scholarly journals Pharmacological Studies on Herb Paeony Root. II. : Anti-inflammatory Effect, Inhibitory Effect on Gastric Juice Secretion, Preventive Effect on Stress Ulcer, Antidiuretic Effect of Paeoniflorin and Combined Effects with Licorice Component FM 100

1969 ◽  
Vol 89 (7) ◽  
pp. 887-892 ◽  
Author(s):  
KEIJIRO TAKAGI ◽  
MASATOSHI HARADA
Keyword(s):  
Gastric Juice ◽  
Stress Ulcer ◽  
Inhibitory Effect ◽  
Combined Effects ◽  
Preventive Effect ◽  
Antidiuretic Effect ◽  
Pharmacological Studies ◽  
Gastric Juice Secretion ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-Inflammatory Effect of Lycii radicis in LPS-Stimulated RAW 264.7 Macrophages

2014 ◽  
Vol 42 (04) ◽  
pp. 891-904 ◽  
Author(s):  
Mi Young Song ◽  
Hyo Won Jung ◽  
Seok Yong Kang ◽  
Kyung-Ho Kim ◽  
Yong-Ki Park
Keyword(s):  
Inflammatory Cytokines ◽  
Inflammatory Mediators ◽  
Water Extract ◽  
Inhibitory Effect ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Root Bark ◽  
Lycium Barbarum ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The root bark of Lycium barbarum (Lycii radicis cortex, LRC) is used as a cooling agent for fever and night sweats in East Asian traditional medicine. The inhibitory effect of LRC water extract on inflammation is unknown. In this study, the anti-inflammatory effect of LRC was investigated in lipopolysaccharide (LPS)-stimulated mouse macrophage, RAW 264.7 cells. LRC extract significantly decreased the LPS-induced production of inflammatory mediators, nitric oxide (NO), prostaglandin (PG) E2 and pro-inflammatory cytokines, interleukin (IL)-1β and IL-6 in the cells. In addition, LRC extract inhibited the LPS-induced expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 mRNA and protein, and inflammatory cytokines mRNA in the cells. The action mechanism of LRC underlies the blocking of LPS-mediated p38 and Jun N-terminal kinase (JNK), mitogen-activated protein kinases (MAPKs), and the nuclear factor (NF)-κB signaling pathway. These results indicate that LRC extract inhibits the inflammatory response in activated macrophages by down-regulating the transcription levels of inflammatory mediators and blocking the MAPKs and NF-κB pathway.

In Vitro and In Vivo Anti-Inflammatory Activity of the Rhizomes of Globba pendula Roxb

2021 ◽  
Vol 16 (10) ◽  
pp. 1934578X2110559
Author(s):  
Le Minh Ha ◽  
Ngo Thi Phuong ◽  
Nguyen Thi Thu Hien ◽  
Pham Thi Tam ◽  
Do Thi Thao ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Inhibitory Effect ◽  
Potential Effect ◽  
Inflammatory Activity ◽  
No Production ◽  
Anti Inflammatory ◽  
Inflammatory Effect

In this study, we aimed at evaluating in vitro and in vivo anti-inflammatory activity of various extracts of the rhizomes of Globba pendula Roxb. Three extracts ( n-hexane, ethyl acetate, and water) were screened for their inhibitory effect on NO production by lipopolysaccharide-stimulated RAW 264.7 macrophages. The ethyl acetate extract of G. pendula rhizomes (EGP) showed a potential effect with an IC50 value of 32.45 µg/mL. For in vivo study, the ethyl acetate extract was further investigated for its anti-inflammatory effect using collagen antibody-induced arthritic mice (CAIA). The level of arthritis in experimental mice significantly reduced ( P < .05) after treatment with EGP at a dose of 500 mg/kg body weight (b.w.). This study also revealed that EGP is orally non-toxic. Ethyl p-methoxy cinamate was identified as the main constituent of EGP, which may result in its anti-inflammatory effect.

scholarly journals Pharmacological Studies of Houttuyniae Herba : The Anti-inflammatory Effect of Quercitrin

1993 ◽  
Vol 113 (4) ◽  
pp. 327-333 ◽  
Author(s):  
Kyoji TAGUCHI ◽  
Yukihiko HAGIWARA ◽  
Kazuyo KAJIYAMA ◽  
Yukiko SUZUKI
Keyword(s):  
Pharmacological Studies ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Anti-Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNK/NF-κB Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Yao Li ◽  
Yang Liu ◽  
Qian Yang ◽  
Zhihui Shi ◽  
Yanhua Xie ◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Genital Tract ◽  
Nuclear Translocation ◽  
Immunohistochemical Analysis ◽  
Dependent Manner ◽  
Preventive Effect ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
Inflammatory Effect

Objectives. In this study, we aimed to illustrate the preventive effect and possible mechanisms of Feiyangchangweiyan capsule (FYCWYC) on rat pelvic inflammatory disease (PID) model. Methods. To construct the rat PID model, upper genital tract was infected by multipathogen, and then drugs were orally administered for 8 days. The histological examination, immunohistochemical analysis, and ELISA were carried out. Furthermore, Western blotting was used to analyze the expression of Akt, MAPKs, NF-κB p65, and IκB-α in uterus. Results. As the results showed, infiltrations of neutrophils and lymphocytes in uterus were significantly suppressed, and IL-1β, IL-6, CXCL-1, and TNF-α were also reduced in a dose-dependent manner. We also found that FYCWYC inhibited apoptosis induced by infection. Furthermore, FYCWYC could block the infection-induced nuclear translocation of NF-κB. We found that FYCWYC treatment only decreased the phosphorylation of JNK induced by infection and had no effects on Akt and P38. Additional, the effects of SP600125, an inhibitor of phospho-JNK, were similar to the results of FYCWYC. Conclusions. Taken together, our results demonstrated that FYCWYC had anti-inflammatory effect in pathogen-induced PID model, and the mechanism might be through inhibiting NF-κB nuclear translocation which is mediated by JNK.

scholarly journals Review of Experimental Pharmacological Studies of Plants Used for Asthma Management in Africa

2020 ◽  
Vol 4 (2) ◽  
pp. 1-11
Author(s):  
Amenan Geneviève N’guessan-Irié ◽  
Keyword(s):  
Medicinal Plants ◽  
Animal Experiments ◽  
Asthma Management ◽  
Plantes Médicinales ◽  
Review Of The Literature ◽  
Spasmolytic Activity ◽  
Study Protocols ◽  
Pharmacological Studies ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Objectives: The aim was to contribute to the promotion of medicinal plants used in Africa for management of asthma by analyzing their experimental pharmacological evaluation data. Methods: We carried out a systematic review of the literature based on the following research equations in English and in French: « médecine traditionnelle africaine » ET « asthma » ; « African traditional medicine » AND « asthma » or « Medicine African traditional » AND « asthma » ; « plantes médicinales » ET « asthma » ET « antispasmodique » ; «medicinal plants » AND « asthma » AND « anti-spasmodic » ; « plantes médicinales » ET « asthma » ET « anti-inflammatoire » ; «medicinal plants » AND « asthma » AND « anti-inflammatory ». Results: The study revealed 184 medicinal plants used in Africa for the treatment of asthma, 34 of which showed pharmacological properties in favor of their use. In animal experiments, 18 of these plants exerted a spasmolytic effect, 22 an anti-inflammatory effect and 6 both effects. The spasmolytic activity study protocols were based primarily on inhibition of smooth airway muscle contraction, including trachea, induced by various spasmogenic agents. As for of the methods used to study anti-inflammatory activity, the majority of them consisted of tests for carrageenan-induced edema or for formalin-induced leg irritation. Conclusion: Our results justify the need for standardization of experimental study protocols for the recovery of medicinal plants.

scholarly journals Triptolide’s anti-inflammatory effects on ARDS by down-regulating miR-9-5p and up-regulating LRG1 and CLDN5

2021 ◽  
Author(s):  
Junyong Han ◽  
Huiqing Que ◽  
Wei Li ◽  
Shijie Xue ◽  
Sui Lin ◽  
...  
Keyword(s):  
Target Genes ◽  
Distress Syndrome ◽  
Inhibitory Effect ◽  
Active Components ◽  
Whole Transcriptome Sequencing ◽  
Life Threatening ◽  
Anti Inflammatory ◽  
Whole Transcriptome ◽  
Inflammatory Effect

Abstract Background Acute respiratory distress syndrome (ARDS) is a life-threatening respiratory disease and its treatment is not fully established. Triptolide, one of Tripterygium wilfordii’s main active components, has been proved to alleviate Lipopolysaccharide (LPS)-induced ARDS. Imbalance of MicroRNAs (miRNAs) is recognized as the pathogenic mechanism of various diseases, including ARDS. However, the specific miRNAs that play a key regulatory role in the anti-inflammatory effect of triptolide in ARDS remain elusive. Methods In this study, we administered triptolide in a mouse model of ARDS, and whole transcriptome sequencing was applied to identify meaningful miRNAs and validate them in vitro. Results The results showed that triptolide may reduce the inflammatory response in ARDS by regulating miR-9-5p. The data further proved that LRG1 and CLDN5 expression are regulated by miR-9-5p, and triptolide can down-regulate the expression of miR-9-5p by regulating negatively the expression of LRG1 and CLDN5. Conclusion Our study revealed that miR-9-5p was the specific miRNAs that plays key role in triptolide’s alleviation of ARDS inflammation by regulating target genes, and its inhibitory effect on LRG1 and CLDN5 expression was verified.

scholarly journals Inhibitory Effect ofHelicteres gardnerianaEthanol Extract on Acute Inflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Juliana Oliveira de Melo ◽  
Laura Lícia Milani de Arruda ◽  
Silmara Baroni ◽  
Maria da Conceição Torrado Truiti ◽  
Silvana Martins Caparroz-Assef ◽  
...  
Keyword(s):  
Acute Inflammation ◽  
Pleural Cavity ◽  
Ethanol Extract ◽  
Inhibitory Effect ◽  
Experimental Models ◽  
Perivascular Space ◽  
Polymorphonuclear Cells ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The anti-inflammatory effect of an ethanol extract ofHelicteres gardneriana(Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculationin situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500 mg/kg). These data demonstrate the anti-inflammatory effect of the ethanol extract ofHelicteres gardnerianaand imply that inhibition of leukocyte-endothelial interactions is important in the extract's mechanism of action.

Sign in / Sign up

Export Citation Format

Share Document