Extranodal manifestations of lymphoma

Imaging ◽  
1999 ◽  
Vol 11 (4) ◽  
pp. 240-268 ◽  
Author(s):  
S J Vinnicombe ◽  
R H Reznek
Keyword(s):  
Extranodal Manifestations

scholarly journals Kikuchi-Fujimoto disease with multiple extra-nodal features - A clinical mimic

Reumatismo ◽  
2019 ◽  
Vol 71 (2) ◽  
pp. 105-107
Author(s):  
C.A. Mansoor ◽  
Z. Shemin
Keyword(s):  
Lymph Node ◽  
Lupus Erythematosus ◽  
Maculopapular Rash ◽  
Lymph Node Biopsy ◽  
High Grade Fever ◽  
Extranodal Involvement ◽  
Kikuchi’S Disease ◽  
Node Biopsy ◽  
Extranodal Manifestations ◽  
Kikuchi's Disease

Extranodal involvement in Kikuchi’s disease is uncommon. A 31-year-old previously healthy Indian woman was admitted with high grade fever, multiple joint pain and skin rash for 3 weeks. She had negative anti-nuclear antibodies and had features of Kikuchi’s disease on lymph node biopsy. She also had multiple extranodal manifestations including erythematous maculopapular rash, symmetric polyarthritis and hepatosplenomegaly. Kikuchi’s disease with extranodal involvement can clinically mimic diseases like hematological malignancies, connective tissue disorders and certain infections. A lymph node biopsy plays a crucial role in making an accurate diagnosis by excluding other diseases. A discussion on the importance of differentiating Kikuchi’s disease from systemic lupus erythematosus is included.

scholarly journals Parvovirus B19 detected in Rosai-Dorfman disease in nodal and extranodal manifestations

2006 ◽  
Vol 59 (12) ◽  
pp. 1320-1326 ◽  
Author(s):  
Y Mehraein ◽  
M Wagner ◽  
K Remberger ◽  
L Fuzesi ◽  
P Middel ◽  
...  
Keyword(s):  
Parvovirus B19 ◽  
Rosai Dorfman Disease ◽  
Extranodal Manifestations

scholarly journals Rosai-Dorfman disease presenting with extensive cutaneous manifestation - Case report

2013 ◽  
Vol 88 (2) ◽  
pp. 256-259 ◽  
Author(s):  
Paula Azevedo Borges Leal ◽  
Adrilena Lopes Adriano ◽  
Marcelle Parente Breckenfeld ◽  
Igor Santos Costa ◽  
Antônio Renê Diógenes de Sousa ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Cervical Lymphadenopathy ◽  
Cutaneous Manifestation ◽  
Common Site ◽  
Atypical Case ◽  
Inguinal Lymph Nodes ◽  
Rosai Dorfman Disease ◽  
Polyclonal Gammopathy ◽  
Extranodal Manifestations

Rosai-Dorfman disease is a benign, self-limited, idiopathic proliferative histiocytic disorder. It was first described in 1969 by Rosai and Dorfman. In its typical form the disease is characterized by extensive cervical lymphadenopathy associated with fever, polyclonal gammopathy and leukocytosis with neutrophilia. The skin is the most common site affected. Extranodal manifestations have been reported in 43% of cases. In this study, we report an atypical case of Rosai-Dorfman disease in a female with massive cutaneous manifestation on the thigh, associated with a minimal lymphadenopathy limited to the regional inguinal lymph nodes.

Sinus histiocytosis with massive lymphadenopathy in a Nigerian child

1982 ◽  
Vol 96 (1) ◽  
pp. 89-94 ◽  
Author(s):  
E. O. Adekeye ◽  
M. B. Edwards ◽  
G. F. Goubran
Keyword(s):  
Differential Diagnosis ◽  
Head And Neck ◽  
Sinus Histiocytosis ◽  
Unknown Aetiology ◽  
Massive Lymphadenopathy ◽  
Nigerian Child ◽  
Extranodal Manifestations ◽  
Cervical Lymphnodes

SummarySinus histiocytosis with massive lymphadenopathy is a rare, benign lympho-proliferative disorder of unknown aetiology that chiefly affects the cervical lymphnodes of children. Various extranodal manifestations are recognized, especially in the head and neck. A case is described in a Nigerian child that illustrates problems of differential diagnosis.

scholarly journals Rosai-Dorfman Disease: A Rare Cause of Cervical Lymphadenopathy

2014 ◽  
Vol 5 (3) ◽  
pp. 152-154
Author(s):  
Adharsh Anand ◽  
Kanchan Lanjewar ◽  
Vipin Ram Ekhar ◽  
Ritesh N Shelkar ◽  
Sachin Rane ◽  
...  
Keyword(s):  
Pathological Condition ◽  
Cervical Lymphadenopathy ◽  
Needle Aspiration ◽  
Benign Condition ◽  
Massive Lymphadenopathy ◽  
Rosai Dorfman Disease ◽  
Life Threatening ◽  
Children And Young Adults ◽  
Needle Aspiration Cytology ◽  
Extranodal Manifestations

ABSTRACT Rosai-Dorfman disease is also known as sinus histiocytosis with massive lymphadenopathy (SHML) is a rare clinico-pathological condition. It is a benign condition which causes significant cervical lymphadenopathy in children and young adults. The clinical presentation varies from isolated nodal involvement to significant extranodal manifestations. The clinical features are usually mild, but rarely life-threatening complications can occur in some individuals depending on the site of involvement. Here, we present two cases of Rosai-Dorfman disease, both diagnosed on fine needle aspiration cytology (FNAC) and histopathology and responded well to steroids. One of the patients had extranodal site involvement in the form of bilateral nasal mass which is very rare. How to cite this article Ekhar VR, Shelkar RN, Rane S, Anand A, Lanjewar K, Jain SKT. Rosai-Dorfman Disease: A Rare Cause of Cervical Lymphadenopathy. Int J Head Neck Surg 2014;5(3): 152-154.

scholarly journals Destombes–Rosai–Dorfman disease of the anterior abdominal wall: Extranodal sinus histiocytosis with massive lymphadenopathy

2021 ◽  
Vol 12 (1) ◽  
pp. 72-75
Author(s):  
Hubert Daisley Jr ◽  
Sailaja Golamari ◽  
Lilly Paul ◽  
Deandra Thomas-Romain ◽  
Dawn Meyers ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Abdominal Wall ◽  
Clinical Management ◽  
Anterior Abdominal Wall ◽  
Current Mode ◽  
Cervical Lymph Nodes ◽  
Massive Lymphadenopathy ◽  
Rosai Dorfman Disease ◽  
Extranodal Manifestations ◽  
Multiple Nodules

estombes–Rosai–Dorfman disease—often simply referred to, in the literature, as Rosai–Dorfman disease (RDD)—is a rare, nonmalignant disorder of histiocyte proliferation typically involving the cervical lymph nodes. A subset of patients with RDD, however, display extranodal manifestations highly variable in presentation, more challenging to diagnose, and less likely to spontaneously regress when compared to the nodal manifestations. This study describes the case of a young African male presenting himself with multiple nodules involving the anterior abdominal wall, who was found to have extranodal RDD. The current mode of diagnosis and the clinical management of RDD are reviewed.

Nasal manifestation of extranodal Rosai-Dorfman disease – diagnosis and management

1999 ◽  
Vol 113 (3) ◽  
pp. 275-280 ◽  
Author(s):  
Peter K. M. Ku ◽  
Michael C. F. Tong ◽  
C. Y. Leung ◽  
Martin W. Pak ◽  
C. Andrew van Hasselt
Keyword(s):  
Endoscopic Resection ◽  
Specific Treatment ◽  
Disease Diagnosis ◽  
Benign Disease ◽  
Sustained Remission ◽  
Rosai Dorfman Disease ◽  
Granulomatous Diseases ◽  
Extranodal Manifestations ◽  
Symptomatic Control

AbstractTwo cases of Rosai-Dorfman disease with polypoid nasal infiltration mimicking nasal tuberculosis and malignant lymphoma are reported. This rare benign disease was first described by Rosai and Dorfman in 1969 and is characterized by histiocytic proliferation. It is seldom considered in the differential diagnosis of granulomatous diseases due to its rarity and histological similarity to other diseases. Extranodal manifestations of this disease are uncommon. Although no specific treatment can guarantee a sustained remission of this disease, surgery for loco-regional lesions can result in long-term symptomatic control and restoration of function. Both patients underwent endoscopic resection of the nasal polypoid lesions and have subsequently been free of recurrence. Loco-regional infiltration of the nasal cavity by Rosai-Dorfman disease is effectively managed by endoscopic resection.

scholarly journals A Rare Case of Multiorgan Involvement of Rosai Dorfman Disease in an Elderly Female

1970 ◽  
Vol 52 (195) ◽  
pp. 955-957
Author(s):  
Rakesh Digambar Waghmare
Keyword(s):  
Cervical Lymph Node ◽  
Rare Case ◽  
East Asian ◽  
Sinus Histiocytosis ◽  
Asian Countries ◽  
Elderly Female ◽  
Massive Lymphadenopathy ◽  
Rosai Dorfman Disease ◽  
Lymph Node Enlargement ◽  
Extranodal Manifestations

Sinus histiocytosis with massive lymphadenopathy (SHML), Rosai-Dorfman Disease, is a rare histiocytic syndrome first described by Rosai and Dorfman, most frequently seen in children and young adults.The disease is more common in males and in individuals of African descent but rare in Asians. It is mainly characterized by painless bilateral cervical lymph node enlargement and is often associated with fever and leucocytosis. This case is being reported for its rarity in presentation in an elderly female with both generalized nodal as well as extranodal manifestations. Without the awareness about RDD, the diagnosis of RDD is unexpected especially in South East Asian Countries where certain lymphadenopathies such as tuberculosis, metastatic malignancies and lymphomas are common. Keywords: emperipolesis; rosai-dorfman disease; sinus histiocytosis with massive lymphadenopathy.

Mantle-cell lymphomas have more widespread disease and a slower response to chemotherapy compared with follicle-center lymphomas: results of a prospective comparative analysis of the German Low-Grade Lymphoma Study Group.

1998 ◽  
Vol 16 (5) ◽  
pp. 1922-1930 ◽  
Author(s):  
W Hiddemann ◽  
M Unterhalt ◽  
R Herrmann ◽  
H H Wöltjen ◽  
E D Kreuser ◽  
...  
Keyword(s):  
Residual Disease ◽  
Good Prognosis ◽  
Low Grade ◽  
Free Interval ◽  
Response To Chemotherapy ◽  
Mantle Cell ◽  
Long Term Prognosis ◽  
Lymphoma Study Group ◽  
Extranodal Manifestations

PURPOSE To compare mantle-cell lymphomas (MCLs) and follicle-center lymphomas (FCLs) for their features of clinical presentation, response to chemotherapy, and prognosis on the basis of a prospective randomized clinical trial. PATIENTS AND METHODS Patients with MCL and FCL who entered onto the prospective randomized comparison of cyclophosphamide, vincristine, and prednisone (COP) versus prednimustine and mitoxantrone (PmM) followed by a second randomization for interferon (IFN) maintenance versus observation only. RESULTS One hundred sixty-five of 234 patients had FCL and 45 of 234 patients had MCL. With FCL, both sexes were equally affected (men, 47%); patients with MCL were predominantly men (78%; P < .0004) and had a higher median age (64 v 53 years; P < .0001). Patients with MCL also had more widespread disease, reflected by the proportion of patients with two or greater extranodal manifestations (43% v 21%; P < .005) and nine or greater involved nodal areas (64% v 45%; nonsignificant [NS]). Response to chemotherapy was significantly lower in patients with MCL (complete remission [CR] + partial remission [PR], 69% v 88%; P < .05) and occurred at a slower pace. Patients with MCL also had a shorter event-free interval (median, 8 v 24 months; P < .0001) and overall survival (median, 28 v 77 months; P < .0001). In both subtypes, however, patients with less than two residual lymphoma manifestations in remission experienced a relatively good prognosis with an estimated 5-year survival of greater than 60% for MCL and greater than 75% for FCL. CONCLUSION MCL and FCL differ substantially in their features of presentation, response to chemotherapy, and long-term prognosis. The extent of residual disease after completion of chemotherapy discriminates patients with different prognosis and may be used for the stratification of postremission strategies.

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