Influence Of Inspiratory Muscle Training On Pulmonary O2 Uptake Kinetics And Exercise Tolerance In Humans

Regardless of the management regime for heart failure (HF), there is strong evidence supporting the early implementation of exercise-based cardiac rehabilitation (CR). Respiratory therapy is considered to be an integral part of such secondary prevention protocols. The aim of the study was to evaluate the effect of inspiratory muscle training (IMT) on exercise tolerance and the functional parameters of the respiratory system in patients with heart failure involved in cardiac rehabilitation. The study included 90 patients with HF who took part in the second-stage 8-week cycle of cardiac rehabilitation (CR). They were randomly divided into three groups: Group I underwent CR and IMT; Group II only CR; and patients in Group III underwent only the IMT. Before and after the 8-week cycle, participants were assessed for exercise tolerance and the functional parameters of respiratory muscle strength. Significant statistical improvement concerned the majority of the hemodynamic parameters, lung function parameters, and respiratory muscle strength in the first group. Moreover, the enhancement in the exercise tolerance in the CR + IMT group was accompanied by a negligible change in the HRpeak. The results confirm that the addition of IMT to the standard rehabilitation process of patients with heart failure can increase the therapeutic effect while influencing some of the parameters measured by exercise electrocardiography and respiratory function.

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Inspiratory Muscle Training Potentiates the Beneficial Effects of Proportional Assisted Ventilation on Exertional Dyspnea and Exercise Tolerance in COPD: A Proof-of-Concept Randomized and Controlled Trial

COPD Journal of Chronic Obstructive Pulmonary Disease ◽

10.1080/15412555.2020.1789085 ◽

2020 ◽

Vol 17 (4) ◽

pp. 384-391

Author(s):

Rodrigo Koch ◽

Tiago Rodrigues de Lemos Augusto ◽

Alessandro Gomes Ramos ◽

Paulo de Tarso Müller

Keyword(s):

Exercise Tolerance ◽

Controlled Trial ◽

Assisted Ventilation ◽

Inspiratory Muscle ◽

Inspiratory Muscle Training ◽

Proof Of Concept ◽

Muscle Training ◽

Exertional Dyspnea ◽

Beneficial Effects

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Inspiratory Muscle Training Improves Exercise Tolerance and Attenuates Inspiratory Muscle Fatigue and the Perception of Dyspnea in Asthmatic Individuals.

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000323644.84472.4c ◽

2008 ◽

Vol 40 (Supplement) ◽

pp. S305 ◽

Cited By ~ 1

Author(s):

Tim D. Mickleborough ◽

Louise A. Turner ◽

Sandra Tecklenburg ◽

Joel M. Stager ◽

Martin R. Lindley ◽

...

Keyword(s):

Muscle Fatigue ◽

Exercise Tolerance ◽

Inspiratory Muscle ◽

Inspiratory Muscle Training ◽

Muscle Training ◽

Inspiratory Muscle Fatigue

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The effect of specific inspiratory muscle training on the sensation of dyspnea and exercise tolerance in patients with congestive heart failure

Clinical Cardiology ◽

10.1002/clc.4960221110 ◽

1999 ◽

Vol 22 (11) ◽

pp. 727-732 ◽

Cited By ~ 52

Author(s):

Paltiel Weiner ◽

Rasmi Magadle ◽

Noa Berar-Yanay ◽

Benny Pelled

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Exercise Tolerance ◽

Inspiratory Muscle ◽

Inspiratory Muscle Training ◽

Muscle Training

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Inspiratory muscle training enhances pulmonary O2 uptake kinetics and high-intensity exercise tolerance in humans

Journal of Applied Physiology ◽

10.1152/japplphysiol.00077.2010 ◽

2010 ◽

Vol 109 (2) ◽

pp. 457-468 ◽

Cited By ~ 52

Author(s):

Stephen J. Bailey ◽

Lee M. Romer ◽

James Kelly ◽

Daryl P. Wilkerson ◽

Fred J. DiMenna ◽

...

Keyword(s):

Blood Flow ◽

Muscle Fatigue ◽

Exercise Tolerance ◽

Slow Component ◽

Inspiratory Muscle ◽

Inspiratory Muscle Training ◽

Muscle Training ◽

Maximal Intensity ◽

Physiological Variables ◽

Inspiratory Muscle Fatigue

Fatigue of the respiratory muscles during intense exercise might compromise leg blood flow, thereby constraining oxygen uptake (V̇o2) and limiting exercise tolerance. We tested the hypothesis that inspiratory muscle training (IMT) would reduce inspiratory muscle fatigue, speed V̇o2 kinetics and enhance exercise tolerance. Sixteen recreationally active subjects (mean ± SD, age 22 ± 4 yr) were randomly assigned to receive 4 wk of either pressure threshold IMT [30 breaths twice daily at ∼50% of maximum inspiratory pressure (MIP)] or sham treatment (60 breaths once daily at ∼15% of MIP). The subjects completed moderate-, severe- and maximal-intensity “step” exercise transitions on a cycle ergometer before (Pre) and after (Post) the 4-wk intervention period for determination of V̇o2 kinetics and exercise tolerance. There were no significant changes in the physiological variables of interest after Sham. After IMT, baseline MIP was significantly increased (Pre vs. Post: 155 ± 22 vs. 181 ± 21 cmH2O; P < 0.001), and the degree of inspiratory muscle fatigue was reduced after severe- and maximal-intensity exercise. During severe exercise, the V̇o2 slow component was reduced (Pre vs. Post: 0.60 ± 0.20 vs. 0.53 ± 0.24 l/min; P < 0.05) and exercise tolerance was enhanced (Pre vs. Post: 765 ± 249 vs. 1,061 ± 304 s; P < 0.01). Similarly, during maximal exercise, the V̇o2 slow component was reduced (Pre vs. Post: 0.28 ± 0.14 vs. 0.18 ± 0.07 l/min; P < 0.05) and exercise tolerance was enhanced (Pre vs. Post: 177 ± 24 vs. 208 ± 37 s; P < 0.01). Four weeks of IMT, which reduced inspiratory muscle fatigue, resulted in a reduced V̇o2 slow-component amplitude and an improved exercise tolerance during severe- and maximal-intensity exercise. The results indicate that the enhanced exercise tolerance observed after IMT might be related, at least in part, to improved V̇o2 dynamics, presumably as a consequence of increased blood flow to the exercising limbs.

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