The Change Rule of Peripheral Blood T Lymphocyte Subsets in Malignant Solid Tumor Patients and Its Clinical Significance in Radioactive Damage and Prognosis Analysis

2018 ◽  
Vol 08 (04) ◽  
pp. 408-415
Author(s):  
玉婷 王
Keyword(s):  
Clinical Significance ◽  
T Lymphocyte ◽  
Solid Tumor ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
Tumor Patients ◽  
T Lymphocyte Subsets ◽  
Malignant Solid Tumor

scholarly journals Changes in T Lymphocyte Subsets in Different Tumors Before and After Radiotherapy: A Meta-analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Qin Wang ◽  
Shangbiao Li ◽  
Simiao Qiao ◽  
Zhihao Zheng ◽  
Xiaotong Duan ◽  
...  
Keyword(s):  
Immune Response ◽  
T Lymphocytes ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
Meta Analysis ◽  
Tumor Patients ◽  
T Lymphocyte Subsets ◽  
Cd8 T Lymphocytes ◽  
Before And After

PurposeRadiation therapy (RT) induces an immune response, but the relationship of this response with tumor type is not fully understood. This meta-analysis further elucidated this relationship by analyzing the changes in T lymphocyte subsets in different tumors before and after radiotherapy.MethodsWe searched English-language electronic databases including PubMed, EMBASE, and the Cochrane Library to collect studies on the changes in peripheral blood CD3+ T lymphocytes, CD4+ T lymphocytes, and CD8+ T lymphocytes before and after radiotherapy in tumor patients from January 2015 to April 2021. The quality of the included literature was evaluated using the NOS scale provided by the Cochrane Collaboration, and statistical software RevMan 5.4 was used to analyze the included literature. P<0.05 was considered to indicate statistical significance.ResultsA total of 19 studies in 16 articles involving 877 tumor patients were included. All data were collected within 1 month before or after radiotherapy. Meta-analysis showed that numbers of CD3+ T lymphocytes (SMD: -0.40; 95% CI [-0.75, -0.04]; p = 0.03) and CD4+ T lymphocytes (SMD: -0.43; 95% CI: [-0.85, -0.02]; p = 0.04) were significantly reduced after radiotherapy compared with before treatment, but there was no statistically significant difference for CD8+ T lymphocytes (SMD: 0.33; 95% CI: [-0.88, 0.74]; p = 0.12). Subgroup analysis showed that peripheral blood T lymphocytes decreased in head and neck cancer. However, in prostate cancer and breast cancer, there was no significant change in peripheral blood. 1 month after radiotherapy, it has a potential proliferation and activation effect on lymphocytes in esophageal cancer and lung cancer. The results showed that CD8+T lymphocytes increased in peripheral blood after SBRT. Radiotherapy alone reduced CD3+ T lymphocyte numbers.ConclusionsWithin 1 month of radiotherapy, patients have obvious immunological changes, which can cause apoptosis and reduction of T lymphocytes, and affect the balance of peripheral blood immune cells. The degree of immune response induced by radiotherapy differed between tumor types.

scholarly journals Clinical Significance of Peripheral Blood T Lymphocyte Subsets inHelicobacter pylori-Infected Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Yuka Satoh ◽  
Hatsue Ogawara ◽  
Osamu Kawamura ◽  
Motoyasu Kusano ◽  
Hirokazu Murakami
Keyword(s):  
Clinical Significance ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
T Lymphocyte Subsets

Effect of moxibustion on T lymphocyte subsets in peripheral blood of rats with gastric cancer

2019 ◽  
Vol 17 (3) ◽  
pp. 161-167 ◽  
Author(s):  
Jing Tan ◽  
Ren-da Yang ◽  
Huan Zhao ◽  
Zhuo-jun Peng ◽  
Li-zhi Ouyang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
T Lymphocyte Subsets

scholarly journals Disease activity prediction and prognosis of anti-GBM nephritis based on T lymphocyte subset ratios

2021 ◽  
Vol 35 ◽  
pp. 205873842110393
Author(s):  
Dan Zhang ◽  
Fan Zhang ◽  
Meiling Liu ◽  
Mingchao Zhang ◽  
Jiong Zhang ◽  
...  
Keyword(s):  
Disease Activity ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
Activity Index ◽  
Renal Tissue ◽  
Renal Outcome ◽  
T Lymphocyte Subsets ◽  
Significant Difference ◽  
Renal Prognosis

Introduction Cell-mediated autoimmunity, especially the autoreactivity of T cells, is known to underlie the initiation of anti-glomerular basement membrane disease. However, the T lymphocyte subsets that determine the disease activity, renal fibrosis, and prognosis of anti-GBM disease have not been clearly elucidated. Methods The T lymphocyte subsets (CD4+ and CD8+) were examined on peripheral blood and renal biopsy tissues from 65 patients with biopsy proven anti-GBM disease. Patients were divided into the high ratio group and low ratio group according to the cutoff values in the receiver operating characteristic curve analysis. The correlations of T lymphocyte subsets with clinical, pathological data, and renal outcome were analyzed. Results By the end of follow-up, 45 patients (69.2%) developed end-stage renal disease (ESRD). In peripheral blood, the CD4+/CD8+ ratio showed a predictive ability with a sensitivity and specificity of 91.3% and 52.9%, respectively, which gave rise to a cutoff value of 0.89. There was a significant difference in the activity index between these two groups (3.91 ± 1.38 vs. 2.89 ± 1.13, p = 0.007). In the renal tissues, the CD4+/CD8+ ratio had the optimal cutoff point of 0.82 with a sensitivity of 57.8% and specificity of 85%. The renal activity index was higher for the renal tissues with high CD4+/CD8+ ratios than that of tissues with low CD4+/CD8+ ratios (4.32 ± 1.55 vs. 3.37 ± 1.41, p = 0.016). Peripheral blood CD4+/CD8+ ratios of ≥0.89 or renal tissue CD4+/CD8+ ratios of < 0.82 positively correlated with poor renal prognosis in patients with anti-GBM nephritis. Conclusions The CD4+/CD8+ ratio was associated with renal activity index both in peripheral blood and renal tissue and predicts the renal prognosis of patients with anti-GBM nephritis.

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