scholarly journals Subglottic Stenosis in Children: Preliminary Experience from a Tertiary Care Hospital

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Manzoor Ahmad Latoo ◽  
Aleena Shafi Jallu
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Surgical Techniques ◽  
Subglottic Stenosis ◽  
Care Hospital ◽  
Reconstructive Procedure ◽  
Grade Ii ◽  
Laser Excision ◽  
Time Of Presentation ◽  
Grade Iii

Introduction. This retrospective study describes our experience in the evaluation and management of infants with subglottic stenosis. Materials and Methods. The study included 10 patients aged between 1 wk and 18 months with 6 cases having congenital subglottic stenosis and 4 cases having acquired subglottic stenosis. Results. 6 patients had grade I, 3 patients had grade II, and 1 patient had grade III subglottic stenosis. Tracheostomy was required in 4 patients at the time of presentation. 7 patients were treated successfully with Bougie dilation followed by topical application of mitomycin, whereas 1 patient who failed to serial dilation needed open reconstructive procedure. Laser excision of the anterior subglottic web was performed in one patient. Another patient with underlying cerebral palsy could not be operated upon and was managed with tracheostomy. Conclusion. Subglottic stenosis may be effectively man-aged with endoscopic surgical techniques, although the number of such sittings required varies with the type and severity of stenosis. Open surgical procedures need to be individualised as per the needs of the patient only after all the other endoscopic possibilities have been exhausted.

scholarly journals Spectrum of preneoplastic and Neoplastic lesions of intestine in a tertiary care hospital of Karachi, Pakistan

2019 ◽  
Vol 36 (2) ◽  
Author(s):  
Asma Shabbir ◽  
Muhammad Asif Qureshi ◽  
Saadia Akram ◽  
Talat Mirza
Keyword(s):  
Adenomatous Polyp ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Premalignant Lesions ◽  
Reference Laboratory ◽  
Care Hospital ◽  
Neoplastic Lesions ◽  
Grade Ii ◽  
Malignant Lesions ◽  
Grade Iii

Objectives: To present 7 years data mentioning the spectrum of preneoplastic & neoplastic cases of intestine received at Dow Diagnostic Research and Reference Laboratory. Methods: All the cases of preneoplastic & neoplastic lesions of intestine received during 2009 – 2015 were reviewed. The data obtained were subjected to descriptive statistical analysis using SPSS version 22. Furthermore, the association of diagnosis was seen with various other variables including age, gender & site of the lesion. A p-value of < 0.05 was considered as significant. Results: The total samples were 486, out of which 33 cases were of premalignant and 453 were of malignant lesions. Out of total 33 cases of premalignant lesions of intestine, it consisted adenomatous polyp = 39.4% (n=13), dysplasia = 36.4% (n=12) and adenoma = 24.2% (n=8). From the total of 453 cases diagnosed as malignant lesions; adenocarcinoma as Grade-I were 14.2% (n=64), Grade-II were 7.6% (n=260) and Grade-III were 22% (n=99). Squamous cell carcinoma Grade-I were 0.4% (n=2), Grade-II 1.6% (n=7) and Grade-III 0.9% (n=4). 2.4% (n=11) cases were of metastatic adoncarcinoma, 0.9% (n=4) were diagnosed as neuroendocrine tumors and 0.4% (n=2) as lymphoma. A significant association was seen between site of the tumor and diagnosis, rectum was the commonest site for adenocarcinomas (p=0.001). Moderately differentiated adenocarcinoma was predominantly present in young age (p=0.001). Conclusion: Colorectal carcinoma is on rise in Pakistan, predominantly in young males, and rectum being the commonest site. In our study, all the lesions showed male predominance with adenomatous polyp as the commonest premalignant lesion & Grade-II adenocarcinoma the most common malignancy of intestine. doi: https://doi.org/10.12669/pjms.36.2.687 How to cite this:Shabbir A, Qureshi MA, Akram S, Mirza T. Spectrum of preneoplastic and Neoplastic lesions of intestine in a tertiary care hospital of Karachi, Pakistan. Pak J Med Sci. 2020;36(2):---------. doi: https://doi.org/10.12669/pjms.36.2.687 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Epidemiological, clinical and histopathological features of meningiomas in a tertiary care hospital

2018 ◽  
Vol 5 (12) ◽  
pp. 5014
Author(s):  
Kanwar Sajid Ali ◽  
Malik Liaqat Ali Jalal ◽  
Sohaib Hassan ◽  
Muhammad Kashif
Keyword(s):  
Tertiary Care ◽  
Medical Institute ◽  
Care Hospital ◽  
Precision Data ◽  
Pathology Laboratory ◽  
Who Grade ◽  
Primary Tumors ◽  
Histopathological Features ◽  
Grade Ii ◽  
Grade Iii

Background: Meningiomas are the second most common primary tumors of the central nervous system. These tumors have an inherited tendency to progress and recur. These tumors are more common in females. The aim of this study was to observe the epidemiological, clinical and histopathological features of meningiomas in a tertiary care hospital.Methods: This observational study was conducted at the Pathology Department of the Postgraduate Medical Institute (PGMI) Lahore, Pakistan, from January 2013 to December 2013. The cases were collected from the Pathology Laboratory of the Lahore General Hospital, Lahore. This study was conducted on 50 cases of histologically diagnosed meningiomas. The sample size was calculated using 15% expected prevalence of meningiomas at 95% confidence interval and 10% level of precision. Data was entered and analyzed using SPSS version 17.Results: There were 22 (44%) male and 28 (56%) female patients in this study. The mean age of patients was 47.28±14.71 years with the median age 47 years. The minimum and maximum ages were 18 and 75 years and age range was 57 years. Out of 50 cases, fourty two cases were diagnosed as benign meningiomas (WHO Grade-I). Six cases were of atypical meningiomas (WHO grade II). Two cases were diagnosed as anaplastic meningiomas (WHO grade III).Conclusions: It can be concluded from the findings of present study that meningiomas are more common in females than males with grade I meningiomas outnumber the grade II and grade III meningiomas.

scholarly journals Study of Congenital Ocular Anomalies Prevalent in Routine Eye OPD in a Tertiary Care Hospital

2019 ◽  
pp. 1-7
Author(s):  
Arvind Kumar ◽  
Abha Shukla ◽  
Dinesh Matoli
Keyword(s):  
Genetic Counselling ◽  
Congenital Anomalies ◽  
Tertiary Care Hospital ◽  
Low Vision ◽  
Tertiary Care ◽  
Current Treatment ◽  
Congenital Glaucoma ◽  
Care Hospital ◽  
Visual Rehabilitation ◽  
Time Of Presentation

Aims: Congenital ocular anomalies require treatment, visual rehabilitation and genetic counselling. Goes undetected in neonates and children due to lack of routine eye checkup. Diagnosed later during eye examination or when come for disability certificate. Study Design: Prospective and observational study. Place and Duration of Study: We conducted study at tertiary care hospital, over a period of six months (from January 2018 to June 2018). Methodology: Patients with congenital ocular anomalies irrespective of their age were identified. Findings were confirmed by detailed ocular examination and investigations when required. Whatever best management like correcting refractive error, surgery, low vision aids or rehabilitation was advised. Those having acquired defects giving similar appearance as in congenital anomalies, cases of ocular trauma, infections, with prior surgical intervention were excluded. Results: Over a period of six months 128 eyes were detected with congenital ocular anomalies. The most common anomalies were microphthalmos, microcornea and iris coloboma seen in 85 eyes. Other congenital anomalies were congenital cataract, nystagmus, anophthalmos, aniridia, congenital glaucoma, Ankyloblepharon, coloboma of disc, congenital esotropia, lid coloboma, congenital ptosis, axenfield anomaly, limbal dermoid. Conclusion: Patient with congenital ocular anomalies and their parents should be counseled regarding possible current treatment, visual prognosis and genetic counselling regardless of age and time of presentation.

scholarly journals Atypical presentation of immunoglobulin G4-related disease as subglottic stenosis: a case-based review

2021 ◽  
Author(s):  
Belén Atienza-Mateo ◽  
Teresa Díaz de Terán-López ◽  
Javier Gómez-Román ◽  
Laura Sánchez ◽  
Roberto Mons-Lera ◽  
...  
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Histological Finding ◽  
Subglottic Stenosis ◽  
Caucasian Woman ◽  
Care Hospital ◽  
Rare Entity ◽  
Immunoglobulin G4 ◽  
Related Disease ◽  
Oral Glucocorticoids

Abstract Background Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory pathology that has been reported to affect principally the retroperitoneum, hepatobiliary system, salivary glands, orbital structures or lymph nodes. However, IgG4-RD with laryngeal involvement is a very rare entity. Our aims were to describe a case of subglottic stenosis as first and only manifestation of IgG4-RD and review the literature. A patient with IgG4-RD affecting the larynx that presented as subglottic stenosis is described. A MEDLINE database search of IgG4-RD cases with laryngopharyngeal manifestations was also conducted. A 30-year-old Caucasian woman was referred to a tertiary care hospital for dyspnea on exertion, which had been increasing for the last 4 months. Medical and surgical procedures revealed a subglottic stenosis, with a histological finding of IgG4 positive plasma cell infiltration. There was no evidence of other organ involvement. She was successfully treated with oral glucocorticoids and rituximab infusions. Glucocorticoids were rapidly tapered and the rituximab regimen was optimized, with no evidence of relapses. In the literature review, we found a total of 12 reported cases with laryngopharyngeal involvement, two of them with subglottic stenosis. IgG4-RD of the larynx is rare but should be considered after excluding more common disorders.

Incidence of post-intubation subglottic stenosis in children: prospective study

2013 ◽  
Vol 127 (4) ◽  
pp. 399-403 ◽  
Author(s):  
C Schweiger ◽  
P J Cauduro Marostica ◽  
M M Smith ◽  
D Manica ◽  
P R Antonacci Carvalho ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Endotracheal Intubation ◽  
Paediatric Intensive Care Unit ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Subglottic Stenosis ◽  
Care Hospital ◽  
Post Intubation

AbstractObjective:To evaluate the incidence of subglottic stenosis in children undergoing endotracheal intubation.Methods:Children in the paediatric intensive care unit of a tertiary care hospital were considered eligible for inclusion if they received endotracheal intubation for more than 24 hours. After extubation, children underwent flexible fibre-optic nasolaryngoscopy. Based on this first evaluation, they were divided into two groups: ‘acute normal’, with mild laryngeal alterations or normal findings; and ‘acute alterations’, with moderate to severe laryngeal alterations. Further laryngoscopic follow up (7–10 days later) was undertaken for those children in the acute normal group who developed symptoms during follow up (after discharge from the intensive care unit), and for all children in the acute alterations group. Children were then classified into two final groups: ‘normal final examination’, with no chronic changes; and ‘subglottic stenosis’.Results:We included 123 children. The incidence of subglottic stenosis was 11.38 per cent (95 per cent confidence interval, 6.63–17.94 per cent). All the children who developed subglottic stenosis had had moderate to severe alterations immediately after extubation.Conclusion:This incidence of subglottic stenosis is quite high and needs further investigation to identify risk factors.

scholarly journals COLORECTAL CARCINOMA

2013 ◽  
Vol 20 (06) ◽  
pp. 1014-1018
Author(s):  
HAMAD RANA ◽  
SHAHID MAHMOOD ◽  
SOSAN SHAHID ◽  
Muhammad Munir ◽  
Mulazam Hussain Bukhari
Keyword(s):  
Tertiary Care Hospital ◽  
Early Stage ◽  
Tertiary Care ◽  
Colonic Carcinoma ◽  
Care Hospital ◽  
Cross Sectional ◽  
Modes Of Presentation ◽  
Well Differentiated ◽  
Time Of Presentation ◽  
Mean Time

Introduction: Prognosis is excellent in colonic carcinoma in case of well differentiated growth. All efforts must be done todiagnose the malignancy at an earlier stage for a better outcome specially if it is well differentiated growth. Objectives: To compare thedifferent modes of presentation of carcinoma of large bowel in a tertiary care hospital and their association with pathological findings.Material & Methods: It is a cross sectional retrospective study. Patients with histological proof of carcinoma were included in the study.Data over the period of two year was collected and analyzed. Results: This study included one hundred patients. Mean age was 49.56years and 56 % of the patients were males. 40 % of the patients present between the ages of 40 to 60 years. Mean time of start ofsymptoms and the time of presentation in the hospital was 6.5 months ranges from 1 to 24 months. 76 % of the patients had history ofaltered bowel habits and 60% had anorexia and weight loss. 41.66% of patients had well differentiated growth while 37.55% of patientshad moderately differentiated adenocarcinoma. Conclusions: Majority of the patients with colonic carcinoma had well or moderatelydifferentiated growth. If they are diagnosed and properly treated at an early stage, outcome is good.

scholarly journals Epidemiological study of intracranial meningiomas in a tertiary care hospital

2019 ◽  
pp. 80-86
Author(s):  
Avdhesh Shukla ◽  
Asheesh Kumar Gupta ◽  
Anand Sharma ◽  
S. N. Iyengar
Keyword(s):  
Histological Grade ◽  
Tertiary Care ◽  
Care Hospital ◽  
Histological Variants ◽  
Histological Variant ◽  
Extent Of Surgery ◽  
Cns Tumours ◽  
Grade Ii ◽  
Cns Neoplasms ◽  
Grade Iii

Meningiomas are tumours that arise from the meningothelial cells. Most of these tumours are intracranial; some are intraspinal and few extra cranial. There are many histological variants classified into three grades depending on clinical behaviour. Classification is important for determining the modality of treatment. Objectives: To study the incidence, location, sex and age predilection, histological variants and grading of meningiomas based on WHO 2007 classification and recurrence if present. Materials and methods: All 200 cases of meningiomas. Based on Histological features, typing and grading of meningiomas was done as per the WHO 2007 classification of Meningiomas. Age, Sex incidence, Location of meningiomas were studied. Results: Meningiomas comprised 26.17% of all CNS tumours during the study period. Of 764 CNS tumours, 200 were meningiomas. Most of them were intracranial, predominantly involving the convexities of brain, females and the 41 – 50 age group. Of these, 180 were benign grade I tumours, 12 were grade II and 8 were grade III. The most common histological variant was fibroblastic and meningothelial. Grade II and Grade III tumours commonly recurred. Conclusion: Meningiomas are slow-growing tumours arising from the meningothelial cells accounting for 26.17% of all CNS neoplasms showing a variety of histological patterns, more common in women, predominantly Grade I tumours. Recurrence of tumours depends on histological grade and extent of surgery.

scholarly journals EVALUATION OF EFFECTIVENESS OF SCLEROTHERAPY FOR GRADE II HAEMORRHOIDS IN A TERTIARY CARE HOSPITAL IN CENTRAL INDIA

2021 ◽  
Vol 5 (10) ◽  
Author(s):  
Gulshan Kumar
Keyword(s):  
Tertiary Care Hospital ◽  
Negative Impact ◽  
Tertiary Care ◽  
Central India ◽  
Injection Sclerotherapy ◽  
Care Hospital ◽  
Eligibility Criteria ◽  
Cross Sectional ◽  
Key Words Haemorrhoids ◽  
Grade Ii

Background: Haemorrhoids is an anal disorder that has a negative impact on one's quality of life by causing severe pain and discomfort. Sclerotherapy injections are often used to treat haemorrhoids. Aims: The aim of this study was to see if sclerotherapy could benefit with grade II haemorrhoids. Methods: The research was a two-year hospital-based cross-sectional study of patients diagnosed with grade II haemorrhoids who visited the general surgery department of a tertiary care hospital. The research enlisted the participation of 100 patients. One of the eligibility criteria was that participants must be between the ages of 18 and 70 and have been diagnosed with grade II haemorrhoids. Results: There were 76 patients with grade II haemorrhoids who had no underlying conditions and 24 patients with grade II haemorrhoids who had cirrhosis of the liver with portal hypertension out of a total of 100 patients. Males outnumbered females by a factor of two (68 males and 32 females). The age group that contributed the most was 50 to 60 years old (54 percent). Conclusion: Injection sclerotherapy has been found to be a safe and cost-effective approach for the non-surgical treatment of haemorrhoids. Key Words: Haemorrhoids, Sclerotheraphy, II-degree Haemorrhoids.

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