scholarly journals Innovative drug discovery in Japan: past, present and future problems

1995 ◽  
Vol 106 (supplement) ◽  
pp. 20-22
Author(s):  
Ryuichi Kato
Keyword(s):  
Drug Discovery ◽  
Innovative Drug

Intra-Firm and Inter-Firm Learning in the Context of Start-Up Companies

2002 ◽  
Vol 3 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Helena Mäkinen
Keyword(s):  
Drug Discovery ◽  
High Technology ◽  
Business Environment ◽  
Innovative Drug ◽  
Specific Knowledge ◽  
Critical Feature ◽  
Start Up ◽  
New Knowledge ◽  
Interfirm Learning ◽  
National Business

Organizational learning has come to be seen as a critical feature of a firm's success. The concept captures the sense of a firm being involved in a process of continuous adaptation to a changing environment and drawing on organizational knowledge and competencies that can be brought to bear on any particular circumstance. Successful firms are good ‘learners’. Acquisition of new knowledge and competencies is especially important in high-technology companies. This paper asks what have been the main firm-specific knowledge and competencies of pharmaceutical start-up companies, and considers how the start-up companies have enlarged their knowledge and competencies through intra-firm and interfirm learning in a national business environment. The empirical issues are addressed in the context of four small innovative drug discovery companies in the Turku area of Finland. These are highly focused, specialized R&D companies that have been established as spin-off companies from larger firms or universities. They also saw the founding of a new cooperative pharmaceutical network as an essential response to the apparent resource gap.

scholarly journals New Perspectives on Innovative Drug Discovery: An Overview

2010 ◽  
Vol 13 (3) ◽  
pp. 450 ◽  
Author(s):  
Si Yuan Pan ◽  
Shan Pan ◽  
Zhi-Ling Yu ◽  
Dik-Lung Ma ◽  
Si-Bao Chen ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Wide Spectrum ◽  
Therapeutic Interventions ◽  
Biomedical Science ◽  
Innovative Drug ◽  
Alternative Medicines ◽  
Traditional Remedies ◽  
Available Information ◽  
Rate Of Success ◽  
Total Sales

Despite advances in technology, drug discovery is still a lengthy, expensive, difficult, and inefficient process, with a low rate of success. Today, advances in biomedical science have brought about great strides in therapeutic interventions for a wide spectrum of diseases. The advent of biochemical techniques and cutting-edge bio/chemical technologies has made available a plethora of practical approaches to drug screening and design. In 2010, the total sales of the global pharmaceutical market will reach 600 billion US dollars and expand to over 975 billion dollars by 2013. The aim of this review is to summarize available information on contemporary approaches and strategies in the discovery of novel therapeutic agents, especially from the complementary and alternative medicines, including natural products and traditional remedies such as Chinese herbal medicine.

Abstract A20: Innovative drug discovery for bladder cancer by miR-130 family seed-targeting locked nucleic acid

2016 ◽  
Author(s):  
Hiroshi Egawa ◽  
Kentaro Jingushi ◽  
Yuko Ueda ◽  
Kaori Kitae ◽  
Wataru Nakata ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Drug Discovery ◽  
Nucleic Acid ◽  
Locked Nucleic Acid ◽  
Innovative Drug

scholarly journals Endogenous galectins and the control of the host inflammatory response

2009 ◽  
Vol 201 (2) ◽  
pp. 169-184 ◽  
Author(s):  
Lucy V Norling ◽  
Mauro Perretti ◽  
Dianne Cooper
Keyword(s):  
Drug Discovery ◽  
Inflammatory Response ◽  
Inflammatory Diseases ◽  
Molecular Targets ◽  
Innovative Drug ◽  
New Era ◽  
Chronic Inflammatory Diseases ◽  
Endogenous Lectins ◽  
Anti Inflammatory ◽  
Host Inflammatory Response

A new era of research is being devoted to deciphering endogenous mediators and mechanisms that are in place to resolve the inflammatory response. Accruing evidence indicates that galectins fall into this category of immunoregulatory mediators signifying their use as prospective novel anti-inflammatory agents. The focus of this review is to depict the immunoregulatory bioactivities of three members of the galectin superfamily, Galectin (Gal)-1, Gal-3 and Gal-9. Emphasis is given to the studies investigating the properties of these endogenous lectins. Gal-1, Gal-3 and Gal-9 are emerging as pertinent players in the modulation of acute and chronic inflammatory diseases, autoimmunity and cancer, and thus being increasingly recognised as molecular targets for innovative drug discovery.

scholarly journals New Perspectives on Chinese Herbal Medicine (Zhong-Yao) Research and Development

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Si-Yuan Pan ◽  
Si-Bao Chen ◽  
Hong-Guang Dong ◽  
Zhi-Ling Yu ◽  
Ji-Cui Dong ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Herbal Medicine ◽  
Research And Development ◽  
Chinese Herbal Medicine ◽  
Innovative Drug ◽  
Chinese Herbal ◽  
Traditional Remedies ◽  
Alternative Routes ◽  
Clinical Conditions ◽  
Capital Intensive

Synthetic chemical drugs, while being efficacious in the clinical management of many diseases, are often associated with undesirable side effects in patients. It is now clear that the need of therapeutic intervention in many clinical conditions cannot be satisfactorily met by synthetic chemical drugs. Since the research and development of new chemical drugs remain time-consuming, capital-intensive and risky, much effort has been put in the search for alternative routes for drug discovery in China. This narrative review illustrates various approaches to the research and drug discovery in Chinese herbal medicine. Although this article focuses on Chinese traditional drugs, it is also conducive to the development of other traditional remedies and innovative drug discovery.

34 Innovative drug discovery for bladder cancer: Targeting miR – 130 family molecules using locked nucleic acids

2015 ◽  
Vol 14 (2) ◽  
pp. e34-e34a
Author(s):  
M. Uemura ◽  
H. Egawa ◽  
W. Nakata ◽  
K. Fujita ◽  
K. Jingushi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Drug Discovery ◽  
Nucleic Acids ◽  
Cancer Targeting ◽  
Innovative Drug ◽  
Locked Nucleic Acids
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