935 SHORT-TERM EFFECTS OF LOW FAT DIET ON SERUM CHOLESTEROL

1993 ◽  
Vol 25 (Supplement) ◽  
pp. S167
Author(s):  
M. A. Green ◽  
C. Foster ◽  
K. Kwak
Keyword(s):  
Serum Cholesterol ◽  
Low Fat ◽  
Short Term ◽  
Low Fat Diet ◽  
Short Term Effects

scholarly journals Short term effects of different omega-3 fatty acid formulation on lipid metabolism in mice fed high or low fat diet

2012 ◽  
Vol 11 (1) ◽  
pp. 70 ◽  
Author(s):  
Xiao Tang ◽  
Zhao-Jie Li ◽  
Jie Xu ◽  
Yong Xue ◽  
Jin-Zhang Li ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
Omega 3 ◽  
Low Fat ◽  
Short Term ◽  
Omega 3 Fatty Acid ◽  
Low Fat Diet ◽  
Acid Formulation ◽  
Short Term Effects

scholarly journals Short-term Effects of Different Fish Oil Formulations on Tissue Absorption of Docosahexaenoic Acid in Mice Fed High- and Low-Fat Diets

2013 ◽  
Vol 62 (11) ◽  
pp. 883-891 ◽  
Author(s):  
Ning Ding ◽  
Yong Xue ◽  
Xiao Tang ◽  
Zhao-Min Sun ◽  
Teruyoshi Yanagita ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Fish Oil ◽  
Low Fat ◽  
Short Term ◽  
Fat Diets ◽  
Short Term Effects

Abstract 128: Short-Term, High-Saturated and Trans Fatty Acid Diet Increases Expression of Key Intestinal Genes Involved in Lipoprotein Metabolism in Healthy Males

2012 ◽  
Vol 32 (suppl_1) ◽  
Author(s):  
André J Tremblay ◽  
Benoit Lamarche ◽  
Valerie Guay ◽  
Valery Lemelin ◽  
Patrick Couture
Keyword(s):  
Fatty Acids ◽  
Apolipoprotein B ◽  
High Fat Diet ◽  
Plasma Lipid ◽  
Lipoprotein Metabolism ◽  
High Fat ◽  
Low Fat ◽  
Short Term ◽  
Low Fat Diet ◽  
Key Genes

Dietary saturated fat (SFA) and trans fatty acids (TFA) have been linked to an increased risk of cardiovascular disease mainly by increasing plasma LDL-C levels. The modulation of cholesterol and fatty acids homeostasis by SFA and TFA is thought to be mediated by changes in expression of key intestinal genes involved in lipid and lipoprotein metabolism. However, the short-term impact of dietary fat intake on expression of these genes has not been fully investigated. To test whether short-term changes in SFA and TFA intake affects expression of key intestinal genes involved in lipid and lipoprotein metabolism, we conducted a randomized, double-blind, cross-over study using an intensive dietary modification in 12 nonobese healthy men with normal plasma lipid profile. Participants were subjected to 2 isocaloric 3-day diets: 1) high-fat diet (37% energy from fat, 15% from SFA, 3.5% from TFA and 50% energy from carbohydrate) and 2) low-fat diet (25% energy from fat, 6% from SFA, 0% from TFA and 62% energy from carbohydrate) in random order, each separated by a two-week washout period. Fasting plasma lipid levels were determined and expression of key genes involved in lipid and lipoprotein metabolism was compared by real-time PCR quantification in duodenal biopsy specimens obtained in the fasted state after 3 days of feeding on each diet. Following the 3-day high-fat diet, plasma-C (+7.4%, P=0.02), LDL-C (+16.9%, P=0.005) and HDL-C (+9.3%, P=0.002) levels were significantly increased as compared to low-fat diet. Plasma triglycerides (-31.7%, P=0.001) and apolipoprotein B-48 (-39.6%, P=0.003) levels were significantly decreased after the high-fat diet relative to the low-fat diet. The high-fat diet also resulted in significant increases in intestinal mRNA expression levels of SREBP-2, HNF-4α, PPAR-α, PPAR-γ, NPC1L1, ABCG8, FABP-2, ACAC-α, SCD-1, ELOVL5, DGAT-2, apolipoprotein B, MTTP, SAR1β and LDL receptor. These findings suggest that short-term exposure to a high-SFA and TFA diet upregulates the expression of key genes involved in lipid and lipoprotein metabolism at the enterocyte level.

Serum Apolipoprotein and Lipid Profile Effects of an Oat-Bran-Supplemented, Low-Fat Diet in Children with Elevated Serum Cholesterol

1991 ◽  
Vol 623 (1 Hyperlipidemi) ◽  
pp. 429-431 ◽  
Author(s):  
KURT GOLD ◽  
NATHAN WONG ◽  
ALAN TONG ◽  
STANLEY BASSIN ◽  
CYNTHIA IFTNER ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Serum Cholesterol ◽  
Elevated Serum ◽  
Low Fat ◽  
Low Fat Diet ◽  
Oat Bran ◽  
Elevated Serum Cholesterol

scholarly journals Flow-mediated vasodilation is not impaired when HDL-cholesterol is lowered by substituting carbohydrates for monounsaturated fat

2001 ◽  
Vol 86 (2) ◽  
pp. 181-188 ◽  
Author(s):  
Nicole M. de Rose ◽  
Michiel L. Bots ◽  
Els Siebelink ◽  
Evert Schouten ◽  
Martijin B. Katan
Keyword(s):  
Serum Cholesterol ◽  
Ldl Cholesterol ◽  
Saturated Fat ◽  
Hdl Cholesterol ◽  
Monounsaturated Fat ◽  
Low Fat ◽  
Low Fat Diet ◽  
Fat Diets ◽  
Flow Mediated Vasodilation ◽  
Stable Flow

Low-fat diets, in which carbohydrates replace some of the fat, decrease serum cholesterol. This decrease is due to decreases in LDL-cholesterol but in part to possibly harmful decreases in HDL-cholesterol. High-oil diets, in which oils rich in monounsaturated fat replace some of the saturated fat, decrease serum cholesterol mainly through LDL-cholesterol. We used these two diets to investigate whether a change in HDL-cholesterol would change flow-mediated vasodilation, a marker of endothelial function. We fed thirty-two healthy volunteers two controlled diets in a 2×3·5 weeks' randomised cross-over design to eliminate variation in changes due to differences between subjects. The low-fat diet contained 59·7 % energy (en%) as carbohydrates and 25·7 en% as fat (7·8 en% as monounsaturates); the oil-rich diet contained 37·8 en% as carbohydrates and 44·4 en% as fat (19·3 en% as monounsaturates). Average (SD) SERUM HDL-CHOLESTEROL AFTER THE LOW-FAT DIET WAS 0·21 (sd 0·12) mmol/l (8·1 mg/dl) lower than after the oil-rich diet. Serum triacylglycerols were 0·22 (sd 0·28) mmol/l (19·5 mg/dl) higher after the low-fat diet than after the oil-rich diet. Serum LDL and homocysteine concentrations remained stable. Flow-mediated vasodilation was 4·8 (SD 2·9) after the low-fat diet and 4·1 (SD 2·7) after the oil-rich diet (difference 0·7 %; 95 % CI -0·6, 1·9). Thus, although the low-fat diet produced a lower HDL-cholesterol than the high-oil diet, flow-mediated vasodilation, an early marker of cardiovascular disease, was not impaired.

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