scholarly journals A case-control evaluation of pulmonary and extrapulmonary findings of incidental asymptomatic COVID-19 infection on FDG PET-CT

2021 ◽  
Author(s):  
Manil Subesinghe ◽  
Shaheel Bhuva ◽  
Joel T Dunn ◽  
Alexander Hammers ◽  
Gary J Cook ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Case Control ◽  
Ground Glass ◽  
Suspected Case ◽  
Rt Pcr ◽  
Ground Glass Opacification ◽  
Pet Ct ◽  
Control Evaluation ◽  
Fdg Pet Ct ◽  
Pcr Test

Objectives: To describe the findings of incidental asymptomatic COVID-19 infection on FDG PET-CT using a case-control design. Methods: Incidental pulmonary findings suspicious of asymptomatic COVID-19 infection on FDG PET-CT were classified as a confirmed (positive RT-PCR test) or suspected case (no/negative RT-PCR test). Control cases were identified using a 4:1 control:case ratio. Pulmonary findings were re-categorised by two reporters using the BSTI classification. SUV metrics in ground glass opacification (GGO)/consolidation (where present), background lung, intrathoracic nodes, liver, spleen, and bone marrow were measured. Results: 7/9 confirmed and 11/15 suspected cases (COVID-19 group) were re-categorised as BSTI 1 (classic/probable COVID-19) or BSTI 2 (indeterminate COVID-19); 0/96 control cases were categorised as BSTI 1. Agreement between two reporters using the BSTI classification was almost perfect (weighted κ = 0.94). SUVmax GGO/consolidation (5.1 vs 2.2; p < 0.0001) and target-to-background ratio, normalised to liver SUVmean(2.4 vs 1.0; p < 0.0001) were higher in the BSTI 1 & two group vs BSTI 3 (non-COVID-19) cases. SUVmax GGO/consolidation discriminated between the BSTI 1 & two group and BSTI 3 (non-COVID-19) cases with high accuracy (AUC = 0.93). SUV metrics were higher (p < 0.05) in the COVID-19 group vs control cases in the lungs, intrathoracic nodes, and spleen. Conclusion: Asymptomatic COVID-19 infection on FDG PET-CT is characterised by bilateral areas of FDG avid (intensity > x2 liver SUVmean) GGO/consolidation and can be identified with high interobserver agreement using the BSTI classification. There is generalised background inflammation within the lungs, intrathoracic nodes, and spleen. Advances in knowledge: Incidental asymptomatic COVID-19 infection on FDG PET-CT, characterised by bilateral areas of ground glass opacification and consolidation, can be identified with high reproducibility using the BSTI classification. The intensity of associated FDG uptake (>x2 liver SUVmean) provides high discriminative ability in differentiating such cases from pulmonary findings in a non-COVID-19 pattern. Asymptomatic COVID-19 infection causes a generalised background inflammation within the mid-lower zones of the lungs, hilar and central mediastinal nodal stations, and spleen on FDG PET-CT. A case-control evaluation of pulmonary and extrapulmonary findings of incidental asymptomatic COVID-19 infection on FDG PET-CT.

scholarly journals Association Between 18F-FDG PET/CT-Based SUV Index and Malignant Status of Persistent Ground-Glass Nodules

2021 ◽  
Vol 11 ◽  
Author(s):  
Rong Niu ◽  
Yuetao Wang ◽  
Xiaoliang Shao ◽  
Zhenxing Jiang ◽  
Jianfeng Wang ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Correlation Factor ◽  
Ground Glass ◽  
Imaging Data ◽  
Malignancy Risk ◽  
Pet Ct ◽  
Average Probability ◽  
Fdg Pet Ct ◽  
Benign Group ◽  
Ground Glass Nodules

To explore the association between 18F-FDG PET/CT-based SUV index and malignant risk of persistent ground-glass nodules (GGNs). We retrospectively analyzed a total of 166 patients with GGN who underwent PET/CT examination from January 2012 to October 2019. There were 113 women and 53 men, with an average age of 60.8 ± 9.1 years old. A total of 192 GGNs were resected and confirmed by pathology, including 22 in benign group and 170 in adenocarcinoma group. They were divided into three groups according to SUV index tertiles: Tertile 1 (0.14–0.54), Tertile 2 (0.55–1.17), and Tertile 3 (1.19–6.78), with 64 GGNs in each group. The clinical and imaging data of all patients were collected and analyzed. After adjusting for the potential confounding factors, we found that the malignancy risk of GGN significantly decreased as the SUV index increased (OR, 0.245; 95%CI, 0.119–0.504; P &lt;0.001), the average probability of malignant GGN was 89.1% (95% CI, 53.1–98.3%), 80.5% (95% CI, 36.7–96.7%), and 34.3% (95%CI, 9.5–72.2%) for Tertile 1 to Tertile 3. And the increasing trend of SUV index was significantly correlated with the reduction of malignant risk (OR, 0.099; 95%CI, 0.025–0.394; P = 0.001), especially between Tertile 3 versus Tertile 1 (OR, 0.064; 95%CI, 0.012–0.356; P = 0.002). Curve fitting showed that the SUV index was linearly and negatively correlated with the malignant risk of GGN. SUV index is an independent correlation factor for malignancy risk of GGN, the higher the SUV index, the lower the probability of GGN malignancy.

Differentiation between malignancy and inflammation in pulmonary ground-glass nodules: The feasibility of integrated 18F-FDG PET/CT

Lung Cancer ◽  
2009 ◽  
Vol 65 (2) ◽  
pp. 180-186 ◽  
Author(s):  
Eun Ju Chun ◽  
Hyun Ju Lee ◽  
Won Jun Kang ◽  
Kwang Gi Kim ◽  
Jin Mo Goo ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Ground Glass ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Ground Glass Nodules

Towards an optimal semiquantitative approach in giant cell arteritis: an 18F-FDG PET/CT case-control study

2013 ◽  
Vol 41 (1) ◽  
pp. 155-166 ◽  
Author(s):  
Florent L. Besson ◽  
Hubert de Boysson ◽  
Jean-Jacques Parienti ◽  
Gérard Bouvard ◽  
Boris Bienvenu ◽  
...  
Keyword(s):  
Giant Cell Arteritis ◽  
Giant Cell ◽  
Fdg Pet ◽  
Case Control Study ◽  
Case Control ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Control Study

scholarly journals Rapidly growing pulmonary ground-glass nodule caused by metastatic melanoma lacking uptake on 18F-FDG PET-CT

2018 ◽  
Vol 44 (2) ◽  
pp. 171-172 ◽  
Author(s):  
Giorgia Dalpiaz ◽  
Sofia Asioli ◽  
Stefano Fanti ◽  
Gaetano Rea ◽  
Edson Marchiori
Keyword(s):  
Metastatic Melanoma ◽  
Fdg Pet ◽  
Ground Glass ◽  
Pet Ct ◽  
Ground Glass Nodule ◽  
18F Fdg ◽  
Fdg Pet Ct

Incidental 18F-FDG PET/CT finding of COVID-1 pneumonia in asymptomatic patient diagnosed with lung abscess metastasis

2020 ◽  
Author(s):  
Antoni Mestre-Fusco ◽  
Mònica Velasco-Nuño ◽  
Montserrat Negre-Busó ◽  
Núria Ferran ◽  
Sergi Juanpere ◽  
...  
Keyword(s):  
Ct Scan ◽  
Fdg Pet ◽  
Lung Abscess ◽  
Low Grade ◽  
Rt Pcr ◽  
Severe Respiratory Distress ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Pet Ct Scan

Abstract A 66-year-old male patient, with chronic respiratory disease and right colon resection in March 2017 for colon low-grade adenocarcinoma was assessed for recurrence suggested by elevated levels of tumor marker and no evidence of oncological disease by CT scan. 18F-FDG PET/CT showed bilateral multiple peripheral FDG-avid foci that matched with a peripheral predominant ground-glass opacities (GGOs) observed in lower lobes and multiple FDG-positive enlarged lymph nodes were also identified in the mediastinum. Patient was hospitalized in March 14th 2020, one day after PET/CT scan, with cough, wheezing and fever, and was treated with anti-inflammatory drugs. A first SARS-CoV-2 RT-PCR in March 15th resulted as negative and patient was treated with antibiotic therapy lead to an improvement of respiratory symptoms. PET/CT scan was interpreted as a pneumonia foci. A deteriorating patient condition was observed, with respiratory symptomatology progression, fatigue and D-Dimer elevation and a new RT-PCR resulted positive. A week after PET/CT scan, hospitalization in intensive care unit was necessary for rapidly disease progression and severe respiratory distress syndrome and patient died four days later.

scholarly journals Long COVID hallmarks on [18F]FDG-PET/CT: a case-control study

2021 ◽  
Author(s):  
Martina Sollini ◽  
Silvia Morbelli ◽  
Michele Ciccarelli ◽  
Maurizio Cecconi ◽  
Alessio Aghemo ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Case Control Study ◽  
Case Control ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Control Study

scholarly journals COVID-19 and Aspiration Pneumonia: Similar Pulmonary Findings with Different Diagnoses—a Pitfall in [18F]FDG PET/CT

2021 ◽  
Author(s):  
Virginia Liberini ◽  
Serena Grimaldi ◽  
Martin W. Huellner ◽  
Francesca Giunta ◽  
Costanza Bachi ◽  
...  
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Aspiration Pneumonia ◽  
Fdg Pet ◽  
Ground Glass Opacity ◽  
Differential Diagnoses ◽  
Ground Glass ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

AbstractSince December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a worldwide pandemic. Especially in the centers most affected by the pandemic, symptoms (such as fever, cough, myalgia, or fatigue) and/or radiological signs (such as ground-glass opacity) typically related to COVID-19 often diverted clinicians’ attention from other diseases. Despite the urgency to recognize and cure SARS-CoV-2 infection, a plethora of differential diagnoses must be considered, and other diseases must be equally and promptly treated, as described in this case report.

Shorter-time dual-phase FDG PET/CT in characterizing solid or ground-glass nodules based on surgical results

2012 ◽  
Vol 36 (5) ◽  
pp. 509-514 ◽  
Author(s):  
Chen-Feng Chiu ◽  
Yu-Yi Lin ◽  
Wu-Huei Hsu ◽  
Chih-Yi Chen ◽  
Jun-Jun Yeh ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Ground Glass ◽  
Dual Phase ◽  
Surgical Results ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Ground Glass Nodules
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