceeded those in the controls. The level of hs-CRP (other than α1-AGP) correlated positively with BMI, the mass of adipose tissue, body trunk (android), and gynoid fats. A multivariate regression analysis showed that adipose tissue mass and trunk fat proportion were independent predictors of hs-CRP levels. The concentrations of IL-6, IL-8, IL-18, PAI-1, and TNF-α correlated positively with waist-to-hip ratio, but demonstrated no associations with BMI and BC. Only the serum α1-AGP level showed a positive association with mean BG and its variability parameters. Conclusion. In the women with T2DM, the serum concentrations of APPs and adipocytokines correlate differently with the mass of adipose tissue, its distribution, and BG fluctuations. The findings indicate the multifactorial genesis of chronic inflammation in these patients.

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Relationship between the Serum Concentrations of C-reactive Protein and Parameters of Adiposity and Insulin Resistance in Patients with Type 2 Diabetes Mellitus

Endocrine Journal ◽

10.1507/endocrj.k05-133 ◽

2006 ◽

Vol 53 (3) ◽

pp. 345-356 ◽

Cited By ~ 20

Author(s):

Tomoyuki IWASAKI ◽

Atsushi NAKAJIMA ◽

Masato YONEDA ◽

Yasuo TERAUCHI

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Serum Concentrations ◽

C Reactive Protein ◽

Reactive Protein

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Fibroblast growth factor 21 serum concentrations in patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (DM2).

Atherosclerosis ◽

10.1016/j.atherosclerosis.2018.06.449 ◽

2018 ◽

Vol 275 ◽

pp. e151

Author(s):

M. Walus-miarka ◽

B. Idzior-Walus ◽

M. Kapusta ◽

A. Trojak ◽

P. Miarka ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Fatty Liver Disease ◽

Fibroblast Growth Factor 21 ◽

Fibroblast Growth ◽

Serum Concentrations ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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The effect of two concurrent exercise modalities on serum concentrations of FGF21, irisin, follistatin, and myostatin in men with type 2 diabetes mellitus

Archives of Physiology and Biochemistry ◽

10.1080/13813455.2020.1829649 ◽

2020 ◽

pp. 1-10

Author(s):

Morteza Motahari Rad ◽

Nahid Bijeh ◽

Seyyed Reza Attarzadeh Hosseini ◽

Aliakbar Raouf Saeb

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Serum Concentrations ◽

Concurrent Exercise

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Exposure to persistent organochlorine pollutants and type 2 diabetes mellitus

Human & Experimental Toxicology ◽

10.1177/0960327107076886 ◽

2007 ◽

Vol 26 (5) ◽

pp. 447-452 ◽

Cited By ~ 85

Author(s):

Anna Rignell-Hydbom ◽

Lars Rylander ◽

Lars Hagmar

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Odds Ratio ◽

Epidemiological Studies ◽

Serum Concentrations ◽

Serum Samples ◽

Persistent Organochlorine ◽

Organochlorine Pollutants

Persistent organochlorine pollutants (POPs), such aspolychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), dichloro diphenyl trichloroethane (DDT) and its major metabolite 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p' -DDE) have been associated with type 2 diabetes mellitus (T2DM) in recent epidemiological studies. We have analysed 2,2',4,4',5,5' -hexachlorobiphenyl (CB-153) and p,p'-DDE in 544 serum-samples from Swedish women with a median age of 50 years. The participants were asked if they had diabetesand if so, what type of diabetes, years since diagnosis and what kind of treatment they had. Associations between exposure and T2DM were analysed by logistic regression. Moreover, trends of T2DM prevalence were tested with Jonckheere-Terpstra' test. Sixteen of the 544 women (3%) had diabetes, of which15 were classified as T2DM. There was a significant associationwith T2DM for both CB-153 (an increase of 100ng/glipid corresponded to an odds ratio [OR] of 1. 6, 95% confidenceinterval [CI] 1. 0, 2. 7) and p,p9-DDE (OR 1. 3, 95%CI 1. 1, 1. 6). In addition, significant positive trends betweenquartiles of CB-153 and T2DM (P 5 0. 004) and p,p9-DDEand T2DM (P 5 0. 002) were observed. The study showsan association between POP serum concentrations andan increased prevalence of T2DM. Human & Experimental Toxicology (2007) 26, 447—451

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Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial

Journal of Internal Medicine ◽

10.1046/j.1365-2796.2003.01213.x ◽

2003 ◽

Vol 254 (5) ◽

pp. 455-463 ◽

Cited By ~ 124

Author(s):

M. G. Wulffele ◽

A. Kooy ◽

P. Lehert ◽

D. Bets ◽

J. C. Ogterop ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Controlled Trial ◽

Term Treatment ◽

Serum Concentrations ◽

Short Term ◽

Short Term Treatment ◽

Folate And Vitamin B12

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Serum Concentrations of Fibroblast Growth Factor 19 in Patients With Obesity and Type 2 Diabetes Mellitus: the Influence of Acute Hyperinsulinemia, Very-Low Calorie Diet and PPAR-α Agonist Treatment

Physiological Research ◽

10.33549/physiolres.932099 ◽

2011 ◽

pp. 627-636 ◽

Cited By ~ 34

Author(s):

M. MRÁZ ◽

Z. LACINOVÁ ◽

P. KAVÁLKOVÁ ◽

D. HALUZÍKOVÁ ◽

P. TRACHTA ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Fibroblast Growth ◽

Serum Concentrations ◽

Very Low Calorie Diet ◽

Low Calorie Diet ◽

Calorie Diet ◽

Fibroblast Growth Factor 19

The aim of our study was to measure serum concentrations of fibroblast growth factor 19 (FGF-19) in patients with obesity (OB), obesity and type 2 diabetes mellitus (T2DM) and healthy subjects (C) at baseline and after selected interventions. We measured serum FGF-19 levels and other biochemical and hormonal parameters in 29 OB and 19 T2DM females and 30 sex- and age-matched control subjects. The interventions were acute hyperinsulinemia during isoglycemic-hyperinsulinemic clamp (n=11 for T2DM and 10 for C), very-low calorie diet (VLCD, n=12 for OB) and 3 months treatment with PPAR-α agonist fenofibrate (n=11 for T2DM). Baseline serum FGF-19 levels were significantly lower in OB relative to C group (132.1±12.7 vs. 202.2±16.7 pg/ml, p<0.05), while no significant difference was observed between T2DM and OB or control group. Acute hyperinsulinemia tended to decrease FGF-19 levels in both healthy and T2DM subjects. Three weeks of VLCD in OB group had no significant effect on FGF-19, whereas three months of fenofibrate treatment markedly reduced FGF-19 levels in T2DM patients (194.58±26.2 vs. 107.47±25.0 pg/ml, p<0.05). We conclude that FGF-19 levels in our study were at least partially dependent upon nutritional status, but were not related to parameters of glucose metabolism or insulin sensitivity.

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