scholarly journals Callitrichid IgM-nephropathy-an old age-related disease?

1995 ◽  
Vol 29 (1) ◽  
pp. 54-58 ◽  
Author(s):  
M. Brack
2021 ◽  
Vol 8 (2) ◽  
pp. 42-45
Author(s):  
Zehra Zaidi ◽  
Shehla Nazir ◽  
Abdul Nasir ◽  
Minhaj Ahmad

The average human life expectancy has increased in recent times, so there is more focus on aging, age-related disease, and geriatric care in society. Older malnourished adults are more likely to have poorer health outcomes, longer hospital stays, and increased mortality, so there is a need to provide a nutritious and healthy diet to the old age population.Recent studies have shown that some medicinal herbs are effective in the intervention or prevention of aging-associated neurological disorders. Unani System of Medicine is one of the old traditional medicines in the world providing health care to humanity for centuries successively through natural safe, effective, and economic herbal medicine.Diets recommended for the old age population have been highlighted in this article with special emphasis on the traditional diets mentioned in the USM for geriatric care. There is a need to explore USM for better care of old age population and to find out an effective, safe, and economic treatment for old age diseases like Parkinson's disease and Alzheimer's disease, etc.


Immuno ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 231-239
Author(s):  
Alexander I. Mosa

Discrepancies in lifespan and healthy-life span are predisposing populations to an increasing burden of age-related disease. Accumulating evidence implicates aging of the immune system, termed immunosenescence, in the pathogenesis of multiple age-related diseases. Moreover, immune dysregulation in the elderly increases vulnerability to infection and dampens pathogen-specific immune responses following vaccination. The health challenges manifesting from these age related deficits have been dramatically exemplified by the current SARS-CoV-2 pandemic. Approaches to either attenuate or reverse functional markers of immunosenescence are therefore urgently needed. Recent evidence suggests systemic immunomodulation via non-specific vaccination with live-attenuated vaccines may be a promising avenue to at least reduce aged population vulnerability to viral infection. This short review describes current understanding of immunosenescence, the historical and mechanistic basis of vaccine-mediated immunomodulation, and the outstanding questions and challenges required for broad adoption.


Gerontology ◽  
2016 ◽  
Vol 63 (2) ◽  
pp. 103-117 ◽  
Author(s):  
Cia-Hin Lau ◽  
Yousin Suh

The recent advent of genome and epigenome editing technologies has provided a new paradigm in which the landscape of the human genome and epigenome can be precisely manipulated in their native context. Genome and epigenome editing technologies can be applied to many aspects of aging research and offer the potential to develop novel therapeutics against age-related diseases. Here, we discuss the latest technological advances in the CRISPR-based genome and epigenome editing toolbox, and provide insight into how these synthetic biology tools could facilitate aging research by establishing in vitro cell and in vivo animal models to dissect genetic and epigenetic mechanisms underlying aging and age-related diseases. We discuss recent developments in the field with the aims to precisely modulate gene expression and dynamic epigenetic landscapes in a spatial and temporal manner in cellular and animal models, by complementing the CRISPR-based editing capability with conditional genetic manipulation tools including chemically inducible expression systems, optogenetics, logic gate genetic circuits, tissue-specific promoters, and the serotype-specific adeno-associated virus. We also discuss how the combined use of genome and epigenome editing tools permits investigators to uncover novel molecular pathways involved in the pathophysiology and etiology conferred by risk variants associated with aging and aging-related disease. A better understanding of the genetic and epigenetic regulatory mechanisms underlying human aging and age-related disease will significantly contribute to the developments of new therapeutic interventions for extending health span and life span, ultimately improving the quality of life in the elderly populations.


2015 ◽  
Vol 21 (12) ◽  
pp. 1395-1399 ◽  
Author(s):  
Mary Armanios ◽  
Rafael de Cabo ◽  
Joan Mannick ◽  
Linda Partridge ◽  
Jan van Deursen ◽  
...  

2010 ◽  
Vol 6 ◽  
pp. S40-S40
Author(s):  
Olof E. Lindberg ◽  
Carl-Henrik Ehrenkrona ◽  
Linnea Engström ◽  
Leif A. Svensson ◽  
Eva Öhrndahl ◽  
...  

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