scholarly journals Effect of dietary fat and fatty acids on liver lipid accumulation in fasted-refed rats.

1974 ◽  
Vol 38 (10) ◽  
pp. 1791-1796
Author(s):  
Yoritaka AOYAMA ◽  
Akira YOSHIDA ◽  
Kiyoshi ASHIDA
Keyword(s):  
Fatty Acids ◽  
Dietary Fat ◽  
Lipid Accumulation ◽  
Liver Lipid

Effect of Dietary Fat and Fatty Acids on Liver Lipid Accumulation in Fasted-refed Rats

1974 ◽  
Vol 38 (10) ◽  
pp. 1791-1796
Author(s):  
Yoritaka Aoyama ◽  
Akira Yoshida ◽  
Kiyoshi Ashida
Keyword(s):  
Fatty Acids ◽  
Dietary Fat ◽  
Lipid Accumulation ◽  
Liver Lipid

Effect of various dietary fat supplementations on liver lipid and glycogen of high-yielding dairy cows in the peripartal period

2008 ◽  
Vol 56 (1) ◽  
pp. 57-70 ◽  
Author(s):  
Roland Karcagi ◽  
Tibor Gaál ◽  
László Wágner ◽  
Ferenc Husvéth
Keyword(s):  
Fatty Acids ◽  
Dairy Cows ◽  
Dietary Fat ◽  
Liver Lipid ◽  
Total Lipid Content ◽  
Percutaneous Biopsy ◽  
Glycogen Metabolism ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Holstein Friesian

In a model experiment, Holstein-Friesian dairy cows were fed on a cornsilage-based diet supplemented with 11.75 MJ NE l per day of calcium soaps of palm oil fatty acids (CAS) or hydrogenated triglyceride (HTG) or without fat supplementation (control). All diets were fed to the cows over a period from 21 ± 3 days (d) prior to the expected calving to d 100 ± 5 postpartum. On d 25 (basal sample) and d 14 prepartum as well as on d 5 and 25 postpartum liver samples were collected by percutaneous biopsy. Total lipid content, fatty acid composition and glycogen of liver tissues were determined. At d 5 postpartum, both control and CAS cows had higher liver lipid (P < 0.05) and lower glycogen (P < 0.05) concentrations than cows in the HTG group. No significant (P < 0.05) differences were detected in liver fat content among the groups at d 14 prepartum or d 25 postpartum. The glycogen concentration slightly decreased in the liver of cows in each treatment group from d 14 prepartum to d 5 postpartum; however, this decrease was more intensive in both the control and CAS groups than in the HTG group. The variations in liver lipid concentrations were accompanied by significant changes in the proportion of C16:0, C16:1n-7, C18:0, C18:1n-9, C18:2n-6 and C20:4n-6 fatty acids in the liver lipids. The results show that HTG supplementation exerted more advantageous effects on liver lipid and glycogen metabolism than did CAS supplementation.

Temperature modulates liver lipid accumulation in Atlantic salmon (Salmo salarL.) fed low dietary levels of long-chain n-3 fatty acids

2016 ◽  
Vol 23 (4) ◽  
pp. 865-878 ◽  
Author(s):  
N.H. Sissener ◽  
B.E. Torstensen ◽  
M.A.G. Owen ◽  
N.S. Liland ◽  
I. Stubhaug ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Atlantic Salmon ◽  
Lipid Accumulation ◽  
Liver Lipid ◽  
Long Chain

scholarly journals Aqueous Extract of Pepino Leaves Ameliorates Palmitic Acid-Induced Hepatocellular Lipotoxicity via Inhibition of Endoplasmic Reticulum Stress and Apoptosis

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 903
Author(s):  
Jen-Ying Hsu ◽  
Hui-Hsuan Lin ◽  
Charng-Cherng Chyau ◽  
Zhi-Hong Wang ◽  
Jing-Hsien Chen
Keyword(s):  
Fatty Acid ◽  
Palmitic Acid ◽  
Er Stress ◽  
Lipid Accumulation ◽  
Hepg2 Cells ◽  
Target Genes ◽  
Liver Lipid ◽  
Antioxidant Response ◽  
Long Chain Fatty Acid ◽  
Nrf2 Expression

Saturated fatty acid is one of the important nutrients, but contributes to lipotoxicity in the liver, causing hepatic steatosis. Aqueous pepino leaf extract (AEPL) in the previous study revealed alleviated liver lipid accumulation in metabolic syndrome mice. The study aimed to investigate the mechanism of AEPL on saturated long-chain fatty acid-induced lipotoxicity in HepG2 cells. Moreover, the phytochemical composition of AEPL was identified in the present study. HepG2 cells treated with palmitic acid (PA) were used for exploring the effect of AEPL on lipid accumulation, apoptosis, ER stress, and antioxidant response. The chemical composition of AEPL was analyzed by HPLC-ESI-MS/MS. AEPL treatment reduced PA-induced ROS production and lipid accumulation. Further molecular results revealed that AEPL restored cytochrome c in mitochondria and decreased caspase 3 activity to cease apoptosis. In addition, AEPL in PA-stressed HepG2 cells significantly reduced the ER stress and suppressed SREBP-1 activation for decreasing lipogenesis. For defending PA-induced oxidative stress, AEPL promoted Nrf2 expression and its target genes, SOD1 and GPX3, expressions. The present study suggested that AEPL protected from PA-induced lipotoxicity through reducing ER stress, increasing antioxidant ability, and inhibiting apoptosis. The efficacy of AEPL on lipotoxicity was probably concerned with kaempferol and isorhamnetin derived compounds.

scholarly journals Lipid Accumulation and Chronic Kidney Disease

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 722 ◽  
Author(s):  
Zhibo Gai ◽  
Tianqi Wang ◽  
Michele Visentin ◽  
Gerd Kullak-Ublick ◽  
Xianjun Fu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Kidney Disease ◽  
Lipid Accumulation ◽  
Scavenger Receptor ◽  
Fatty Acid Uptake ◽  
Lipid Lowering ◽  
Fatty Acid Transport ◽  
Acid Uptake

Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic kidney disease (CKD), suggesting that lipid accumulation in the renal parenchyma is detrimental to renal function. Non-esterified fatty acids (also known as free fatty acids, FFA) are especially harmful to the kidneys. A concerted, increased FFA uptake due to high fat diets, overexpression of fatty acid uptake systems such as the CD36 scavenger receptor and the fatty acid transport proteins, and a reduced β-oxidation rate underlie the intracellular lipid accumulation in non-adipose tissues. FFAs in excess can damage podocytes, proximal tubular epithelial cells and the tubulointerstitial tissue through various mechanisms, in particular by boosting the production of reactive oxygen species (ROS) and lipid peroxidation, promoting mitochondrial damage and tissue inflammation, which result in glomerular and tubular lesions. Not all lipids are bad for the kidneys: polyunsaturated fatty acids (PUFA) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) seem to help lag the progression of chronic kidney disease (CKD). Lifestyle interventions, especially dietary adjustments, and lipid-lowering drugs can contribute to improve the clinical outcome of patients with CKD.

scholarly journals Supplemental Dietary Fat from Extruded Soybeans and Calcium Soaps of Fatty Acids for Lactating Dairy Cows

1993 ◽  
Vol 76 (1) ◽  
pp. 197-204 ◽  
Author(s):  
Yong Kook Kim ◽  
David J. Schingoethe ◽  
David P. Casper ◽  
Fenton C. Ludens
Keyword(s):  
Fatty Acids ◽  
Dairy Cows ◽  
Dietary Fat ◽  
Lactating Dairy Cows
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