scholarly journals Irreversible Electroporation in Patients With Liver Tumours: Treated-area Patterns With Contrast-enhanced Ultrasound

2020 ◽  
Author(s):  
Linyu Zhou ◽  
Shanyu Yin ◽  
Weilu Chai ◽  
Qiyu Zhao ◽  
Guo Tian ◽  
...  

Abstract Background: To describe the contrast-enhanced ultrasound imaging findings of liver tumours after percutaneous ablation by irreversible electroporation (IRE). Methods: A prospective study of 21 malignant liver tumours (19 primary hepatic tumours and 2 hepatic metastases) treated by IRE ablation was performed. The ablation zones were evaluated by two examiners in a consensus reading performed immediately, 1 day, and 1 month after IRE ablation. The gold standard method with which the effectiveness of the treatment at 1 month is compared, is MRI. Results: Immediately after IRE ablation and up to 1 month later, the ablation zones gradually changed from hypo-echogenicity to hyper-echogenicity on conventional ultrasound, and becomes non-enhancement on contrast-enhanced ultrasound (CEUS). There was substantial agreement (κ = 0.77, p < 0.05) between the results obtained with CEUS and those obtained with MRI 1 month after IRE ablation. Conclusions: We conclude that CEUS could be an effective tool for assessing post-irreversible electroporation ablation changes after 1 month. CEUS enables the depiction of tumour vascularity in real time and provides an easy, repeatable way.

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Linyu Zhou ◽  
Shanyu Yin ◽  
Weilu Chai ◽  
Qiyu Zhao ◽  
Guo Tian ◽  
...  

Abstract Background Familiarity with post-IRE imaging interpretation is of considerable importance in determining ablation success and detecting recurrence. CEUS can be used to assess the tumour response and characteristics of the ablation zone. It is of clinical interest to describe the ultrasonographic findings of liver tumours after irreversible electroporation (IRE) percutaneous ablation. Methods A prospective study of 24 cases of malignant liver tumours (22 cases of primary liver tumours and 2 cases of liver metastases) treated by IRE ablation was conducted. Two inspectors evaluated the ablation zone in a consensus reading performed immediately, 1 day, and 1 month after IRE ablation. The gold standard method, magnetic resonance imaging (MRI), was used to evaluate the effectiveness of the treatment at 1 month. Results Immediately after IRE ablation and up to 1 month later, the ablation zones gradually changed from hypo-echogenicity to hyper-echogenicity on conventional ultrasound and showed non-enhancement on contrast-enhanced ultrasound (CEUS). One month after IRE ablation, CEUS and MRI results were highly consistent (κ = 0.78, p < 0.05). Conclusions We conclude that CEUS may be an effective tool for assessing post-IRE ablation changes after 1 month. CEUS enables the depiction of tumour vascularity in real time and serves as an easy, repeatable method.


2020 ◽  
Vol 06 (03) ◽  
pp. E76-E86
Author(s):  
Diletta Cozzi ◽  
Simone Agostini ◽  
Elena Bertelli ◽  
Michele Galluzzo ◽  
Emanuela Papa ◽  
...  

AbstractConventional ultrasound imaging (US) is the first-line investigation in acute non-traumatic abdominal emergencies, but sometimes it needs further examinations, such as computed tomography (CT), to reach a certain diagnosis. Contrast-enhanced ultrasound (CEUS), through injection of contrast medium, may provide the radiologist with additional information that could not be investigated with baseline US. It could help reach a diagnosis and rapidly determine the proper therapy in an emergency setting. The purpose of this review is to explain and illustrate the various possibilities and limitations of CEUS in acute non-traumatic abdominal diseases, in particular acute inflammation, parenchymal infarcts, and hemorrhages.


2017 ◽  
Vol 43 (4) ◽  
pp. 819-847 ◽  
Author(s):  
Isabelle Durot ◽  
Stephanie R. Wilson ◽  
Jürgen K. Willmann

2019 ◽  
Vol 16 (6) ◽  
pp. 37-46
Author(s):  
Adina Cociorvei

AbstractAbdominal contrast enhanced ultrasound (CEUS) is a relatively new investigation method that combines conventional ultrasound with a small amount of intravenous contrast through a peripheral vein (usually the cubital vein). The contrast is made by very small gas microbubbles floating in a phospholipid suspension. The size of microbubbles are between 1-10 micrometers, being to large to go out of the vessels, but sufficiently small to stay into the capillaries, and this is the reason for they can be used as vascular tracers. So, it is possible to obtain images with microvessels inside of different organs in different vascular phases (arterial, portal, venous), images that are similar with the one obtained in CECT and CEMRI.The intravenous contrast used in CEUS eliminates trough the lungs, during expiration. These is the reason why the most important contraindication for using iv contrast is severe respiratory failure. Also, it is important that intravenous contrast is not allergenic, the percentage of allergic reaction being extremly small (0,001%).The most important advantages of CEUS are:• It can be safely used for the pacients that are allergic to intravenous contrast used in CECT and CEMRI;• It can be used in pacients with chronic kidney disease;Abdominal contrast enhanced ultrasound is used in day-to-day practice mainly for evaluation of hepatic lesions, but also for pancreatic, kidney, testis pathology, as well as for inflammatory bowel diseases.


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