scholarly journals The future of genomics in Ireland – focus on genomics for health

2020 ◽  
Vol 3 ◽  
pp. 89
Author(s):  
Cathal Seoighe ◽  
Adrian P. Bracken ◽  
Patrick Buckley ◽  
Peter Doran ◽  
Robert Green ◽  
...  
Keyword(s):  
Biomedical Research ◽  
Clinical Applications ◽  
Genomic Research ◽  
Genome Research ◽  
Clinical Genomics ◽  
Health Strategy ◽  
The World ◽  
Key Issues ◽  
Catch Up ◽  
Industry Sectors

Genomics is revolutionizing biomedical research, medicine and healthcare globally in academic, public and industry sectors alike. Concrete examples around the world show that huge benefits for patients, society and economy can be accrued through effective and responsible genomic research and clinical applications. Unfortunately, Ireland has fallen behind and needs to act now in order to catch up. Here, we identify key issues that have resulted in Ireland lagging behind, describe how genomics can benefit Ireland and its people and outline the measures needed to make genomics work for Ireland and Irish patients. There is now an urgent need for a national genomics strategy that enables an effective, collaborative, responsible, well-regulated, and patient centred environment where genome research and clinical genomics can thrive.  We present eight recommendations that could be the pillars of a national genomics health strategy.

scholarly journals Bridging the Divide between Genomic Science and Indigenous Peoples

2010 ◽  
Vol 38 (3) ◽  
pp. 684-696 ◽  
Author(s):  
Bette Jacobs ◽  
Jason Roffenbender ◽  
Jeff Collmann ◽  
Kate Cherry ◽  
LeManuel Lee Bitsói ◽  
...  
Keyword(s):  
Indigenous Peoples ◽  
Biomedical Research ◽  
Genetic Factors ◽  
Science Research ◽  
Developing Nations ◽  
Genomic Research ◽  
New Science ◽  
The World ◽  
History Of ◽  
Genomic Science

The new science of genomics endeavors to chart the genomes of individuals around the world, with the dual goals of understanding the role genetic factors play in human health and solving problems of disease and disability. From the perspective of indigenous peoples and developing countries, the promises and perils of genomic science appear against a backdrop of global health disparity and political vulnerability. These conditions pose a dilemma for many communities when attempting to decide about participating in genomic research or any other biomedical research. Genomic research offers the possibility of improved technologies for managing the acute and chronic diseases that plague their members. Yet, the history of biomedical research among people in indigenous and developing nations offers salient examples of unethical practice, misuse of data and failed promises. This dilemma creates risks for communities who decide either to participate or not to participate in genomic science research.

scholarly journals Traditional uses, phytochemistry, pharmacology and toxicity of Arisaema (Areaceae): a review

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Heena Ali ◽  
Ubaid Yaqoob
Keyword(s):  
Skin Irritation ◽  
Clinical Applications ◽  
Human Populations ◽  
Main Body ◽  
Anticancer Activities ◽  
Medicinal Uses ◽  
The World ◽  
Different Types ◽  
Tropical Areas ◽  
Medicinal Properties

Abstract Background The genus Arisaema (Areaceae), popularly known as cobra lilies and jack in pulpit is mainly found in temperate to tropical areas of all continents except South America, Europe and Australia and contain about more than 250 species. Arisaema genus is being used by the different folks of human populations for medicinal as well as food purposes. Arisaema plants are used for the treatment of different types of diseases. There have been several attempts to highlight different aspects of genus Arisaema by describing it in terms of phytochemistry and medicinal uses. The present study is, however, an attempt to put together all the former data available related to the phytochemistry and medicinal uses of genus Arisaema. Main body The phytochemicals of the plant include alkaloids, phenols, terpenes, flavonoids, lectins, saponins, glycosides, triterpenoids, stigmasterols, n-alkanes, n-alkanols sitosterols, campesterol, oxalates, coumarins, tannins etc. Moreover, the properties such as antioxidant, antifungal, antibacterial, insecticidal, antimicrobial, cytotoxic, nematocidal, antiallergic antitumour and anticancer activities are also shown by the plants belonging to genus Arisaema. Arisaema plants have been traditionally used to treat various ailments such as resolving phlegm, dampness, and to treat asthma, bronchitis, cold, cough, and laryngitis etc. It has been found that there are several species which are toxic by nature. The development of clinical applications of arisaematis rhizomes had been seriously constrained due to its toxic properties like, mouth and lingua pain, even respiration slowing and suffocation, mucous membrane and skin irritation etc. and this toxicity of arisaematis rhizomes is due to raphide components. Conclusions The collection of data available on the phytochemistry of genus Arisaema is not sufficient as further work is required to do on phytochemical and medicinal basis. The data available on phytochemistry and medicinal properties of the plants belonging to genus Arisaema throws light on various species of Arisaema which are medicinally important and have been exploited to treat different types of diseases in the world.

Guaranteed Sweet or Guaranteed Non–Sweet – Fruit and the Future of Hortical Pty Ltd

2003 ◽  
Vol 9 (2) ◽  
pp. 8-16
Author(s):  
John Jackson
Keyword(s):  
Business Models ◽  
Nir Spectroscopy ◽  
New Product ◽  
New Venture ◽  
Product Service ◽  
First Mover Advantage ◽  
The World ◽  
Infra Red ◽  
Key Issues ◽  
Viable Business

ABSTRACTWe pick up the case as the new venture moves from a decade of dedicated scientific research into the early stages of becoming a commercially viable business. The case considers the potential of the Near Infra Red (NIR) spectroscopy technology to revolutionise the fruit markets of the world as well as the realities of trying to change existing practices and culture. The dilemma of first-mover advantage as compared to learning from the mistakes of early competitors is included. Various possible business models are introduced. The case also asks the students to consider some of the key issues of a new product/service launch.

The World Bank's new health strategy

The Lancet ◽  
2007 ◽  
Vol 370 (9581) ◽  
pp. 28
Author(s):  
Helmut Hausner ◽  
Göran Hajak ◽  
Hermann Spießl
Keyword(s):  
Health Strategy ◽  
The World

scholarly journals Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPA

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Ângela C. B. Neves ◽  
Ivanna Hrynchak ◽  
Inês Fonseca ◽  
Vítor H. P. Alves ◽  
Mariette M. Pereira ◽  
...  
Keyword(s):  
Large Scale ◽  
Neuroendocrine Tumours ◽  
Radiochemical Yield ◽  
Clinical Applications ◽  
Clinical Use ◽  
Molar Activity ◽  
Neuropsychiatric Diseases ◽  
Recent Developments ◽  
Key Issues ◽  
Improved Methods

AbstractThe neurotracer 6-[18F] FDOPA has been, for many years, a powerful tool in PET imaging of neuropsychiatric diseases, movement disorders and brain malignancies. More recently, it also demonstrated good results in the diagnosis of other malignancies such as neuroendocrine tumours, pheochromocytoma or pancreatic adenocarcinoma.The multiple clinical applications of this tracer fostered a very strong interest in the development of new and improved methods for its radiosynthesis. The no-carrier-added nucleophilic 18F-fluorination process has gained increasing attention, in recent years, due to the high molar activities obtained, when compared with the other methods although the radiochemical yield remains low (17–30%). This led to the development of several nucleophilic synthetic processes in order to obtain the product with molar activity, radiochemical yield and enantiomeric purity suitable for human PET studies.Automation of the synthetic processes is crucial for routine clinical use and compliance with GMP requirements. Nevertheless, the complexity of the synthesis makes the production challenging, increasing the chance of failure in routine production. Thus, for large-scale clinical application and wider use of this radiopharmaceutical, progress in the automation of this complex radiosynthesis is of critical importance.This review summarizes the most recent developments of 6-[18F]FDOPA radiosynthesis and discusses the key issues regarding its automation for routine clinical use.

The Paradoxes of the Sustainability Thesis

2011 ◽  
pp. 93-99
Author(s):  
Ranabir Samaddar
Keyword(s):  
Sustainable Development ◽  
Technical Analysis ◽  
Fundamental Question ◽  
The World ◽  
Key Issues ◽  
Comprehensive Framework

The author's reflections on the concept of sustainability move within a historicalsociological frame, and it is in this context that the author arises a fundamental question: is the world able to sustain other wars and mass destructions or, instead, it is necessary to listen to a new need the path of sustainable development. The work gives a unique perspective on the birth and evolution of the concept of sustainability, as it does not focus on data and technical analysis, but places this issue in a comprehensive framework, illustrating a number of ties between the need for a path of sustainability and global key issues, and providing important secondary issues.

scholarly journals Local and National Belonging in A Globalised World

2011 ◽  
Vol 19 (2) ◽  
pp. 127-143 ◽  
Author(s):  
Tom Inglis ◽  
Susie Donnelly
Keyword(s):  
Mixed Method ◽  
National Identities ◽  
Global Flow ◽  
National Belonging ◽  
Social Survey ◽  
Rural And Urban ◽  
The World ◽  
Key Issues ◽  
Method Approach ◽  
International Social

The question of place is becoming more important in an increasingly globalised, cosmopolitan world. Has the global flow of culture and the movement of people around the world meant a decline in the importance of place as a form of identity? Have local, regional and national identities lost their significance for people? The article begins to explore these key issues. In particular it looks at Ireland which, from the 1990s, moved from being relatively insular and homogeneous to becoming one of the most globalised societies. The authors use a mixed method approach. First they examine data from the International Social Survey Project (ISSP) to see if there is any evidence of a decline in identity with place, how this varies between rural and urban dwellers, and levels of age and education. They then use findings from a qualitative study to examine the complex ways in which people talk about and identify with place, where they were brought up, where they live now and being Irish. The findings show that level of identity with place is still strong in Ireland and in some cases is increasing. The authors argue that increased identification with the local is an equal and opposite reaction to globalisation.

Sign in / Sign up

Export Citation Format

Share Document