Imaging after percutaneous thermal and non-thermal ablation of hepatic tumour: normal appearances, progression and complications

2021 ◽  
pp. 20201327
Author(s):  
Germain Bréhier ◽  
Louis Besnier ◽  
Anaïs Delagnes ◽  
Frédéric Oberti ◽  
Jérôme Lebigot ◽  
...  

The increasing number of liver tumours treated by percutaneous ablation leads all radiologists to be confronted with the difficult interpretation of post-ablation imaging. Radiofrequency and microwave techniques are most commonly used. Recently, irreversible electroporation treatments that do not induce coagulation necrosis but cellular apoptose and respect the collagen architecture of bile ducts and vessels have been introduced and lead to specific post-ablation features and evolution. Ablations cause ‘normal’ changes in ablation and periablation zones. It is necessary to know these post-ablation features to avoid the misinterpretation of recurrence or complication that would lead to unnecessary treatments. Another challenge for the radiologist is to detect as early as possible the residual unablated tumour or the disease progression (local progression and tumour seeding) that will require a new treatment. Finally, the complications, frequent or rarer, should be recognised to be managed adequately. The purpose of this article is therefore to describe the large spectrum of normal and pathological aspects related to the treatment of hepatic tumour by percutaneous thermal ablation and irreversible electroporation ablation.

2018 ◽  
Vol 69 (1) ◽  
pp. 51-62 ◽  
Author(s):  
Robbert S. Puijk ◽  
Alette H. Ruarus ◽  
Hester J. Scheffer ◽  
Laurien G.P.H. Vroomen ◽  
Aukje A.J.M. van Tilborg ◽  
...  

Liver tumour ablation nowadays represents a routine treatment option for patients with primary and secondary liver tumours. Radiofrequency ablation and microwave ablation are the most widely adopted methods, although novel techniques, such as irreversible electroporation, are quickly working their way up. The percutaneous approach is rapidly gaining popularity because of its minimally invasive character, low complication rate, good efficacy rate, and repeatability. However, matched to partial hepatectomy and open ablations, the issue of ablation site recurrences remains unresolved and necessitates further improvement. For percutaneous liver tumour ablation, several real-time imaging modalities are available to improve tumour visibility, detect surrounding critical structures, guide applicators, monitor treatment effect, and, if necessary, adapt or repeat energy delivery. Known predictors for success are tumour size, location, lesion conspicuity, tumour-free margin, and operator experience. The implementation of reliable endpoints to assess treatment efficacy allows for completion-procedures, either within the same session or within a couple of weeks after the procedure. Although the effect on overall survival may be trivial, (local) progression-free survival will indisputably improve with the implementation of reliable endpoints. This article reviews the available needle navigation techniques, evaluates potential treatment endpoints, and proposes an algorithm for quality control after the procedure.


2020 ◽  
Author(s):  
Linyu Zhou ◽  
Shanyu Yin ◽  
Weilu Chai ◽  
Qiyu Zhao ◽  
Guo Tian ◽  
...  

Abstract Background: To describe the contrast-enhanced ultrasound imaging findings of liver tumours after percutaneous ablation by irreversible electroporation (IRE). Methods: A prospective study of 21 malignant liver tumours (19 primary hepatic tumours and 2 hepatic metastases) treated by IRE ablation was performed. The ablation zones were evaluated by two examiners in a consensus reading performed immediately, 1 day, and 1 month after IRE ablation. The gold standard method with which the effectiveness of the treatment at 1 month is compared, is MRI. Results: Immediately after IRE ablation and up to 1 month later, the ablation zones gradually changed from hypo-echogenicity to hyper-echogenicity on conventional ultrasound, and becomes non-enhancement on contrast-enhanced ultrasound (CEUS). There was substantial agreement (κ = 0.77, p < 0.05) between the results obtained with CEUS and those obtained with MRI 1 month after IRE ablation. Conclusions: We conclude that CEUS could be an effective tool for assessing post-irreversible electroporation ablation changes after 1 month. CEUS enables the depiction of tumour vascularity in real time and provides an easy, repeatable way.


2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Linyu Zhou ◽  
Shanyu Yin ◽  
Weilu Chai ◽  
Qiyu Zhao ◽  
Guo Tian ◽  
...  

Abstract Background Familiarity with post-IRE imaging interpretation is of considerable importance in determining ablation success and detecting recurrence. CEUS can be used to assess the tumour response and characteristics of the ablation zone. It is of clinical interest to describe the ultrasonographic findings of liver tumours after irreversible electroporation (IRE) percutaneous ablation. Methods A prospective study of 24 cases of malignant liver tumours (22 cases of primary liver tumours and 2 cases of liver metastases) treated by IRE ablation was conducted. Two inspectors evaluated the ablation zone in a consensus reading performed immediately, 1 day, and 1 month after IRE ablation. The gold standard method, magnetic resonance imaging (MRI), was used to evaluate the effectiveness of the treatment at 1 month. Results Immediately after IRE ablation and up to 1 month later, the ablation zones gradually changed from hypo-echogenicity to hyper-echogenicity on conventional ultrasound and showed non-enhancement on contrast-enhanced ultrasound (CEUS). One month after IRE ablation, CEUS and MRI results were highly consistent (κ = 0.78, p < 0.05). Conclusions We conclude that CEUS may be an effective tool for assessing post-IRE ablation changes after 1 month. CEUS enables the depiction of tumour vascularity in real time and serves as an easy, repeatable method.


2019 ◽  
Vol 53 (1) ◽  
pp. 116-122 ◽  
Author(s):  
Niklas Verloh ◽  
Isabel Jensch ◽  
Lukas Lürken ◽  
Michael Haimerl ◽  
Marco Dollinger ◽  
...  

Abstract Background To compare the frequency of adverse events of thermal microwave (MWA) and radiofrequency ablation (RFA) with non-thermal irreversible electroporation (IRE) in percutaneous ablation of hepatocellular carcinoma (HCC). Patients and methods We retrospectively analyzed 117 MWA/RFA and 47 IRE procedures (one tumor treated per procedure; 144 men and 20 women; median age, 66 years) regarding adverse events, duration of hospital and intensive care unit (ICU) stays and occurrence of a post-ablation syndrome. Complications were classified according to the Clavien & Dindo classification system. Results 70.1% of the RFA/MWA and 63.8% of the IRE procedures were performed without complications. Grade I and II complications (any deviation from the normal postinterventional course, e.g., analgesics) occurred in 26.5% (31/117) of MWA/RFA and 34.0% (16/47) of IRE procedures. Grade III and IV (major) complications occurred in 2.6% (3/117) of MWA/RFA and 2.1% (1/47) of IRE procedures. There was no significant difference in the frequency of complications (p = 0.864), duration of hospital and ICU stay and the occurrence of a post-ablation syndrome between the two groups. Conclusions Our results suggest that thermal (MWA and RFA) and non-thermal IRE ablation of malignant liver tumors have comparable complication rates despite the higher number of punctures and the lack of track cauterization in IRE.


2014 ◽  
Vol 35 (10) ◽  
pp. 1045
Author(s):  
Jian-quan ZHANG ◽  
Jian-guo SHENG ◽  
Zong-ping DIAO ◽  
Lu-lu ZHAO ◽  
Hang ZHANG

2018 ◽  
Vol 42 (3) ◽  
pp. 344-357 ◽  
Author(s):  
Julien Garnon ◽  
Roberto Luigi Cazzato ◽  
Jean Caudrelier ◽  
Maud Nouri-Neuville ◽  
Pramod Rao ◽  
...  

2017 ◽  
Vol 98 (9) ◽  
pp. 609-617 ◽  
Author(s):  
L.G.P.H. Vroomen ◽  
E.N. Petre ◽  
F.H. Cornelis ◽  
S.B. Solomon ◽  
G. Srimathveeravalli

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