Granulosa Cell Tumor In A Spayed Young Queen

A four years old cat was presented to Clinic of Obstetrics and Gynaecology with complaints of weakness, inappetency, vomiting and estrus signs although it was spayed. Blood tests, radiography and ultrasonography revealed abdominal mass and uterine stump which were then removed surgically. Multilobular mass was defined as solid granulosa cell tumor (GCT). Increase of estrogen (E2) and insulin-like growth factor-1 (IGF-1) values were detected on the 10th postoperative day. On the 40th postoperative day, the cat was brought to Internal Medicine Clinic with the complaints of weakness, inappetency and cachexia. Anemia, leucocytosis, uremia, hyperglycemia, sensitiveness and pain in the right abdomen were determined. A tumor was detected in the liver by radiography and ultrasonography and was suspected to be GCT metastasis. Despite medical therapy, the cat died after four months. In conclusion; retained ovarian tissue after erroneous ovariohysterectomy may cause, regular estrus signs and GCT development. Even if GCTs are removed by surgical approach, they have metastatic potential that deteriorates the prognosis. Evaluating IGF-1 and E2 in the short postoperative term are beneficial for determining the metastatic potential of GCTs.

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Multiple recurrence of granulosa cell tumor of the ovary: A case report and literature review

10.1055/s-0039-1685319 ◽

2016 ◽

Author(s):

Varkha Chandra ◽

Sandhya Jain ◽

Neerja Goel ◽

Bindia Gupta ◽

Shalini Rajaram

Keyword(s):

Case Report ◽

Granulosa Cell ◽

Adnexal Mass ◽

Malignant Tumors ◽

Abdominal Mass ◽

Pelvic Mass ◽

Granulosa Cell Tumor ◽

Cell Tumor ◽

Surgical Staging ◽

Granulosa Cell Tumors

Introduction: Granulosa cell tumors comprise approximately 5% of all ovarian malignancy and account for 70% of malignant sex cord stromal tumors. Granulosa cell tumors have been diagnosed from infancy, the peak incidence being perimenopausal age. The potential of malignancy of these tumors is low, recurrences are often late and found in 10-33% of cases. Case Report: A 32-year-old P1L1 presented with large abdominal mass for which she underwent staging laparotomy with debulking surgery. She was a known case of granulosa cell tumor in the past and had undergone three laparotomies, along with chemotherapy. At the age of 13 yrs, she was diagnosed with a stage IA granulosa cell tumor (GCT) of the ovary first time. She underwent surgical staging and removal of left sided adnexal mass, after which she was asymptomatic for 7 years. In 2003 she again presented with lump abdomen for which she underwent resection of adnexal mass, histopathology was consistent with recurrent GCT. After second surgery she also received two cycles of chemotherapy. Despite adjuvant chemotherapy, patient presented again after three years in 2006 with adnexal mass and was found to have a third recurrence. At that time, she received 6 cycles of chemotherapy and the mass regressed. Meanwhile she got married and had one child. After four year in 2010 she again presented with lump abdomen and she underwent surgical staging, total abdominal hysterectomy with right salphingo ophorectomy along with removal of mass. After five year in 2015 she again presented with lump abdomen; there was a large pelvic mass which was removed and patient referred for chemotherapy. Discussion: GCTS which a rare malignant tumors of ovary tend to be associated with late recurrences. Although most recurrences occurs within 10 years after initial diagnosis, there are occasional reports of recurrences after10 years. We experienced the rare case of a patient who relapsed multiple times over 20 years, despite surgical and targeted treatment. Conclusion: The long history of granulosa cell tumor highlights the importance of extended follow up of the patient.

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Biphasic Malignant Testicular Sex Cord-Stromal Tumor in a Cotton-top Tamarin (Saguinus oedipus) with Review of the Literature

Veterinary Pathology ◽

10.1354/vp.45-6-922 ◽

2008 ◽

Vol 45 (6) ◽

pp. 922-927 ◽

Cited By ~ 4

Author(s):

J. H. Yearley ◽

N. King ◽

X. Liu ◽

E. H. Curran ◽

S. P. O'Neil

Keyword(s):

Granulosa Cell ◽

Abdominal Mass ◽

Granulosa Cell Tumor ◽

Needle Aspiration ◽

Cell Tumor ◽

Stromal Tumor ◽

Histologic Examination ◽

Saguinus Oedipus ◽

Abdominal Tumor ◽

Sex Cord Stromal Tumor

A 20–year old male cotton-top tamarin ( Saguinus oedipus) was presented with unilateral enlargement of an intrascrotal testicle. Fine-needle aspiration cytology demonstrated a neoplastic population with Call-Exner-like bodies and features of malignancy. The animal was castrated, and histologic examination revealed a biphasic sex cord-stromal tumor, with one region resembling Sertoli-cell tumor and one region resembling granulosa-cell tumor, with extensive microfollicular pattern and many Call-Exner bodies. Eight months after castration, the animal was euthanized on discovery of a caudal abdominal mass that displaced organs, was highly infiltrative, and extended into the paravertebral musculature with lysis of vertebral bone. Metastases to lymph node and lung were also present. Histologic examination of the abdominal tumor showed multifocal formation of Call-Exner bodies in an otherwise highly dedifferentiated population. Positive immunolabeling for alpha inhibin confirmed the sex cord-stromal origin of the abdominal and paravertebral tumor masses. This case has similarities to malignant testicular granulosa-cell tumor of humans.

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Two interesting cases of granulosa cell tumor: A case report

10.1055/s-0039-1685309 ◽

2016 ◽

Author(s):

Pannu Savita ◽

Khullar Harsha

Keyword(s):

Granulosa Cell ◽

Ovarian Tissue ◽

Clinical Manifestations ◽

Granulosa Cell Tumor ◽

Good Prognosis ◽

Cell Tumor ◽

Ovarian Malignancy ◽

Age Group ◽

Granulosa Cell Tumors ◽

Follicular Cyst

Introduction: Granulosa cell tumor (GCT) is an ovarian malignancy that arise from granulosa cells of the ovary. This tumour is a type of the sex cord-gonadal stromal tumour. GCT have good prognosis in comparison with other epithelial tumors. Methodology: Two cases of granulosa cell tumors were diagnosed in sir Ganga ram hospital, Rajender Nagar, New Delhi in December 2015 and January 2016. The patient’s age, clinical manifestations, radiological and histopathological findings were evaluated. One was in perimenopausal age group and other case was in postmenopausal age group. The clinical manifestations were menorrhagia and abdominal pain. Ultrasonographically, in one case focal hypoechoic zone showing peripheral hypervascularity with possibility of old hemorrhage follicular cyst was seen and in other case of granulosa cell tumors was both solid and cystic areas were seen. Histologically, variety of patterns like diffuse, trabecular, nodular, sheets, nests and fascicular patterns with nuclear grooving in ovarian tissue. In addition endometrial findings were suggestive of simple hyperplasia without atypia. Treatment modalility used was surgery i.e. Total hysterectomy and bilateral salpingo-oophorectomy in both cases. Conclusion: Granulosa cell tumor of the ovary is a rare ovarian malignancy. Endometrial pathology to rule out endometrial carcinoma specially when postmenopausal bleeding is concomitant finding is advised. Radical surgery is usually not required.

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Adult Granulosa Cell Tumor in Pregnancy: A New Case and a Review of the Literature

Healthcare ◽

10.3390/healthcare9111455 ◽

2021 ◽

Vol 9 (11) ◽

pp. 1455

Author(s):

Sofia Guidi ◽

Vincenzo Berghella ◽

Giovanni Scambia ◽

Anna Fagotti ◽

Annalisa Vidiri ◽

...

Keyword(s):

Cesarean Delivery ◽

Granulosa Cell ◽

Abdominal Mass ◽

Granulosa Cell Tumor ◽

Cell Tumor ◽

Prior History ◽

Review Of The Literature ◽

Platinum Based Chemotherapy ◽

History Of ◽

In Pregnancy

Granulosa cell tumors are rare ovarian tumors that can arise during pregnancy. We present a new case of recurrent adult granulosa cell tumor (AGCT) in pregnancy and a systematic review of the literature. The new case described is a 41-year-old woman G5P1122 with a prior history of AGCT that was referred to our center at 29 weeks because of a symptomatic abdominal mass, compatible with a possible recurrence of AGCT. At 36 + 3 weeks, she underwent a cesarean delivery for preterm labor and a total hysterectomy with a radical surgical staging. A healthy female infant was delivered. The patient received a platinum-based chemotherapy, with a 26-month follow-up negative for recurrence. Analyzing our case with the four identified by the literature review, three were recurrent and two were primary AGCT. Only one required surgery for AGCT at 15 weeks, while another underwent chemotherapy in pregnancy. In the other three cases, surgery for AGCT was done at the time of cesarean delivery. There were three cases of preterm delivery. All five pregnancies resulted in the birth of live babies with weight adequate for gestational age. In conclusion, AGCT diagnosed in pregnancy is rare, reported in only five cases. All gave birth to live babies in the third trimester, and maternal outcome at up to 18 months showed no recurrence.

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Occurrences of Dysgerminoma in the Left Ovary and of Granulosa-cell Tumor in the Right Ovary in a Japanese Black Cow

Journal of the Japan Veterinary Medical Association ◽

10.12935/jvma1951.56.592 ◽

2003 ◽

Vol 56 (9) ◽

pp. 592-594

Author(s):

Aya SHIBAHARA ◽

Shunichi KAMIMURA ◽

Takaaki ANDO ◽

Hitomi KOIKE ◽

Noriaki MIYOSHI ◽

...

Keyword(s):

Granulosa Cell ◽

Granulosa Cell Tumor ◽

Cell Tumor ◽

Left Ovary ◽

The Right

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Ultrasound feature discordance in a bilateral juvenile ovarian granulosa cell tumor: A case report

10.21203/rs.3.rs-143384/v1 ◽

2021 ◽

Author(s):

Li Zhang ◽

Sheng Cai ◽

Yahong Wang ◽

Ying Wang ◽

Zhitong Ge ◽

...

Keyword(s):

Granulosa Cell ◽

Granulosa Cell Tumor ◽

Exploratory Laparotomy ◽

Cell Tumor ◽

Cystic Lesions ◽

Ovarian Granulosa Cell ◽

Ovarian Granulosa Cell Tumor ◽

The Right ◽

Cystic Masses

Abstract BackgroundAs a rare ovarian stromal tumor, the juvenile ovarian granulosa cell tumor (JGCT) is mainly seen in premenstrual and young women. It associates with high malignancy and recurrence rate, and early diagnosis and treatment could improve prognosis. Most cases are unilateral solid-cystic or solid masses, while unilocular cystic masses are rarely seen. As cystic ovarian tumors are often misdiagnosed as benign cystic lesions or functional cysts, cystic JGCT should not be overlooked.Case presentationWe report this special case of a 10-year-old female patient. It’s the first reported JGCT with completely inconsistent bilateral imaging manifestations, including an extremely rare unilocular cystic JGCT. A large solid-cystic JGCT appeared in her left ovary, and left adnexal resection was performed. A unilocular cyst occurred in the right ovary two years later. It was with a regular shape and smooth inner wall, mimicking a benign cyst. Since the patient was young and had the desire to preserve the right ovary, follow-up was initially recommended. However, the cyst size increased rapidly and exploratory laparotomy was finally performed. Pathology showed a unilocular cystic JGCT.ConclusionsAs cystic masses in young patients are easily misdiagnosed as benign or physiologic lesions, this case emphasizes the importance of postoperative follow-up for JGCTs. Exploratory laparotomy of persistent cystic lesions should be considered when necessary.

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Granulosa Cell Tumour – A Rare Presentation at Age Twenty

Pakistan Journal of Medicine and Dentistry ◽

10.36283/pjmd9-3/018 ◽

2020 ◽

Author(s):

Munazza Anis

Keyword(s):

Granulosa Cell ◽

Tertiary Care ◽

Granulosa Cell Tumor ◽

Cell Tumor ◽

Care Hospital ◽

Age Group ◽

Rare Presentation ◽

Rare Type ◽

Juvenile Granulosa Cell Tumor ◽

The Right

Granulosa cell tumor is a rare type of ovarian tumor, which arises from sex cord stroma. Histologically this tumor has two types and is named according to the common age group they affect; adult granulosa cell tumor (AGCT) and juvenile granulosa cell tumor. AGCT constitutes 2-5% of all ovarian cancers. Mostly present in women of age > 40 years. In this case report, we discussed the role of conservative surgery in young adult reported with granulosa cell tumor. An unmarried teenage girl presented at a private tertiary care hospital with abdominal pain and abdominal distention. Radiological examinations suggested a mass originating from the right ovary for which laparotomy was done and a ruptured cyst was found near the right ovary with a mass adherent to surrounding peritoneal viscera. Right ovarian cystectomy along with omental biopsy and left ovarian biopsy was performed. Rare presentation of this tumor will help clinicians to not categorize the type histologically with the age group.

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Ovarian Adult Granulosa Cell Tumor – a rare case report

Nepal Journal of Obstetrics and Gynaecology ◽

10.3126/njog.v13i1.21621 ◽

2018 ◽

Vol 13 (1) ◽

pp. 57-60

Author(s):

Rijuta Joshi ◽

Gehanath Baral ◽

Karishma Malla

Keyword(s):

Granulosa Cell ◽

Abdominal Mass ◽

Granulosa Cell Tumor ◽

Total Abdominal Hysterectomy ◽

Late Recurrence ◽

Abdominal Hysterectomy ◽

Cell Tumor ◽

Rare Case Report ◽

Stage Ia ◽

Post Menopausal

Introduction: Adult granulosa cell tumor is a rare tumor which accounts for 1% of all ovarian tumors. They usually present with postmenopausal bleeding and abdominal mass. Inhibin is used as the tumor marker.Case: A 76 years multiparous post-menopausal women presented with vaginal bleeding for past three years and painless huge mass in lower abdomen. She underwent total abdominal hysterectomy with bilateral salphingo-oophorectomy with bilateral pelvic lymphnode dissection with appendectomy. Histopathology showed the adult granulosa cell tumor with few mitosis, Stage IA. Her postoperative period was uneventful.Conclusion: Surgery is the mainstay of treatment of granulosa cell tumor and chemotherapy is indicated in advanced cases. Although they have better prognosis, life-long follow up is advised to detect late recurrence.

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Multiple recurrence of granulosa cell tumor of the ovary: A case report and literature review

10.1055/s-0039-1685296 ◽

2016 ◽

Author(s):

Varkha Chandra ◽

Sandhya Jain ◽

Neerja Goel ◽

Bindia Gupta ◽

Shalini Rajaram

Keyword(s):

Case Report ◽

Granulosa Cell ◽

Adnexal Mass ◽

Malignant Tumors ◽

Abdominal Mass ◽

Pelvic Mass ◽

Granulosa Cell Tumor ◽

Cell Tumor ◽

Surgical Staging ◽

Granulosa Cell Tumors

Introduction: Granulosa cell tumors comprise approximately 5% of all ovarian malignancy and account for 70% of malignant sex cord stromal tumors. Granulosa cell tumors have been diagnosed from infancy, the peak incidence being perimenopausal age. The potential of malignancy of these tumors is low, recurrences are often late and found in 10-33% of cases. Case Report: A 32-year-old P1L1 presented with large abdominal mass for which she underwent staging laparotomy with debulking surgery. She was a known case of granulosa cell tumor in the past and had undergone three laparotomies, along with chemotherapy. At the age of 13 years, she was diagnosed with a stage IA granulosa cell tumor (GCT) of the ovary first time. She underwent surgical staging and removal of left sided adnexal mass, after which she was asymptomatic for 7 years. In 2003 she again presented with lump abdomen for which she underwent resection of adnexal mass, histopathology was consistent with recurrent GCT. After second surgery she also received two cycles of chemotherapy. Despite adjuvant chemotherapy, patient presented again after three years in 2006 with adnexal mass and was found to have a third recurrence. At that time, she received 6 cycles of chemotherapy and the mass regressed. Meanwhile she got married and had one child. After four year in 2010 she again presented with lump abdomen and she underwent surgical staging, total abdominal hysterectomy with right salphingo ophorectomy along with removal of mass. After five year in 2015 she again presented with lump abdomen; there was a large pelvic mass which was removed and patient referred for chemotherapy. Discussion: GCTS which a rare malignant tumors of ovary tend to be associated with late recurrences. Although most recurrences occurs within 10 years after initial diagnosis, there are occasional reports of recurrences after10 years. We experienced the rare case of a patient who relapsed multiple times over 20 years, despite surgical and targeted treatment. In conclusion the long history of granulosa cell tumor highlights the importance of extended follow up of the patient.

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Adult Granulosa cell tumor: A small mass producing troublesome morbidity to a woman

Journal of Bahria University Medical and Dental College ◽

10.51985/jbumdc2018030 ◽

2018 ◽

Vol 08 (02) ◽

pp. 126-128

Author(s):

Khalida Nasreen ◽

Samreen Iqbal

Keyword(s):

Granulosa Cell ◽

Abdominal Mass ◽

Granulosa Cell Tumor ◽

Small Mass ◽

Cell Tumor ◽

Adult Type ◽

Granulosa Cell Tumors ◽

Large Size ◽

Present Case Study

Granulosa cell tumors are sex-cord stromal tumor ofovary, a rare neoplasmaccounting for approximately 3-5% of all ovarian malignancies. Hormone producing tumor, a total of 95% of all GCTs are adult type and of large size. A majority of women present with abdominal mass and diagnosis made on histopathology. While small size symptoms producing Granulosa cell tumors are rare and it’s a rare virilizing tumor of adolescents. Adult Granulosa cell tumor is a clinically and molecularly unique subtype of ovarian cancer. The present case study reports on a case of a small size Granulosa cell tumor producing postmenopausal bleeding in 56-year-old woman.

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