scholarly journals Mechanism of Vascular Injury and Repair　― Importance of Lesion Morphology ―

2022 ◽  
Author(s):  
Setsu Nishino ◽  
Masashi Sakuma ◽  
Shichiro Abe ◽  
Shigeru Toyoda ◽  
Teruo Inoue
Keyword(s):  
Vascular Injury ◽  
Injury And Repair ◽  
Lesion Morphology

Abstract 66: Increased Circulating Inflammatory Endothelial Cells (IEC) in African-American vs. Caucasians with Essential Hypertension

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Alfonso Eirin ◽  
Sandra M Herrmann ◽  
Monika L Gloviczki ◽  
Xiangyang Zhu ◽  
Hui Tang ◽  
...  
Keyword(s):  
African American ◽  
Inflammatory Cytokines ◽  
Vascular Injury ◽  
Inflammatory Markers ◽  
Sodium Intake ◽  
Vena Cava ◽  
Renin Angiotensin System ◽  
Vascular Damage ◽  
Antihypertensive Medications ◽  
Injury And Repair

Introduction: Morbidity and mortality attributable to hypertension are higher in African American (AAEH) compared to Caucasian essential hypertensive (EH) patients, possibly related to a differential effect on vascular injury and repair. While circulating endothelial progenitor cells (EPC) preserve endothelial integrity IEC detach from sites of injury and represent markers of vascular damage. We hypothesized that plasma levels of IEC and inflammatory markers would be higher in AAEH compared to EH patients. METHODS: Inferior vena cava levels of CD34+/KDR+ (EPC) and VAP-1+ (IEC) cells were measured by FACS in EH and AAEH under fixed sodium intake (150 mEq/d) and blockade of the renin-angiotensin-system, and compared to systemic levels in normotensive control subjects (n=19 each). Systemic levels of inflammatory cytokines and EPC homing factors were measured by Luminex. Results: Blood pressure, serum creatinine, lipids, antihypertensive medications, and EPC levels did not differ between EH and AAEH patients. Circulating IEC were higher in AAEH, and inversely correlated with EPC levels (Figure). Systemic levels of inflammatory cytokines and EPC homing factors were higher in AAEH compared to EH patients (Table), and correlated directly with IEC. Conclusion: Despite preserved kidney function and controlled BP, circulating inflammatory markers were elevated in AAEH and correlated with increased IEC and decreased EPC levels. Increased release of cytokines and IEC in AAEH may impair EPC reparative capacity and predispose to hypertensive vascular injury. This process may aggravate vascular damage and accelerate hypertension-related morbidity/mortality rates in AAEH.

scholarly journals Analysis of pulmonary vascular injury and repair during Pseudomonas aeruginosa infection-induced pneumonia and acute respiratory distress syndrome

2019 ◽  
Vol 9 (1) ◽  
pp. 204589401982694 ◽  
Author(s):  
Ashley S. Lindsey ◽  
Lydia M. Sullivan ◽  
Nicole A. Housley ◽  
Anna Koloteva ◽  
Judy A. King ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Vascular Injury ◽  
Post Infection ◽  
Vascular Function ◽  
Distress Syndrome ◽  
Proliferative Phase ◽  
Injury And Repair

Herein we describe lung vascular injury and repair using a rodent model of Pseudomonas aeruginosa pneumonia-induced acute respiratory distress syndrome (ARDS) during: 1) the exudative phase (48-hour survivors) and 2) the reparative/fibro-proliferative phase (1-week survivors). Pneumonia was induced by intratracheal instillation of P. aeruginosa strain PA103, and lung morphology and pulmonary vascular function were determined subsequently. Pulmonary vascular function was assessed in mechanically ventilated animals in vivo (air dead space, PaO2, and lung mechanics) and lung permeability was determined in isolated perfused lungs ex vivo (vascular filtration coefficient and extravascular lung water). At 48 hours post infection, histological analyses demonstrated capillary endothelial disruption, diffuse alveolar damage, perivascular cuffs, and neutrophil influx into lung parenchyma. Infected animals displayed clinical hallmarks of ARDS, including increased vascular permeability, increased dead space, impaired gas exchange, and decreased lung compliance. Overall, the animal infection model recapitulated the morphological and functional changes typically observed in lungs from patients during the exudative phase of ARDS. At 1 week post infection, there was lung histological and pulmonary vascular functional evidence of repair when compared with 48 hours post infection; however, some parameters were still impaired when compared with uninfected controls. Importantly, lungs displayed increased fibrosis and cellular hyperplasia reminiscent of lungs from patients during the fibro-proliferative phase of ARDS. Control, sham inoculated animals showed normal lung histology and function. These data represent the first comprehensive assessment of lung pathophysiology during the exudative and reparative/fibro-proliferative phases of P. aeruginosa pneumonia-induced ARDS, and position this pre-clinical model for use in interventional studies aimed at advancing clinical care.

scholarly journals The role of inflammation in vascular injury and repair

2003 ◽  
Vol 1 (8) ◽  
pp. 1699-1709 ◽  
Author(s):  
C. Davis ◽  
J. Fischer ◽  
K. Ley ◽  
I. J. Sarembock
Keyword(s):  
Vascular Injury ◽  
Injury And Repair

Vascular injury and repair: a potential target for cell therapies

2015 ◽  
Vol 11 (1) ◽  
pp. 45-60 ◽  
Author(s):  
Andrew Mitchell ◽  
Takeshi Fujisawa ◽  
David Newby ◽  
Nicholas Mills ◽  
Nicholas L Cruden
Keyword(s):  
Vascular Injury ◽  
Cell Therapies ◽  
Potential Target ◽  
Injury And Repair

scholarly journals Revisiting Hormonal Control of Vascular Injury and Repair

2020 ◽  
Vol 127 (12) ◽  
pp. 1488-1490
Author(s):  
Daniel Pérez-Cremades ◽  
Henry S. Cheng ◽  
Mark W. Feinberg
Keyword(s):  
Vascular Injury ◽  
Hormonal Control ◽  
Injury And Repair

Flap Coverage Outcomes following Vascular Injury and Repair

2015 ◽  
Vol 135 (1) ◽  
pp. 301-308 ◽  
Author(s):  
Kevin Casey ◽  
Jennifer Sabino ◽  
Elliot Jessie ◽  
Barry D. Martin ◽  
Ian Valerio
Keyword(s):  
Vascular Injury ◽  
Flap Coverage ◽  
Injury And Repair

Inflammation, vascular injury and repair in rheumatoid arthritis

2009 ◽  
Vol 69 (Suppl 1) ◽  
pp. i57-i60 ◽  
Author(s):  
A J van Zonneveld ◽  
H C de Boer ◽  
E P van der Veer ◽  
T J Rabelink
Keyword(s):  
Rheumatoid Arthritis ◽  
Vascular Injury ◽  
Injury And Repair

Diagnostic workup and endovascular treatment of popliteal artery trauma

VASA ◽  
2019 ◽  
Vol 48 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Cheong J. Lee ◽  
Rory Loo ◽  
Max V. Wohlauer ◽  
Parag J. Patel
Keyword(s):  
Vascular Injury ◽  
Gold Standard ◽  
Imaging Techniques ◽  
Computed Tomographic Angiography ◽  
Vascular Trauma ◽  
Endovascular Techniques ◽  
Computed Tomographic ◽  
Arterial Injuries ◽  
Arterial Trauma ◽  
Peripheral Arterial

Abstract. Although management paradigms for certain arterial trauma, such as aortic injuries, have moved towards an endovascular approach, the application of endovascular techniques for the treatment of peripheral arterial injuries continues to be debated. In the realm of peripheral vascular trauma, popliteal arterial injuries remain a devastating condition with significant rates of limb loss. Expedient management is essential and surgical revascularization has been the gold standard. Initial clinical assessment of vascular injury is aided by readily available imaging techniques such as duplex ultrasonography and high resolution computed tomographic angiography. Conventional catheter based angiography, however, remain the gold standard in the determination of vascular injury. There are limited data examining the outcomes of endovascular techniques to address popliteal arterial injuries. In this review, we examine the imaging modalities and current approaches and data regarding endovascular techniques for the management popliteal arterial trauma.

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