scholarly journals Sesquiterpene lactones from Cichorium endivia L. and C. intybus L. and cytotoxic activity.

1988 ◽  
Vol 36 (7) ◽  
pp. 2423-2429 ◽  
Author(s):  
MAMORU SETO ◽  
TOSHIO MIYASE ◽  
KAORU UMEHARA ◽  
AKIRA UENO ◽  
YUTAKA HIRANO ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Sesquiterpene Lactones ◽  
Cichorium Endivia

scholarly journals Sesquiterpene Lactones from Artemisia absinthium. Biotransformation and Rearrangement of the Insect Antifeedant 3α-hydroxypelenolide

Plants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 891
Author(s):  
Braulio M. Fraga ◽  
Carmen E. Díaz ◽  
María Bailén ◽  
Azucena González-Coloma
Keyword(s):  
Cytotoxic Activity ◽  
Leptinotarsa Decemlineata ◽  
Spodoptera Littoralis ◽  
Culture Medium ◽  
Insect Cells ◽  
Sesquiterpene Lactones ◽  
Enzymatic System ◽  
Artemisia Absinthium ◽  
Sf9 Insect Cells ◽  
New Compounds

Three new compounds, the sesquiterpenes absilactone and hansonlactone and the acetophenone derivative ajenjol, have been isolated from a cultivated variety of Artemisia absinthium. In addition, the major lactone isolated, 3α-hydroxypelenolide, was biotransformed by the fungus Mucor plumbeus affording the corresponding 1β, 10α-epoxide. A cadinane derivative was formed by an acid rearrangement produced in the culture medium, but not by the enzymatic system of the fungus. Furthermore, 3α-hydroxypelenolide showed strong antifeedant effects against Leptinotarsa decemlineata and cytotoxic activity to Sf9 insect cells, while the biotransformed compounds showed antifeedant postingestive effects against Spodoptera littoralis.

Cytotoxic activity of sesquiterpene lactones from Inula britannica on human cancer cell lines

2013 ◽  
Vol 6 (2) ◽  
pp. 246-252 ◽  
Author(s):  
Justin T. Fischedick ◽  
Milica Pesic ◽  
Ana Podolski-Renic ◽  
Jasna Bankovic ◽  
Ric C.H. de Vos ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Sesquiterpene Lactones ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Inula Britannica

scholarly journals Sesquiterpene Lactones from Inula oculus-christi

2010 ◽  
Vol 5 (4) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Mahmoud Mosaddegh ◽  
Maryam Hamzeloo Moghadam ◽  
Saeedeh Ghafari ◽  
Farzaneh Naghibi ◽  
Seyed Nasser Ostad ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Crystal Structures ◽  
Spectroscopic Data ◽  
Sesquiterpene Lactones ◽  
X Ray ◽  
X Ray Crystallography ◽  
First Time

Inula oculus-christi L. (Compositae) extract was chromatographed and three sesquiterpene lactones ergolide, gaillardin and pulchellin C were isolated. The structures of these compounds were determined by analysis of their spectroscopic data, and their crystal structures were defined using X-ray crystallography; the isolation of ergolide and pulchellin C is reported for the first time from this species. These three compounds were evaluated for their in vitro cytotoxic activity against MDBK, MCF7 and WEHI164 cells; ergolide and gaillardin exhibited lower and significantly different IC50 values compared with pulchellin C ( p<0.001).

UPLC/MS/MS method for quantification and cytotoxic activity of sesquiterpene lactones isolated from Saussurea lappa

2014 ◽  
Vol 155 (2) ◽  
pp. 1393-1397 ◽  
Author(s):  
Ashish Kumar ◽  
Shiv Kumar ◽  
Dharmesh Kumar ◽  
Vijai K. Agnihotri
Keyword(s):  
Cytotoxic Activity ◽  
Sesquiterpene Lactones ◽  
Saussurea Lappa

scholarly journals Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of Vernonia colorata

2009 ◽  
Vol 75 (1) ◽  
pp. 176-179 ◽  
Author(s):  
J.C. Chukwujekwu ◽  
C.A. Lategan ◽  
P.J. Smith ◽  
F.R. Van Heerden ◽  
J. Van Staden
Keyword(s):  
Cytotoxic Activity ◽  
Leaf Extract ◽  
Sesquiterpene Lactones

Sesquiterpene Lactones from the Roots ofFerula variaand Their Cytotoxic Activity

2007 ◽  
Vol 70 (12) ◽  
pp. 1915-1918 ◽  
Author(s):  
Kyoko Suzuki ◽  
Mamoru Okasaka ◽  
Yoshiki Kashiwada ◽  
Yoshihisa Takaishi ◽  
Gisho Honda ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Sesquiterpene Lactones

Cytotoxic activity of sesquiterpene lactones on breast cancer stem cells

2016 ◽  
Vol 69 ◽  
pp. S116-S117
Author(s):  
S. Wendy ◽  
V. Rodrigo ◽  
M. Atena ◽  
R. Gloria ◽  
A. Giovanna ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cytotoxic Activity ◽  
Sesquiterpene Lactones ◽  
Breast Cancer Stem Cells

Sesquiterpene lactones from Carpesium rosulatum with potential cytotoxicity against five human cancer cell lines

2010 ◽  
Vol 30 (8) ◽  
pp. 1083-1087 ◽  
Author(s):  
Hyung-In Moon ◽  
Okpyo Zee
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Sesquiterpene Lactone ◽  
Cell Lines ◽  
Human Cancer ◽  
Sesquiterpene Lactones ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Human Cancer Cells ◽  
Whole Plant

In search for plant-derived cytotoxicity compound against human cancer cells (A549, SK-OV-3, SK-MEL-2, XF498, HCT15), it was found that the chloroform extracts obtained from the whole plant of Carpesium rosulatum MlQ. (Compositae) exhibited significant cytotoxic activity. Four sesquiterpene lactone, CRC1 (2α, 5-epoxy-5,10-dihydroxy-6-angeloyl-oxy-9β-isobutyloxy-germacran-8α,12-olide), CRC2 (2α,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide), CRC3 (2α,5-epoxy-5,10-dihydroxy-6α-angeloyloxy-9β-(3-methyl-butanoyloxy)-gemacran-8α,12-olide), CRC4 (2β,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide) were isolated from the whole parts of C. rosulatum. 2α,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide (CRC2) showed the most potent cytotoxicity with IC50 value of 6.01 μM against SK-MEL-2.

scholarly journals Cytotoxic Sesquiterpene Lactones of Egyptian Tanacetum santolinoides

2007 ◽  
Vol 2 (8) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Diaa T. A. Youssef ◽  
Mahmoud A. Ramadan ◽  
Sabrin R. M. Ibrahim ◽  
Jihan M. Badr
Keyword(s):  
Cytotoxic Activity ◽  
Brine Shrimp ◽  
Nmr Spectra ◽  
Methanolic Extract ◽  
Soluble Fraction ◽  
Sesquiterpene Lactones ◽  
Natural Source ◽  
Mass Spectral ◽  
Aerial Parts ◽  
First Time

The chloroform soluble fraction of the methanolic extract of the aerial parts of Tanacetum santolinoides afforded six sesquiterpene lactones. Tanacetolide A (1) was isolated for the first time from a natural source, in addition to five known sesquiterpene lactones. The structures were established on the basis of extensive studies of their 1D and 2D (1H-1H COSY, HMQC, HMBC, HOHAHA and NOESY) NMR spectra and FAB mass spectral determinations. The compounds showed good cytotoxic activity when tested using the brine shrimp bioassay.

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