scholarly journals COVID toes: a unique cutaneous indicator of COVID-19

2021 ◽  
Vol 9 (39) ◽  
pp. 15-21
Author(s):  
Travis Dowdle ◽  
Todd Brown ◽  
Joshua Peterson ◽  
Kiana Banafshay ◽  
Jeannie Nguyen ◽  
...  
Keyword(s):  
Young Adults ◽  
Differential Diagnosis ◽  
General Population ◽  
Literature Review ◽  
Public Interest ◽  
Healthcare Workers ◽  
Inflammatory Disorder ◽  
Trends Analysis ◽  
Additional Testing ◽  
Children And Young Adults

Background: This brief review considers major aspects of COVID toes as currently understood. Topics discussed include etiology, pathophysiology, differential diagnosis, treatment, and management. Media characterization, potentially leading to intense public interest in COVID toes during the summer of 2020, is also discussed. Methods: The literature review was conducted by selecting articles from PUBMED, SCOPUS, EMBASE, and Google Scholar based on the relevance to our topic. To determine the relative search interest of the general population, a Google Trends analysis was queried on 11/17/20 for the retrospective duration of 11/17/2019–11/17/2020. Results: The majority of patients who have presented with COVID toes are children and young adults. COVID toes generally present as acro-ischemic lesions, which are microthrombotic events in the extremities, leading to symptoms such as pseudo-chilblains or pernio-like lesions. Chilblains are histologically classified as an inflammatory disorder with a prominent perivascular lymphocytic infiltrate seen on microscopy. The regions are described as appearing erythematous to purple purpuric macules, papules, and/or vesicles. In many cases, COVID toes symptoms are self-limiting. Conclusion: The development of COVID toes represents an additional manifestation of COVID-19 that should lead to additional testing. Knowledge of these symptoms can give healthcare workers and the general public another tool for recognizing COVID-19. Keywords: COVID toes, COVID-19, coronavirus, chilblains, pernio

scholarly journals Visual performance and ocular abnormalities in deaf children and young adults: a literature review

2013 ◽  
Vol 92 (4) ◽  
pp. 305-310 ◽  
Author(s):  
Richard Hollingsworth ◽  
Amanda K. Ludlow ◽  
Arnold Wilkins ◽  
Richard Calver ◽  
Peter M. Allen
Keyword(s):  
Young Adults ◽  
Literature Review ◽  
Visual Performance ◽  
Deaf Children ◽  
Ocular Abnormalities ◽  
Children And Young Adults

scholarly journals Tufted angioma in ear auricle: importance of the differential diagnosis

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 113-115 ◽  
Author(s):  
Carla Andréa Avelar Pires ◽  
Brena Andrade de Sousa ◽  
Gabriela Athayde Amin ◽  
Maraya de Jesus Semblano Bittencourt ◽  
Mario Fernando Ribeiro de Miranda ◽  
...  
Keyword(s):  
Young Adults ◽  
Differential Diagnosis ◽  
Clinical Features ◽  
Male Patient ◽  
Lepromatous Leprosy ◽  
Vascular Proliferation ◽  
Tufted Angioma ◽  
Ear Auricle ◽  
Histological Characteristics ◽  
Children And Young Adults

Tufted angioma is an acquired vascular proliferation with specific histological characteristics. The most common clinical features are erythematous macules. It occurs predominantly in children and young adults, especially in the chest and neck. We report the case of a male patient, 12 years old, with an increased right ear auricle associated with erythematous macules and increased local temperature, referred with a diagnosis of lepromatous leprosy; however, this diagnosis was questioned. Histopathology was consistent with tufted angioma.

Abstract 18284: Incidence of Epilepsy is Elevated in Children and Young Adults With Congenital Heart Defects Compared With the General Population: A Nationwide Cohort Study

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Morten Olsen ◽  
Bradley S Marino ◽  
Michelle Leisner ◽  
Jessica G Woo ◽  
Nicolas L Madsen
Keyword(s):  
Young Adults ◽  
Preterm Birth ◽  
General Population ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Birth Registry ◽  
Registration System ◽  
Children And Young Adults

Perioperative seizures related to surgery for congenital heart defects (CHD) are well described; however, few data exist on the long-term risk of epilepsy in patients with CHD. We aimed to estimate the incidence of epilepsy in children and young adults with CHD compared with the general population. Methods: Utilizing data from the Danish National Registry of Patients (DNRP) we identified all patients diagnosed with CHD before the age of 15 years between 1980 and 2010 who were born during the same period. The DNRP is a nationwide hospital discharge registry covering all Danish hospitals. Previously validated methodology using the DNRP was applied to measure the outcome, epilepsy, as well as presence of extra cardiac defects (ECD) and/or syndromes. We used the Danish Medical Birth Registry to identify preterm birth (gestational age<37 weeks). For each CHD subject, we identified 10 controls from the general population using the Danish Civil Registration System, matched by sex and birth year. A unique personal identifier assigned at birth and used in all Danish public registries enabled virtually complete follow up for migration, death, or epilepsy until January 1, 2013. We computed cumulative incidences and hazard ratios (HR) (split at 5 years of age to obtain proportional hazards) of time from CHD diagnosis (index date for controls) to epilepsy. Results: We identified 14,665 CHD subjects with a median age at diagnosis of 2 (IQR 19) months. By 15 years of age, the cumulative incidence of epilepsy was 4% among CHD subjects. The HR of epilepsy among CHD subjects compared with the control cohort was 3.7 (95% CI: 3.2-4.3) below 5 years of age, and 2.4 (95% CI: 2.1-2.7) from 5 to 33 years of age. In the older age group, HR for patients with severe CHD was 2.8 (95% CI: 2.3-3.5), and for mild and moderate CHD was 2.2 (95% CI: 1.8-2.6). After exclusion of all subjects with ECDs and/or syndromes and preterm birth, corresponding HRs were 2.2 (95% CI: 1.6-3.0) and 1.7 (95% CI: 1.3-2.2), respectively. Conclusion: The epilepsy risk was markedly increased in CHD subjects compared with the age and gender matched controls. These findings add evidence to support the importance of developing neuro-protective measures and potentially long-term epilepsy surveillance strategies in the CHD population.

scholarly journals Multiple Large Pyogenic Granulomas Overlying a Burn: Case Report and Literature Review

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Krieger Y ◽  
Weiss E ◽  
Horev A ◽  
Melamed R ◽  
Shoham Y ◽  
...  
Keyword(s):  
Young Adults ◽  
Case Report ◽  
Literature Review ◽  
Burn Injury ◽  
Pyogenic Granuloma ◽  
Vascular Lesion ◽  
Penetrating Injury ◽  
Children And Young Adults

Pyogenic granuloma is a vascular lesion of the skin commonly found in children and young adults. It is known to erupt following skin laceration or penetrating injury, but is only rarely reported in children after a burn injury.

Angiomatoid Fibrous Histiocytoma: A Review With Recent Genetic Findings

2008 ◽  
Vol 132 (2) ◽  
pp. 273-277 ◽  
Author(s):  
Khin Thway
Keyword(s):  
Young Adults ◽  
Differential Diagnosis ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Molecular Genetic ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Lymphoplasmacytic Infiltrate ◽  
Children And Young Adults

Abstract Angiomatoid fibrous histiocytoma is a neoplasm of intermediate biologic potential most often arising in the extremities of children and young adults. Its rarity may lead to misdiagnosis as either a reactive lesion or a benign or higher-grade tumor. Originally described as a type of malignant fibrous histiocytoma, its differentiation remains enigmatic, with precise histogenesis still only hypothesized. Its morphology is distinct, as a circumscribed lesion with sheets of bland spindle to ovoid cells, peripheral lymphoplasmacytic infiltrate, and blood-filled cystic cavities, and half of the cases show strong desmin expression. Cytogenetically, 2 specific translocations, t(12:16)(q13:p11) and more recently t(12:22)(q13:q12), have been characterized. The literature on angiomatoid fibrous histiocytoma is reviewed, particularly with regard to recent molecular genetic developments and differentiation, and its morphology, immunohistochemistry, and differential diagnosis are summarized.

scholarly journals Mycoplasma pneumoniae-Induced-Stevens Johnson Syndrome: Rare Occurrence in an Adult Patient

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Samad Rasul ◽  
Faria Farhat ◽  
Yared Endailalu ◽  
Fatima Tabassum Khan ◽  
Vishal Poddar
Keyword(s):  
Young Adults ◽  
Differential Diagnosis ◽  
Adult Patient ◽  
Mycoplasma Pneumoniae ◽  
Stevens Johnson Syndrome ◽  
Rare Occurrence ◽  
Drug Induced ◽  
Johnson Syndrome ◽  
Cutaneous Rash ◽  
Children And Young Adults

Stevens-Johnson syndrome (SJS) is an uncommon occurrence inMycoplasma pneumoniae(M. pneumoniae) infection (1–5%) and has been mainly reported in children and young adults. We present a case of SJS in a 32-year-old male induced byM. pneumoniaeinfection. This patient presented with fever, cough, and massive occupation of mucus membranes with swelling, erythema, and necrosis accompanied by a generalized cutaneous rash. He clinically responded after treatment with antibiotics and IVIG. SJS is usually a drug-induced condition; however,M. pneumoniaeis the commonest infectious cause and should be considered in the differential diagnosis.

scholarly journals Selecting Optimal Access for Facial Cyst Removal: A Case Report and Literature Review

2005 ◽  
Vol 13 (1) ◽  
pp. 31-32 ◽  
Author(s):  
Marion Grob ◽  
Mark George Soldin
Keyword(s):  
Young Adults ◽  
Case Report ◽  
Literature Review ◽  
Present Case Report ◽  
Cyst Excision ◽  
Epidermoid Cysts ◽  
Children And Young Adults

Benign subcutaneous facial cysts are common in children and young adults. They are largely of cosmetic concern. Removal of sebaceous and epidermoid cysts in this population can leave unsightly scars, occasionally worse in appearance than the original pathology. In the present case report, the technique of cyst excision via an intaoral route is outlined. The literature review emphasizes the importance of placing facial incisions in inconspicuous areas.

scholarly journals Child Neurology: Differential diagnosis of a low CSF glucose in children and young adults

Neurology ◽  
2013 ◽  
Vol 81 (24) ◽  
pp. e178-e181 ◽  
Author(s):  
W. G. Leen ◽  
C. J. de Wit ◽  
R. A. Wevers ◽  
B. G. van Engelen ◽  
E.-J. Kamsteeg ◽  
...  
Keyword(s):  
Young Adults ◽  
Differential Diagnosis ◽  
Child Neurology ◽  
Children And Young Adults

scholarly journals Seroprevalence of antibody to varicella zoster virus in England and Wales in children and young adults

2004 ◽  
Vol 132 (6) ◽  
pp. 1129-1134 ◽  
Author(s):  
A. J. VYSE ◽  
N. J. GAY ◽  
L. M. HESKETH ◽  
P. MORGAN-CAPNER ◽  
E. MILLER
Keyword(s):  
Young Adults ◽  
General Population ◽  
Varicella Zoster Virus ◽  
Large Scale ◽  
Age Group ◽  
England And Wales ◽  
Varicella Zoster ◽  
Mixture Modelling ◽  
Children And Young Adults ◽  
Prior Infection

This is the first large-scale study to investigate the seroprevalence of varicella zoster (VZV) in the general population of England and Wales. The study focused on those aged 1–20 years, that age group in whom most infections occur. Prevalence rose rapidly with age, with 53% of children showing evidence of prior infection by the age of 5 years and most young adults having experienced infection. In addition to using a fixed cut-off recommended by the manufacturer, a mixture modelling technique was also used to define the proportion of the population seropositive in each age group. This was shown to be a more accurate approach to categorizing data from an epidemiological perspective.

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