scholarly journals Heart-Lung Interaction and Its Prognostic Significance in Heart Failure Patients With Preserved Ejection Fraction

2021 ◽  
Author(s):  
Morihiko Takeda ◽  
Nobuyuki Shiba
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Prognostic Significance ◽  
Preserved Ejection Fraction ◽  
Heart Failure Patients

scholarly journals Subclinical Hypothyroidism and Its Association with Increased Cardiovascular Mortality

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Alvaro Altamirano Ufion ◽  
Beenish Zulfiqar ◽  
Abdalla Hassan ◽  
Roshanak Habibi ◽  
Prajwal Boddu
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Cardiovascular Mortality ◽  
Subclinical Hypothyroidism ◽  
Hormone Replacement ◽  
Prognostic Significance ◽  
Thyroid Stimulating Hormone ◽  
Current Evidence ◽  
Preserved Ejection Fraction ◽  
Heart Failure Patients

Thyroid hormones play an important role in regulating different metabolism functions and multiple organs’ performance. Changes in the thyroid hormone axis can lead to profound effects on the stability of vital organs and systems, especially the cardiovascular system. Hypothyroidism is classified according to the clinical presentation as overt and subclinical. There is some evidence supporting the benefits of thyroxine hormone replacement for subclinical hypothyroidism on cardiovascular mortality outcomes. However, the clinical relevance of measuring and treating high thyroid-stimulating hormone (TSH) levels in newly diagnosed heart failure patients with preserved ejection fraction requires further study. In this report, we review the current evidence regarding the prognostic significance of subclinical hypothyroidism in heart failure patients with preserved ejection fraction.

Galectin-3 in Heart Failure – Linking Fibrosis, Remodelling and Progression

2010 ◽  
Vol 6 (2) ◽  
pp. 33 ◽  
Author(s):  
Christopher R deFilippi ◽  
G Michael Felker ◽  
◽  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Risk Stratification ◽  
Cardiac Fibrosis ◽  
The Elderly ◽  
Preserved Ejection Fraction ◽  
Heart Failure Patients ◽  
Large Populations ◽  
Galectin 3

For many with heart failure, including the elderly and those with a preserved ejection fraction, both risk stratification and treatment are challenging. For these large populations and others there is increasing recognition of the role of cardiac fibrosis in the pathophysiology of heart failure. Galectin-3 is a novel biomarker of fibrosis and cardiac remodelling that represents an intriguing link between inflammation and fibrosis. In this article we review the biology of galectin-3, recent clinical research and its application in the management of heart failure patients.

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