scholarly journals Spectrum of preneoplastic and Neoplastic lesions of intestine in a tertiary care hospital of Karachi, Pakistan

2019 ◽  
Vol 36 (2) ◽  
Author(s):  
Asma Shabbir ◽  
Muhammad Asif Qureshi ◽  
Saadia Akram ◽  
Talat Mirza
Keyword(s):  
Adenomatous Polyp ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Premalignant Lesions ◽  
Reference Laboratory ◽  
Care Hospital ◽  
Neoplastic Lesions ◽  
Grade Ii ◽  
Malignant Lesions ◽  
Grade Iii

Objectives: To present 7 years data mentioning the spectrum of preneoplastic & neoplastic cases of intestine received at Dow Diagnostic Research and Reference Laboratory. Methods: All the cases of preneoplastic & neoplastic lesions of intestine received during 2009 – 2015 were reviewed. The data obtained were subjected to descriptive statistical analysis using SPSS version 22. Furthermore, the association of diagnosis was seen with various other variables including age, gender & site of the lesion. A p-value of < 0.05 was considered as significant. Results: The total samples were 486, out of which 33 cases were of premalignant and 453 were of malignant lesions. Out of total 33 cases of premalignant lesions of intestine, it consisted adenomatous polyp = 39.4% (n=13), dysplasia = 36.4% (n=12) and adenoma = 24.2% (n=8). From the total of 453 cases diagnosed as malignant lesions; adenocarcinoma as Grade-I were 14.2% (n=64), Grade-II were 7.6% (n=260) and Grade-III were 22% (n=99). Squamous cell carcinoma Grade-I were 0.4% (n=2), Grade-II 1.6% (n=7) and Grade-III 0.9% (n=4). 2.4% (n=11) cases were of metastatic adoncarcinoma, 0.9% (n=4) were diagnosed as neuroendocrine tumors and 0.4% (n=2) as lymphoma. A significant association was seen between site of the tumor and diagnosis, rectum was the commonest site for adenocarcinomas (p=0.001). Moderately differentiated adenocarcinoma was predominantly present in young age (p=0.001). Conclusion: Colorectal carcinoma is on rise in Pakistan, predominantly in young males, and rectum being the commonest site. In our study, all the lesions showed male predominance with adenomatous polyp as the commonest premalignant lesion & Grade-II adenocarcinoma the most common malignancy of intestine. doi: https://doi.org/10.12669/pjms.36.2.687 How to cite this:Shabbir A, Qureshi MA, Akram S, Mirza T. Spectrum of preneoplastic and Neoplastic lesions of intestine in a tertiary care hospital of Karachi, Pakistan. Pak J Med Sci. 2020;36(2):---------. doi: https://doi.org/10.12669/pjms.36.2.687 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Subglottic Stenosis in Children: Preliminary Experience from a Tertiary Care Hospital

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Manzoor Ahmad Latoo ◽  
Aleena Shafi Jallu
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Surgical Techniques ◽  
Subglottic Stenosis ◽  
Care Hospital ◽  
Reconstructive Procedure ◽  
Grade Ii ◽  
Laser Excision ◽  
Time Of Presentation ◽  
Grade Iii

Introduction. This retrospective study describes our experience in the evaluation and management of infants with subglottic stenosis. Materials and Methods. The study included 10 patients aged between 1 wk and 18 months with 6 cases having congenital subglottic stenosis and 4 cases having acquired subglottic stenosis. Results. 6 patients had grade I, 3 patients had grade II, and 1 patient had grade III subglottic stenosis. Tracheostomy was required in 4 patients at the time of presentation. 7 patients were treated successfully with Bougie dilation followed by topical application of mitomycin, whereas 1 patient who failed to serial dilation needed open reconstructive procedure. Laser excision of the anterior subglottic web was performed in one patient. Another patient with underlying cerebral palsy could not be operated upon and was managed with tracheostomy. Conclusion. Subglottic stenosis may be effectively man-aged with endoscopic surgical techniques, although the number of such sittings required varies with the type and severity of stenosis. Open surgical procedures need to be individualised as per the needs of the patient only after all the other endoscopic possibilities have been exhausted.

scholarly journals Nasomaxillary swellings: our experience at tertiary care hospital

2021 ◽  
Vol 7 (3) ◽  
pp. 469
Author(s):  
Mukesh Rawat ◽  
Archana Lall ◽  
Kavita Sachdeva
Keyword(s):  
Tertiary Care Hospital ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Final Diagnosis ◽  
Inverted Papilloma ◽  
Nasal Endoscopy ◽  
Common Symptom ◽  
Fungal Sinusitis ◽  
Care Hospital ◽  
Malignant Lesions

<p class="abstract"><strong>Background:  </strong>A wide spectrum of lesions may present as nasomaxillary swellings ranges from benign to malignant lesions including fungal sinusitis and fibro vascular lesions example: JNA (Juvenile nasopharyngeal angiofibroma) and Inverted papilloma. Many Pathologies ranging from benign to malignant tumors may mimic a simple Nasomaxillary mass. It is diagnostic challenge to determine pathology behind it. A detailed clinical evaluation with nasal endoscopy and relevant pre-operative investigations including radiological imaging and histopathological examination is essential to reach up to final diagnosis. The aim of the study was to do clinicopathological evaluation of patients presenting with nasomaxillary swelling and correlation of clinical, radiological and Histopathological findings.</p><p class="abstract"><strong>Methods: </strong>This was a prospective observational study on 50 nasomaxillary swelling patients who are presented in the Department of ENT and Head and Neck Surgery of N.S.C.B. MCH Jabalpur, a tertiary care Hospital, between March 2018 to August 2019. A detailed history taking and clinical examination with nasal endoscopy and relevant preoperative investigations including CECT Nose and PNS and histopathological examination was done in all patients.</p><p class="abstract"><strong>Results: </strong>50 Nasomaxillary swelling patients were selected for this study. 30 patients were male and 20 were females. Ages of patients were varied from 12 years to 72 years. 23 patients (46%) were malignant and 27 (54%) were benign. Histopathological examination results shows benign lesions like JNA (6 cases), fungal sinusitis (6 cases), dermoid cyst (1 case), inverted papilloma (3 cases), sebaceous cyst (1 case), jaw lesions (10 cases), (odontogenic like radicular/ infected cyst, dentigerous cyst, cystic ameloblastoma and non-odontogenic like fibrous dysplasia) and malignant lesions like SCC (squamous cell carcinoma) (12 cases), spindle cell sarcoma (2 cases), undifferentiated carcinoma (3 cases), adenocarcinoma (3 cases), adenoid cystic carcinoma (1 case), Invasive pleomorphic sarcoma (1 case) and malignant melanoma (1 case). SCC was most common lesion f/b JNA and fungal sinusitis. Well differentiated SCC was most common histological type (10 out of 12 cases of SCC). Most common symptom was nasal obstruction (66% cases) f/b epistaxis (52% cases) but epitasis was most common symptom among malignant and JNA cases. In 6 cases (3 JNA, 1 inverted papilloma, 1 malignancy and 1 radicular cyst) radiological diagnosis were not correlated with histological findings.</p><p class="abstract"><strong>Conclusions: </strong>Most our cases were malignant nasomaxillary lesions followed by fungal sinusitis and JNA. Most patients presented in advanced stage of disease so rapidly evaluation including nasal endoscopy should be done. CECT scan is essential to determine tumors extent and bony lesions. All patients should undergo hisotopatholigical examination. The final diagnosis should be made on the basis of clinical, radiological and histopathological findings.</p>

scholarly journals Neoplastic Lesions of Small and Large Intestine- A Prospective Study in Tertiary Care Hospital

2018 ◽  
Vol 5 (5) ◽  
pp. A429-433
Author(s):  
Venkata Kalyan Nunna ◽  
Prabhu M H ◽  
S. S. Inamdar ◽  
Mallikarjun Pattanashetti ◽  
Rachana L Y
Keyword(s):  
Prospective Study ◽  
Large Intestine ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Neoplastic Lesions ◽  
A Prospective Study ◽  
Small And Large Intestine

scholarly journals Epidemiological, clinical and histopathological features of meningiomas in a tertiary care hospital

2018 ◽  
Vol 5 (12) ◽  
pp. 5014
Author(s):  
Kanwar Sajid Ali ◽  
Malik Liaqat Ali Jalal ◽  
Sohaib Hassan ◽  
Muhammad Kashif
Keyword(s):  
Tertiary Care ◽  
Medical Institute ◽  
Care Hospital ◽  
Precision Data ◽  
Pathology Laboratory ◽  
Who Grade ◽  
Primary Tumors ◽  
Histopathological Features ◽  
Grade Ii ◽  
Grade Iii

Background: Meningiomas are the second most common primary tumors of the central nervous system. These tumors have an inherited tendency to progress and recur. These tumors are more common in females. The aim of this study was to observe the epidemiological, clinical and histopathological features of meningiomas in a tertiary care hospital.Methods: This observational study was conducted at the Pathology Department of the Postgraduate Medical Institute (PGMI) Lahore, Pakistan, from January 2013 to December 2013. The cases were collected from the Pathology Laboratory of the Lahore General Hospital, Lahore. This study was conducted on 50 cases of histologically diagnosed meningiomas. The sample size was calculated using 15% expected prevalence of meningiomas at 95% confidence interval and 10% level of precision. Data was entered and analyzed using SPSS version 17.Results: There were 22 (44%) male and 28 (56%) female patients in this study. The mean age of patients was 47.28±14.71 years with the median age 47 years. The minimum and maximum ages were 18 and 75 years and age range was 57 years. Out of 50 cases, fourty two cases were diagnosed as benign meningiomas (WHO Grade-I). Six cases were of atypical meningiomas (WHO grade II). Two cases were diagnosed as anaplastic meningiomas (WHO grade III).Conclusions: It can be concluded from the findings of present study that meningiomas are more common in females than males with grade I meningiomas outnumber the grade II and grade III meningiomas.

scholarly journals Histopathological spectrum of duodenal biopsies: Experience at a tertiary care hospital

2019 ◽  
Vol 2 (2) ◽  
pp. 58-61
Author(s):  
Zafar Ali ◽  
Ghazala Mudassir ◽  
Imran Nazir ◽  
Nadira Mamoon
Keyword(s):  
Celiac Disease ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Metastatic Adenocarcinoma ◽  
Signet Ring ◽  
Neoplastic Lesions ◽  
Crypt Hyperplasia ◽  
Duodenal Biopsies ◽  
Signet Ring Carcinoma

Objective: Endoscopic duodenal biopsies constitute a significant load of specimens in the histopathological section of a tertiary care hospital. Most of these diseases comprise non-neoplastic lesions causing significant morbidity. The purpose of this study was to see the frequency of these diseases in our patient population and to compare and analyze our results with similar other studies. Methods: In this retrospective study records of all duodenal biopsies reported from Feb 2017- Jan 2018 were retrieved. Both non neoplastic and neoplastic conditions along with biopsies with unremarkable findings were included. Various histological parameters like villous blunting, IEL count per 100 enterocytes, crypt hyperplasia, inflammation in lamina propria, and presence of microorganisms, any dysplasia or malignancy were studied. Data was statistically analyzed using SPSS v.23. Results: A total of 159 duodenal biopsies were included in the study. Normal duodenal morphology was noted in 85 (53.45%) cases while 74 (46.83%) cases revealed abnormal duodenal pathology. There were 46 (28.93%) cases consistent with celiac disease. Twenty eight (17.61%) cases were of other duodenal pathologies of which non-specific duodenitis was most common. There were 22 (13.83%) cases of duodenitis and 2 (1.26%) cases were of duodenal ulcer. One case (0.62%) each was seen of Brunner gland hyperplasia, adenocarcinoma, signet ring carcinoma and one case was of metastatic adenocarcinoma. Conclusion: In our study we found a significant percentage of 46.83% exhibiting abnormal duodenal pathology. Cases consistent with celiac disease were 28.93% while 13.83% of the cases had duodenitis. The percentage of malignant cases was minimal (1.88%).

scholarly journals Assessment of Utility of Fine Needle Aspiration Cytology in Patients of Peripheral Lymphadenopathy- Experience of A Tertiary Care Hospital

2021 ◽  
Vol 8 (8) ◽  
pp. A196-200
Author(s):  
Upender Sharma ◽  
Ajit Singh ◽  
Hemlata T Kamra ◽  
Atul Beniwal ◽  
Sonam Sharma
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Needle Aspiration ◽  
Care Hospital ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Neoplastic Lesions ◽  
Needle Aspiration Cytology

Background: Fine needle aspiration cytology (FNAC) is a quick, sensitive, safe, reliable and cost-effective outdoor procedure that has a lower risk of complications as compared to a surgical biopsy. This study was conducted to analyse the various cytomorphological patterns establishing the diagnosis on FNAC in peripheral lymphadenopathy patients along with their clinical presentation.Methods: This study included 300 patients of peripheral lymphadenopathy in a tertiary care hospital of north-central Haryana. FNAC was done under all aseptic conditions and various cytomorphological patterns were analysed.Result: On stratification of lymph node lesions, 240/300 cases (80%) were reported as non-neoplastic and 60/300 cases (20%) as neoplastic lesions. Among the non-neoplastic lesions, granulomatous pathology was the commonest lesion encountered in 137/240 cases (57.1%), followed by reactive lymphoid hyperplasia and suppurative lymphadenitis. Metastatic involvement of lymph node was the commonest pathological finding diagnosed in 52/60 of malignant neoplastic cases (86.66%). Overall, the cervical lymph nodes were most commonly involved in 68.66% patients, followed by other lymph nodes.Conclusion: Lymphadenopathy can have varied etiologies ranging from non-neoplastic to neoplastic conditions. FNAC as a first line investigative procedure in lymphadenopathy patients obviates the need for surgical excision and guides subsequent patient therapy and management. The cervical group of lymph nodes are most commonly involved in both non neoplastic as well as neoplastic lymph node lesions. In younger age group (<30 years) non neoplastic causes of lymphadenopathy are more common whereas in elderly the malignant neoplastic causes are more common. The secondary metastatic carcinoma is more common than primary lymphoma of the lymph nodes.  

scholarly journals Application of IAC Yokohama System For Reporting Breast Fine Needle Aspiration- A Retrospective Study

2021 ◽  
Vol 8 (8) ◽  
pp. A179-183
Author(s):  
Upender Sharma ◽  
Atul Beniwal ◽  
Sonam Sharma ◽  
Ajit Singh ◽  
Hemlata T Kamra
Keyword(s):  
Retrospective Study ◽  
Fine Needle Aspiration ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Care Hospital ◽  
North Central ◽  
Fine Needle ◽  
Malignant Lesions

Background: Breast cancer is one of the most common cancers worldwide in females and is an important cause of mortality and morbidity. FNAC is a safe, reliable, sensitive, specific, time saving and cost effective procedure useful in the diagnosis of carcinoma breast. It helps the surgeon in planning the treatment, and thereby reducing the delay in treatment. The primary aim of this study is to find out the spectrum of breast lesions on fine needle aspiration cytology based on IAC Yokohama system in a tertiary care hospital of north central Haryana.Methods: This is a retrospective study carried out in a tertiary care hospital of north-central Haryana and included 417 patients of palpable breast lumps presented in the Department of Pathology for FNAC during January 2018 to December 2019. FNAC was done under all aseptic conditions and various cytomorphological patterns were analysed according to the IAC Yokohama system for reporting breast fine needle aspirations.Result: Of the 417 cases included in the study, 328 cases were benign, 04 were atypical probably benign, 04 were suspicious for malignancy, 64 cases were malignant and 17 cases were inadequate for opinion. Fibroadenoma was found to be the most common breast lesion. Overall benign breast lesions are much more common than malignant lesions. Conclusion: FNAC is a useful tool to diagnose malignant lesions of the breast and help the surgeon in differentiating benign and malignant lesions. Early diagnosis aid in effective management of malignant lesions of the breast and thereby reducing the mortality in these patients.

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