Pharmacological Studies of Houttuyniae Herba : The Anti-inflammatory Effect of Quercitrin

Objectives: The aim was to contribute to the promotion of medicinal plants used in Africa for management of asthma by analyzing their experimental pharmacological evaluation data. Methods: We carried out a systematic review of the literature based on the following research equations in English and in French: « médecine traditionnelle africaine » ET « asthma » ; « African traditional medicine » AND « asthma » or « Medicine African traditional » AND « asthma » ; « plantes médicinales » ET « asthma » ET « antispasmodique » ; «medicinal plants » AND « asthma » AND « anti-spasmodic » ; « plantes médicinales » ET « asthma » ET « anti-inflammatoire » ; «medicinal plants » AND « asthma » AND « anti-inflammatory ». Results: The study revealed 184 medicinal plants used in Africa for the treatment of asthma, 34 of which showed pharmacological properties in favor of their use. In animal experiments, 18 of these plants exerted a spasmolytic effect, 22 an anti-inflammatory effect and 6 both effects. The spasmolytic activity study protocols were based primarily on inhibition of smooth airway muscle contraction, including trachea, induced by various spasmogenic agents. As for of the methods used to study anti-inflammatory activity, the majority of them consisted of tests for carrageenan-induced edema or for formalin-induced leg irritation. Conclusion: Our results justify the need for standardization of experimental study protocols for the recovery of medicinal plants.

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Pharmacological studies of lumisantonin derivatives, with special reference to anti-inflammatory effect and to histamine-release inhibitory action

Folia Pharmacologica Japonica ◽

10.1254/fpj.56.1249 ◽

1960 ◽

Vol 56 (5) ◽

pp. 1249-1262 ◽

Cited By ~ 1

Author(s):

Hidemasa YAMASAKL ◽

Kazuji KONDO ◽

Teruo UDA ◽

Takashi YAMAMOTO ◽

Koiti ENDO

Keyword(s):

Histamine Release ◽

Special Reference ◽

Inhibitory Action ◽

Pharmacological Studies ◽

Anti Inflammatory ◽

Inflammatory Effect

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Pharmacological Studies on Herb Paeony Root. II. : Anti-inflammatory Effect, Inhibitory Effect on Gastric Juice Secretion, Preventive Effect on Stress Ulcer, Antidiuretic Effect of Paeoniflorin and Combined Effects with Licorice Component FM 100

YAKUGAKU ZASSHI ◽

10.1248/yakushi1947.89.7_887 ◽

1969 ◽

Vol 89 (7) ◽

pp. 887-892 ◽

Cited By ~ 28

Author(s):

KEIJIRO TAKAGI ◽

MASATOSHI HARADA

Keyword(s):

Gastric Juice ◽

Stress Ulcer ◽

Inhibitory Effect ◽

Combined Effects ◽

Preventive Effect ◽

Antidiuretic Effect ◽

Pharmacological Studies ◽

Gastric Juice Secretion ◽

Anti Inflammatory ◽

Inflammatory Effect

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Pharmacological studies of HAI-105. a new non-steroidal anti-inflammatory and analgesic drug (1) :anti-inflammatory effect on various animal inflammatory models.

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)38697-4 ◽

1991 ◽

Vol 55 ◽

pp. 230

Author(s):

Yasuaki Taniguchi ◽

Hiroshi Furukawa ◽

Yoshiki Deguchi ◽

Hidenao Minami ◽

Michinori Sakai ◽

...

Keyword(s):

Analgesic Drug ◽

Inflammatory Models ◽

Pharmacological Studies ◽

Anti Inflammatory ◽

Inflammatory Effect

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Synthesis of Limonin Derivatives with Improved Anti-inflammatory and Analgesic Properties

Letters in Drug Design & Discovery ◽

10.2174/1570180816666181113102359 ◽

2020 ◽

Vol 17 (3) ◽

pp. 285-299 ◽

Cited By ~ 2

Author(s):

Chengshu Jia ◽

Bin Hu ◽

Yingying Ji ◽

Yourui Su ◽

Guoqing Gong ◽

...

Keyword(s):

Furan Ring ◽

Biological Activities ◽

Aqueous Solubility ◽

Structural Modifications ◽

Pharmacological Studies ◽

Anti Inflammatory ◽

Analgesic Activities ◽

Ld50 Value ◽

Inflammatory Effect

Background: Limonoids represent an important class of natural products which possess a broad range of biological activities. Albeit their enormous potentials as therapeutic candidates, they usually suffer from low bioavailability, poor aqueous solubility and relatively weak biological activities which result in significant challenges in the clinic applications. Therefore, the exploration and development of novel limonin derivatives with improved drug-like properties through the structural modifications recently have attracted great attention in the biological and medicinal chemistry field. Methods: Based on the structural modifications of C17-furan ring in limonin, a series of limonin derivatives was designed, synthesized and screened for their anti-inflammatory and analgesic activities in vivo. Results and Conclusion: Preliminary pharmacological studies revealed that most tested compounds exhibited more potent anti-inflammatory and analgesic efficacies than lead molecule limonin. Especially, for compound 3f, it exhibited a stronger anti-inflammatory effect than that of naproxen and comparable analgesic potency with aspirin. In the formalin test, 3f showed an obviously attenuated phase-II pain response which indicated that it may produce an anti-inflammatory effect in the periphery. Furthermore, the significantly low hERG inhibition (IC50 >100 μM) and high LD50 value of target molecule 3f further demonstrated it as a promising analgesic/anti-inflammatory candidate with excellent drug-like profiles.

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Pharmacological Studies on the Anti-Inflammatory Effect of a Semi-Synthetic Polysaccharide (Pentosan Polysulfate)

Pharmacology ◽

10.1159/000136370 ◽

1973 ◽

Vol 9 (2) ◽

pp. 74-79 ◽

Cited By ~ 29

Author(s):

D.A. Kalbhen

Keyword(s):

Pentosan Polysulfate ◽

Pharmacological Studies ◽

Anti Inflammatory ◽

Inflammatory Effect

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Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000620 ◽

2019 ◽

pp. 1-9

Author(s):

Samira Salem ◽

Essaid Leghouchi ◽

Rachid Soulimani ◽

Jaouad Bouayed

Keyword(s):

Time Course ◽

Acute Inflammation ◽

Lichen Species ◽

Paw Edema ◽

Sod Activity ◽

Edema Formation ◽

Lobaria Pulmonaria ◽

Anti Inflammatory ◽

Endogenous Antioxidant ◽

Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

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