Molecular Interaction between Intercellular Lipids in the Stratum Corneum and <i>l</i>-Menthol, as Analyzed by Synchrotron X-Ray Diffraction

A harlequin fetus was born to unrelated parents with a negative family history for any form of ichthyosis. The child was grossly deformed, showing thick plaques on the cutaneous surface, and survived only 48 hours. Pathological studies of the skin showed marked thickening of the stratum corneum, but no other distinctive changes. X-ray diffraction analysis of the horny layer revealed the presence of a cross-β fibrous protein rather than the usual α-protein. The epithelial surface of other organs appeared normal. The thymus gland was involuted and showed changes in the corpuscles. Abnormalities were also observed in the conversion of cartilage to bone.

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Swelling of intercellular lipid lamellar structure with short repeat distance in hairless mouse stratum corneum as studied by X-ray diffraction

Chemistry and Physics of Lipids ◽

10.1016/s0009-3084(02)00126-3 ◽

2003 ◽

Vol 123 (1) ◽

pp. 1-8 ◽

Cited By ~ 56

Author(s):

Noboru Ohta ◽

Sadanori Ban ◽

Hiroshi Tanaka ◽

Satoru Nakata ◽

Ichiro Hatta

Keyword(s):

Stratum Corneum ◽

Lamellar Structure ◽

Hairless Mouse ◽

X Ray Diffraction ◽

Repeat Distance ◽

X Ray ◽

Short Repeat ◽

Intercellular Lipid

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Combined effects of ethanol and l-menthol on hairless rat stratum corneum investigated by synchrotron X-ray diffraction

Journal of Controlled Release ◽

10.1016/j.jconrel.2006.08.005 ◽

2006 ◽

Vol 115 (3) ◽

pp. 275-279 ◽

Cited By ~ 18

Author(s):

Yasuko Obata ◽

Ichiro Hatta ◽

Noboru Ohta ◽

Naomi Kunizawa ◽

Naoto Yagi ◽

...

Keyword(s):

Stratum Corneum ◽

Combined Effects ◽

X Ray Diffraction ◽

X Ray

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X-ray Diffraction Analysis of Stratum Corneum Membrane Couplets

Journal of Investigative Dermatology ◽

10.1111/1523-1747.ep12534362 ◽

1983 ◽

Vol 80 (3) ◽

pp. 213-214 ◽

Cited By ~ 49

Author(s):

Peter M. Elias ◽

Laurence Bonar ◽

Stephen Grayson ◽

Howard P. Baden

Keyword(s):

Stratum Corneum ◽

Diffraction Analysis ◽

X Ray Diffraction ◽

X Ray

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Estimating the Solubility, Solution Thermodynamics, and Molecular Interaction of Aliskiren Hemifumarate in Alkylimidazolium Based Ionic Liquids

Molecules ◽

10.3390/molecules24152807 ◽

2019 ◽

Vol 24 (15) ◽

pp. 2807 ◽

Cited By ~ 6

Author(s):

Md. Khalid Anwer ◽

Mohammad Muqtader ◽

Muzaffar Iqbal ◽

Raisuddin Ali ◽

Bjad K. Almutairy ◽

...

Keyword(s):

Ionic Liquids ◽

Molecular Interaction ◽

Solid Phase ◽

Solution Thermodynamics ◽

X Ray Diffraction ◽

Scanning Calorimetry ◽

X Ray ◽

Different Temperatures ◽

Phase Evaluation ◽

The Ideal

Estimating the solubility and solution thermodynamics parameters of aliskiren hemifumarate (AHF) in three different room temperature ionic liquids (RTILs), Transcutol-HP (THP) and water are interesting as there is no solubility data available in the literature. In the current study, the solubility and solution thermodynamics of AHF in three different RTILs, THP and water at the temperature range from 298.2 to 318.2 K under air pressure 0.1 MP were evaluated. The solid phase evaluation by Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction (PXRD) indicated no conversion of AHF into polymorph. The mole fraction solubility of AHF was found to be highest in 1-hexyl-3-methylimidazolium hexafluorophosphate (HMMHFP) ionic liquid (7.46 × 10−2) at 318.2 K. The obtained solubility values of AHF was regressed by the Apelblat and van’t Hoff models with overall root mean square deviations (RMSD) of 0.62% and 1.42%, respectively. The ideal solubility of AHF was higher compared to experimental solubility values at different temperatures. The lowest activity coefficient was found in HMMHFP, which confirmed highest molecular interaction between AHF–HMMHFP. The estimated thermodynamic parameters confirmed endothermic and entropy driven dissolution of AHF in different RTILs, THP, and water.

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