Altered Chemoreflex Sensitivity in Young Adult Males with Obstructive Sleep Apnea during Graded Exercise Testing

2006 ◽  
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John M. Gregg ◽  
William G. Herbert
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Adrian Aron ◽  
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John M. Gregg ◽  
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Loop gain and the arousal threshold during non-rapid eye movement (NREM) sleep are greater in the morning compared with the afternoon and evening. Loop gain measures are correlated to chemoreflex sensitivity and the critical closing pressure measured during NREM sleep in the evening, morning, and afternoon. Breathing (in)stability and efficaciousness of treatments for obstructive sleep apnea may be modulated by a circadian rhythmicity in loop gain and the arousal threshold.


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Vol 42 (Supplement_1) ◽  
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