scholarly journals Review of Experimental Pharmacological Studies of Plants Used for Asthma Management in Africa

2020 ◽  
Vol 4 (2) ◽  
pp. 1-11
Author(s):  
Amenan Geneviève N’guessan-Irié ◽  
Keyword(s):  
Medicinal Plants ◽  
Animal Experiments ◽  
Asthma Management ◽  
Plantes Médicinales ◽  
Review Of The Literature ◽  
Spasmolytic Activity ◽  
Study Protocols ◽  
Pharmacological Studies ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Objectives: The aim was to contribute to the promotion of medicinal plants used in Africa for management of asthma by analyzing their experimental pharmacological evaluation data. Methods: We carried out a systematic review of the literature based on the following research equations in English and in French: « médecine traditionnelle africaine » ET « asthma » ; « African traditional medicine » AND « asthma » or « Medicine African traditional » AND « asthma » ; « plantes médicinales » ET « asthma » ET « antispasmodique » ; «medicinal plants » AND « asthma » AND « anti-spasmodic » ; « plantes médicinales » ET « asthma » ET « anti-inflammatoire » ; «medicinal plants » AND « asthma » AND « anti-inflammatory ». Results: The study revealed 184 medicinal plants used in Africa for the treatment of asthma, 34 of which showed pharmacological properties in favor of their use. In animal experiments, 18 of these plants exerted a spasmolytic effect, 22 an anti-inflammatory effect and 6 both effects. The spasmolytic activity study protocols were based primarily on inhibition of smooth airway muscle contraction, including trachea, induced by various spasmogenic agents. As for of the methods used to study anti-inflammatory activity, the majority of them consisted of tests for carrageenan-induced edema or for formalin-induced leg irritation. Conclusion: Our results justify the need for standardization of experimental study protocols for the recovery of medicinal plants.

scholarly journals Pharmacological Studies of Houttuyniae Herba : The Anti-inflammatory Effect of Quercitrin

1993 ◽  
Vol 113 (4) ◽  
pp. 327-333 ◽  
Author(s):  
Kyoji TAGUCHI ◽  
Yukihiko HAGIWARA ◽  
Kazuyo KAJIYAMA ◽  
Yukiko SUZUKI
Keyword(s):  
Pharmacological Studies ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The Pharmacological and Pathological Studies on Taiwan Folk Medicine (VII): The Anti-inflammatory Effect of Echinops grjiisii

1992 ◽  
Vol 20 (02) ◽  
pp. 127-134 ◽  
Author(s):  
Chun-Ching Lin ◽  
Cheng-hung Lin ◽  
Hui-Fen Chiu ◽  
Min-Fu Hu
Keyword(s):  
Methanolic Extract ◽  
Folk Medicine ◽  
Animal Experiments ◽  
Active Principle ◽  
Chloroform Fraction ◽  
Protective Effects ◽  
Active Components ◽  
Crude Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The hepatotoxic-protective effects of "San-fang-feng" (the root of E. grijisii) and "Lou-lu" (the root of E. latifolius) on CCl 4 induced hepatotoxicity have been proposed in our previous paper (Lin et al, 1990). The anti-inflammatory effects of these two crude drugs were investigated in this experiment. The results indicated that both of them displayed pronounced anti-inflammatory activities against carrageenan-induced edema. Furthermore, in order to isolated the main active components of E. grijisii, fractions obtained from the methanolic extract of E. grijisii were investigated in mice for their 24-h LD 50 and 95% confidence limits, which could be used as a guiding for further animal experiments. Our findings demonstrated that n-hexane (100,300 mg/kg), chloroform (30,100,300 mg/kg) and ethyl acetate (30,100, 300 mg/kg) fractions could markedly inhibit the carrageenan-induced inflammation, and the main active principle was found to be concentrated in the chloroform fraction, which possessed significant inhibitory activities even more than does indomethacin.

scholarly journals A Systematic Review for Anti-Inflammatory Property of Clusiaceae Family: A Preclinical Approach

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Mônica Santos de Melo ◽  
Jullyana de Souza Siqueira Quintans ◽  
Adriano Antunes de Souza Araújo ◽  
Marcelo Cavalcante Duarte ◽  
Leonardo Rigoldi Bonjardim ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Experiments ◽  
Final Analysis ◽  
Inflammatory Activity ◽  
Bibliographic Databases ◽  
Edema Formation ◽  
Search Terms ◽  
Anti Inflammatory ◽  
Pharmacological Potential ◽  
Inflammatory Effect

Background.Clusiaceae family (sensu lato) is extensively used in ethnomedicine for treating a number of disease conditions which include cancer, inflammation, and infection. The aim of this review is to report the pharmacological potential of plants of Clusiaceae family with the anti-inflammatory activity in animal experiments.Methods.A systematic review about experiments investigating anti-inflammatory activity of Clusiaceae family was carried out by searching bibliographic databases such as Medline, Scopus and Embase. In this update, the search terms were “anti-inflammatory agents,” “Clusiaceae,” and “animals, laboratory.”Results.A total of 255 publications with plants this family were identified. From the initial 255 studies, a total of 21 studies were selected for the final analysis. Studies with generaAllanblackia,Clusia,GarciniaorRheedia, andHypericumshowed significant anti-inflammatory activity. The findings include a decrease of total leukocytes, a number of neutrophils, total protein concentration, granuloma formation, and paw or ear edema formation. Other interesting findings included decreased of the MPO activity, and inflammatory mediators such as NF-κB and iNOS expression, PGE2and Il-1βlevels and a decrease in chronic inflammation.Conclusion.The data reported suggests the anti-inflammatory effect potential of Clusiaceae family in animal experiments.

scholarly journals AN UPDATED PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW ON GYNURA PROCUMBENS

2019 ◽  
pp. 9-14 ◽  
Author(s):  
KAMRAN ASHRAF
Keyword(s):  
Experimental Data ◽  
Side Effects ◽  
Medicinal Plants ◽  
Medicinal Plant ◽  
Traditional Medicine ◽  
Therapeutic Potential ◽  
Therapeutic Uses ◽  
Pharmacological Studies ◽  
Anti Inflammatory ◽  
Effective Drugs

Nowadays, the use of medicinal plants increased significantly for the aim of producing more effective drugs with fewer side effects. Gynura procumbens (family Asteraceae) is a high value medicinal plant with different properties that are considered less, regardless of having great therapeutic potential in traditional medicine. Many pharmacological studies have established the ability of this plant to exhibit antimicrobial, antioxidant, hepatoprotection, antigenotoxic, antiplasmodial, cytotoxic, cardioactive, antidiabetic, anti-inflammatory, etc. The aim of this study was to review the updated phytochemical, pharmacological investigations as well as the traditional and therapeutic uses of G. procumbens. Important and different experimental data have been addressed along with a review of most of the phytochemicals identified in this plant.

Anti-inflammatory effect of Mongolia and Vietnamese medicinal plants against LPS-induced NO release in the RAW 264.7 cell

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
QH Juan ◽  
T Batmunkh ◽  
DT Nga ◽  
S Eun-Mi ◽  
YH Joo ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Raw 264.7 ◽  
Raw 264.7 Cell ◽  
No Release ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract of Leonotis ocymifolia (Burm.f.) Iwarsson Leaves in Rodent Models

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Asnakech Alemu ◽  
Wondmagegn Tamiru ◽  
Teshome Nedi ◽  
Workineh Shibeshi
Keyword(s):  
Acetic Acid ◽  
Medicinal Plants ◽  
Analgesic Effect ◽  
Rodent Models ◽  
Paw Edema ◽  
Traditional Remedies ◽  
Latency Response ◽  
Anti Inflammatory ◽  
Dose Levels ◽  
Inflammatory Effect

Background. Pain and inflammation are the major health problems commonly treated with traditional remedies mainly using medicinal plants. Leonotis ocymifolia is one of such medicinal plants used in folkloric medicine of Ethiopia. However, the plant has not been scientifically evaluated. The aim of this study was to evaluate analgesic and anti-inflammatory effects of the 80% methanol leaves extract of Leonotis ocymifolia using rodent models. Method. The central and peripheral analgesic effect of the extract at 100, 200, and 400 mg/kg dose levels was evaluated using hot plate and acetic acid induced writhing rodent models, whereas carrageenan induced paw edema and cotton pellet granuloma methods were used to screen anti-inflammatory effect of the extract at the same dose levels. Acute toxicity test was also done. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test and p<0.05 was considered significant. Results. The extract did not produce mortality up to 2000 mg/kg. All tested doses of the extract showed significant analgesic effect with maximum latency response of 62.8% and inhibition of acetic acid induced writhing. Maximum anti-inflammatory effect was recorded at 6 h after induction, with 75.88% reduction in carrageenan induced paw edema. Moreover, all tested doses of extract significantly inhibited the formation of inflammatory exudates and granuloma formation (p<0.001). Conclusion. The study indicated that the extract was safe in mice and it has both analgesic and anti-inflammatory effect in rodent models.

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