Psychophysiological Adaptation of Patients with Local Radiation Injuries

2018 ◽  
pp. 11-16
Author(s):  
Неля Метляева ◽  
Nelya Metlyaeva ◽  
В. Краснюк ◽  
V. Krasnuk ◽  
Андрей Бушманов ◽  
...  
Keyword(s):  
Interpersonal Relationships ◽  
Work Group ◽  
Physiological Adaptation ◽  
Radiation Injuries ◽  
Psychophysiological Examination ◽  
Production Group ◽  
Local Radiation ◽  
Group 2 ◽  
Adaptation Disorder ◽  
Intellectual Characteristics

Purpose: Assessment of psycho-physiological adaptation of patients with local radiation injuries (LRI), depending on the presence or absence of an established connection with an accident at work in connection with a radiation accident or an incident that has undergone a psychophysiological examination. Material and methods: Clinical and psychophysiological examination of 57 patients with local radiation injuries was performed, 20 of them, whose LRI s were associated with an accident at work (Group 1) and 37 patients, whose LRI connection was not established with production (Group 2). The mean age of the examined subjects was 41.6 ± 3.1 and 52.0 ± 1.6 years. The psychophysiological examination was carried out using the automated program-methodical complex “Expert”, designed to study the personality of a person, the cognitive and intellectual characteristics of a person using the method of the Multilateral Personality Study is an adaptation of MMPI, the method of Cattell’s 16PF, the Raven test, simple and complex sensorimotor reactions and reaction to a moving object. Results: Clinical and psychophysiological assessment of personality and the actual mental state of patients with LRI having an established connection to an accident at work in comparison with patients with LRI with an unrelated connection with production allowed to determine the main types of disturbance of psychophysiological adaptation in a kind of anxiety-hypochondriacal type of adaptation disorder with a tendency to dissocial behavior in patients with LRI who have an established connection with an accident at work. Conclusion: Anxiety-hypochondriacal type of disturbance of psychophysiological adaptation in patients with LRI is caused primarily by concern about the state of physical health, which determined the tension of mental adaptation with a tendency to neglect social norms and rules of behavior, with a tendency to dissocial behavior, psychasthenia, autization, distancing, alienation, affective rigidity, the desire to put the blame on others for the violation of interpersonal relationships, life difficulties and emotions conflicts. The dissocial type of the disturbance of psychophysiological adaptation was revealed mainly in patients with LRI who have established connection with an accident at work.

Value of psychophysiological adaptation of patients with local radiation injuries in their further treatment and rehabilitation

2020 ◽  
pp. 821-821
Author(s):  
O. V. Shcherbatykh
Keyword(s):  
Physiological Adaptation ◽  
Radiation Injuries ◽  
Local Radiation ◽  
And Control

The purpose of the study is to research the psycho-physiological adaptation in two groups: patients with local radiation injuries and control. To do this, tests were conducted MMPI, Kattell’s test, Raven’s test, sensorimotor reactions. At the same time, several changes were revealed in the patients, indicating the need for correction of the neurotic state.

The Outcome of Local Radiation Injuries: 14 Years of Follow-up after the Chernobyl Accident

2001 ◽  
Vol 155 (3) ◽  
pp. 409-416 ◽  
Author(s):  
Petra Gottlöber ◽  
Marianne Steinert ◽  
Melanie Weiss ◽  
Vladimir Bebeshko ◽  
David Belyi ◽  
...  
Keyword(s):  
Chernobyl Accident ◽  
Radiation Injuries ◽  
Local Radiation

scholarly journals Psychological Symptoms in Young Adult Migraineurs

2020 ◽  
Vol 11 (1) ◽  
pp. 42
Author(s):  
Turgay Akalin ◽  
Aysin Sinal
Keyword(s):  
Interpersonal Relationships ◽  
Significant Relationship ◽  
Psychological Symptoms ◽  
Pearson Correlation ◽  
Psychological Symptom ◽  
Age Groups ◽  
Control Group ◽  
Migraine Headaches ◽  
Significant Difference ◽  
Group 2

We aimed to reveal psychological symptoms of young university students (18-25 y/o) with no secondary disease with complaints of migraine headaches. We compared the psychological symptoms with a young control group that did not present headaches and other studies examining migraines in different age groups to determine any similarities. The study consisted of 75 migraine cases; 13 with aura and 62 without aura) and 42 non-headache control subjects. The International Classification of Headache Disorders 3 (ICHD-3) with criteria questions and the Psychological Symptom Research Scale were applied to all participants and SPSS Statistics Program evaluated the data. Findings: 1) In the test of Descriptive Statistics for the Sample of Students, average values of both sexes were taken and found the average values of the migraine groups were higher than control group. 2) The Anova Test found differences in the diagnostic group besides depression (Somatisation p<., others p<.01) with no significant difference in depression (p=0.315). 3)The Pearson Correlation Analysis, found no association between age and psychological symptoms. There’s a significant relationship between psychological symptoms with somatisation (besides paranoid) (p<.05). There’s a significant relationship between depression and other psychological symptoms (p<.05). There’s a significant relationship between anxiety, obsession, interpersonal relationships, psychoticism, paranoia, anger, phobia, additional scale and other psychological symptoms (p<.01). Result: The study demonstrated psychological symptoms in young migraineurs. The average psychological symptoms of both migraine groups were higher than the control group, this showed psychological symptom similarities between young migraineurs and migraine patients of different age groups.

Transplantion of autologous cells of stromal vascular fraction of adipose tissue in severe local radiation injuries of skin caused by x-ray

2017 ◽  
Vol 62 (1) ◽  
pp. 5-11 ◽  
Author(s):  
Бушманов ◽  
Andrey Bushmanov ◽  
Самойлов ◽  
Alyeksandr Samoylov ◽  
Добрынина ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Clinical Manifestations ◽  
Stromal Vascular Fraction ◽  
Control Group ◽  
Tissue Cell ◽  
X Rays ◽  
Radiation Injuries ◽  
X Ray ◽  
Local Radiation ◽  
Radiation Ulcers

Purpose: To investigate the effectiveness of autologous cells of stromal vascular fraction of adipose tissue in severe local radiation skin injuries after the exposure of rats to X-rays. Material and methods: Experiments were performed on Wistar rats, weighing 200–230 g. Rats were exposed locally in iliolumbar region using X-ray machine LNC-268 (RAP 100-10) at a dose of 110 Gy (30 kV tube voltage, current 6.1 mA, thick Al filter 0.1 mm), dose rate: 17.34 Gy/min. Area of the irradiation field was 8.2–8.5 cm2. Transplantation of autologous cells of stromal vascular fraction (SVFC) of adipose tissue was carried out on 21st or 35th days after irradiation. SVFC isolation was performed by means of enzymatic treatment of adipose tissue. SVFC suspension was administered subcutaneously at a dose of 1×106 cells per injection around the radiation ulcers.The severity of radiation damage to the skin and the effects of cellular therapy were evaluated in the dynamics of clinical manifestations, with the help of plane geometry and pathomorphometry. Results: It was found that by the 17–25th day after irradiation radiation ulcers were formedon rat skin. In the control group of animalsulcers persisted throughout the observation period of more than 3 months. The area of ulcers was 1,87 ± 0,35 cm2 and 1.52 ± 0.24 cm2 at 83th and 90th days after irradiation, respectively. In animals of the experimental group, with autologous stromal vascular fraction of adipose tissue, was significant decrease in ulceration the area in comparison to control animals. In 80 % of the rats treated with SVFC on 21st day after exposure, to the 90th day after irradiation complete healing of ulcers occurred with the formation of atrophic scar at the site of radiation injuries. These clinical observations and planimetric were correlated with the results of histomorphometry. Conclusion: Transplantation autologous SVFC of adipose tissue contributes to accelerate the healing of radiation ulcers after local x-ray exposure in the experiment, indicating that the prospects of using adipose tissue cell products for the treatment of severe local radiation injuries.

Investigation of the Influence of the Conditioning Medium Factors Obtained During the Cultivation of Bone Marrow Mesenchymal Stem Cells on the Course of Severe Local Radiation Injuries of Skin in Rats

2018 ◽  
Vol 63 (1) ◽  
pp. 35-43 ◽  
Author(s):  
А. Темнов ◽  
A. Temnov ◽  
Т. Астрелина ◽  
T. Astrelina ◽  
К. Рогов ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Skin Lesion ◽  
Conditioned Medium ◽  
Radiation Injuries ◽  
Lesion Area ◽  
Paracrine Factors ◽  
Local Radiation ◽  
Radiation Ulcers

Purpose: Study of the effect of paracrine factors, produced by MMSC of bone marrow during the cultivation, on the severity of local radiation injuries in the conditions of application in the early periods after irradiation. Material and methods: Experiments were performed on rats of the breed Wistar weighing 280 g. Rats were exposed locally in iliolumbar region of the back using X-ray machine LNC-268 (RAP 100-10) at a dose of 110 Gy (30 kV tube voltage, current 6.1 mA, filter Al 0.1 mm thick), dose rate is 21.4 Gy/min. Area of the irradiation field was 8.2–8.5 cm2. The conditioned medium obtained by culturing MMSC of rats’ bone marrow was administered in dose 1.0 ml (total protein 8 mg/ml) at 1, 3, 6, 8 and 10 days after irradiation. The severity of radiation damage to the skin and the effects of therapy were evaluated in dynamics by clinical manifestations, using planimetry and histological methods. Results: It was shown that in control animals and in rats, with the introduction of the conditioned medium, the values of the skin lesion area in the period up to the 29th day after irradiation practically did not differ, gradually decreasing in control animals from 5.9 ± 0.6 cm2 to 2.2 ± 0.3 cm2 at the 15th and 29th days after irradiation, respectively. Then, in the control group, the lesion area ranged from 1.4 ± 0.6 cm2 on the 50th day to 1.9 ± 0.8 cm2 on the 71st day. In the experimental group of animals, with the introduction of factors of the conditioning medium, a decrease in the area of the lesion and a stable dynamics of healing of radiation ulcers, beginning from the 36th day, there was a gradual decrease in the area of the lesion, which reached 0.2 ± 0.1 cm2 by the 71st day after irradiation. On the 64–71th day after irradiation, the difference between the areas of skin lesion in the experimental and control groups was statistically significant, p <0.05. The histological analysis showed that the use of paracrine factors obtained from MMSC in the process of cultivation significantly reduces the severity of the inflammatory reaction and accelerates the regeneration processes. Conclusion: Thus, the introduction of conditioned medium factors obtained during the cultivation of mesenchymal stem cells of the bone marrow facilitates a more easy flow of the pathological process and the healing of radiation ulcers after local radiation damage to the skin of rats. Apparently, the favorable effect of paracrine factors introduced in the early periods after irradiation, with severe local radiation injuries, is associated with their effect on pathological processes in the inflammatory-destructive stage.

scholarly journals Cutaneous and local radiation injuries

2021 ◽  
Author(s):  
Carol J Iddins ◽  
Andrea Lynn DiCarlo ◽  
Mark D. Ervin ◽  
Eduardo Herrera-Reyes ◽  
Ronald Goans
Keyword(s):  
Radiation Injuries ◽  
Local Radiation

Analysis of the efficiency of the application of cell therapy for local radiation injurie

2021 ◽  
Vol 66 (1) ◽  
pp. 69-78
Author(s):  
V. Brunchukov ◽  
T. Astrelina ◽  
A. Samoylov
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Cell Therapy ◽  
Standard Treatment ◽  
Independent Method ◽  
Radiation Injuries ◽  
Complex Therapy ◽  
Local Radiation ◽  
Methods Of Treatment

Every year the proportion of radiation therapy as an independent method of radical treatment of cancer patients is increasing. Exposure to radiation as a result of medical treatment can lead to the development in patients of local radiation injuries (LRJ) (radiation reactions) on the skin and surrounding tissues. Today, there is no standard treatment for LRJ, known methods are ineffective In this regard, research aimed at finding effective methods of treatment leading to accelerated wound healing, a decrease in inflammation and a decrease in fibrosis is relevant. In recent years, there has been an active study of the effectiveness of the use of cell therapy, including mesenchymal stem cells, their cell products, minimally manipulated cell products, etc., in complex therapy for local radiation injuries. In the presented literature review, the effectiveness of the use of cellular products in local radiation damage to the skin caused by sources of ionizing radiation is considered. Bibliographic searches of works were carried out on the basis of the PubMed portal, published in the period from 2015 to August 2020.

Effects of Exposure to Psychophysical Scaling on Lingual Vibrotactile Magnitude Estimation and Magnitude Production

1986 ◽  
Vol 63 (1) ◽  
pp. 67-74 ◽  
Author(s):  
Donald Fucci ◽  
Daniel Harris ◽  
Elise Mc Math ◽  
Linda Petrosino
Keyword(s):  
Magnitude Estimation ◽  
Prior Exposure ◽  
Magnitude Production ◽  
Production Values ◽  
Psychophysical Scaling ◽  
Significant Difference ◽  
Scaling Methods ◽  
Production Group ◽  
Group 2 ◽  
Group 1

The purpose of the present study was to determine if the results obtained by the scaling methods of magnitude estimation and magnitude production could be influenced by providing subjects with prior exposure to psychophysical scaling in the form of magnitude estimation or magnitude production. Group 1 ( n = 10, Mage = 21.1 yr.) performed lingual vibrotactile-magnitude estimation followed by lingual vibrotactile magnitude production. Group 2 ( n = 10, Mage = 19.7 yr.) performed lingual vibrotactile-magnitude production (using the magnitude-estimation responses provided by Group 1), followed by lingual vibrotactile-magnitude estimation. For the magnitude estimations there was no over-all statistically significant difference between the two groups, but there was for the magnitude-production values. Magnitude-estimation scaling was apparently not influenced by prior exposure to magnitude production, while magnitude-production scaling was influenced by prior exposure to magnitude estimation. The results are discussed in terms of how subjective scaling behavior in psychophysical experimentation may be influenced by the interaction between an absolute internal scaling mechanism and parameters set by the experimenter, such as scaling method and range of stimulus intensity.

Sign in / Sign up

Export Citation Format

Share Document