Immune inflammation response in patients with obliterating atherosclerosis of lower limb arteries

10.12737/6447 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 0-0
Author(s):  
Бобровская ◽  
E. Bobrovskaya ◽  
Лазаренко ◽  
V. Lazarenko ◽  
Путинцева ◽  
...  

This article presents the results of a study of the immune status of 46 patients with lower extremities atherosclerosis obliterans before and after reconstructive surgery. To assess the nature of the immunologic changes the content of the markers were determined in systemic circulation and subcutaneous veins of the rear foot serum. It was established that patients suffering obliterating atherosclerosis of lower extremities had dysimmunoglobulinemia between the characteristics of systemic and local blood flow. The high content of markers of chronic inflammation - immunoglobulins of classes A, G, anti-inflammatory cytokines IL-1, IL-6 was detected especially in local blood flow both in pre and post-operative periods. The marked decrease was found in immunoglobulin class A in local blood flow compared to the pre-operative values by 6.87% (p=0.02), to 11.52% (p<0.05), 12,4% (p<0.05) after femoral-popliteal, aorta-femoral and interventional treatment respec-tively. The authors observed a decrease in circulating immune complexes after the reconstructive surgery in the systemic and local blood flow. A statistically significant decrease in circulating immune complexes was revealed in local blood flow after femoral-popliteal bypass surgery in 2 times (p=0.00001) and after angioplasty with stenting on 37,03% (p=0.0005).

1981 ◽  
Vol 19 (2) ◽  
pp. 332-340 ◽  
Author(s):  
Kaivilayil V. Johny ◽  
Mrinal K. Dasgupta ◽  
Thavisakdi Kovithavongs ◽  
John B. Dossetor

2021 ◽  
Vol 12 ◽  
Author(s):  
Shuyong Jia ◽  
Qizhen Wang ◽  
Hongyan Li ◽  
Xiaojing Song ◽  
Shuyou Wang ◽  
...  

Previous studies have explored the relationship between the complexity of local blood flow signals and heart rate variability (HRV) under different thermal stimulations. However, the relationship between the complexity of local blood flow signals and HRV in different positions is not clear. In this study, healthy participants were placed in different body positions. The bilateral blood flux and ECG were monitored, and refined composite multiscale entropy (RC MSE) and refined composite multiscale fuzzy entropy (RC MFE) were used to measure the complexity of the local blood flux. The sample entropy was calculated to evaluate the HRV complexity. The change of body position did not affect the time domain or frequency domain of HRV, but did reverse the blood flux laterality of the lower extremities. Furthermore, there was a negative correlation between the complexity of right-side blood flux and sample entropy of HRV when the participant was in the -10 degrees position. These results provide a new perspective of the relationship between skin blood flux signals and cardiac function.


1977 ◽  
Vol 53 (3) ◽  
pp. 13P-13P
Author(s):  
D. A. P. Evans ◽  
H. L. Roberts ◽  
W. R. A. Donohoe ◽  
I. Mohammed ◽  
Bernadette Thompson ◽  
...  

1972 ◽  
Vol 42 (6) ◽  
pp. 769-774 ◽  
Author(s):  
I. M. James ◽  
Lindsay MacDonell ◽  
C. Xanalatos

1. Changes in brain and hind-limb blood flow and metabolism have been studied in six dogs before and after the acute shunting of portal vein blood into the systemic circulation. 2. An initial increase in brain blood flow, oxygen and glucose consumption was found. 3. More prolonged shunting caused a fall in flow and in oxygen and glucose utilization by the brain. 4. Although peripheral blood flow and oxygen consumption were reduced by shunting glucose consumption was increased throughout the period of shunting. 5. The possible mechanisms of these changes is discussed, together with their relevance to the causation of encephalopathy in patients after portacaval shunts.


1964 ◽  
Vol 206 (4) ◽  
pp. 793-795 ◽  
Author(s):  
Norma J. Kolthoff ◽  
I. A. Macchi ◽  
Leland C. Wyman

Blood flow rates of intact rat adrenal glands and 30-day regenerated mesenteric transplants or enucleates were determined before and during stress. Venous flow rates were measured directly, and adrenal venous plasma and glandular corticoids were measured fluorimetrically. Arterial flow was determined by cardiac output fractionation employing Rb86 before and after 4-hr exposure to 4 C. In rats subjected to laparotomy, venous flow rate from regenerated enucleated glands was 42% less than that from intact glands, and the plasma corticoid level was 29% lower, while the glandular level was 33% higher. Arterial inflow of intact adrenals, transplants, and enucleates was approximately the same without stress and increased by similar amounts during cold stress. The ratio of adrenal outflow-to-inflow during stress was lower for regenerated than for intact glands. These results suggest an adrenal vascular abnormality on the venous side of regenerated tissue which prevents release of corticoids into the systemic circulation at a normal rate.


1987 ◽  
Vol 26 (05) ◽  
pp. 192-197 ◽  
Author(s):  
T. Kreisig ◽  
P. Schmiedek ◽  
G. Leinsinger ◽  
K. Einhäupl ◽  
E. Moser

Using the 133Xe-DSPECT technique, quantitative measurements of regional cerebral blood flow (rCBF) were performed before and after provocation with acetazolamide (Diamox) i. v. in 32 patients without evidence of brain disease (normals). In 6 cases, additional studies were carried out to establish the time of maximal rCBF increase which was found to be approximately 15 min p. i. 1 g of Diamox increases the rCBF from 58 ±8 at rest to 73±5 ml/100 g/min. A Diamox dose of 2 g (9 cases) causes no further rCBF increase. After plotting the rCBF before provocation (rCBFR) and the Diamox-induced rCBF increase (reserve capacity, Δ rCBF) the regression line was Δ rCBF = −0,6 x rCBFR +50 (correlation coefficient: r = −0,77). In normals with relatively low rCBF values at rest, Diamox increases the reserve capacity much more than in normals with high rCBF values before provocation. It can be expected that this concept of measuring rCBF at rest and the reserve capacity will increase the sensitivity of distinguishing patients with reversible cerebrovascular disease (even bilateral) from normals.


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