Angiomatoid Fibrous Histiocytoma: A Review With Recent Genetic Findings

2008 ◽  
Vol 132 (2) ◽  
pp. 273-277 ◽  
Author(s):  
Khin Thway
Keyword(s):  
Young Adults ◽  
Differential Diagnosis ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Molecular Genetic ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Lymphoplasmacytic Infiltrate ◽  
Children And Young Adults

Abstract Angiomatoid fibrous histiocytoma is a neoplasm of intermediate biologic potential most often arising in the extremities of children and young adults. Its rarity may lead to misdiagnosis as either a reactive lesion or a benign or higher-grade tumor. Originally described as a type of malignant fibrous histiocytoma, its differentiation remains enigmatic, with precise histogenesis still only hypothesized. Its morphology is distinct, as a circumscribed lesion with sheets of bland spindle to ovoid cells, peripheral lymphoplasmacytic infiltrate, and blood-filled cystic cavities, and half of the cases show strong desmin expression. Cytogenetically, 2 specific translocations, t(12:16)(q13:p11) and more recently t(12:22)(q13:q12), have been characterized. The literature on angiomatoid fibrous histiocytoma is reviewed, particularly with regard to recent molecular genetic developments and differentiation, and its morphology, immunohistochemistry, and differential diagnosis are summarized.

scholarly journals Angiomatoid Fibrous Histiocytoma in the Forearm: A Case Report

2016 ◽  
Vol 6 (1) ◽  
pp. 36
Author(s):  
Hatim Mohammed A Alshareef ◽  
Ahmed Hassan A Alhasan ◽  
Mohammed G. Felemban ◽  
Ashwaq Mohammed J Almalki ◽  
Amer Mohammed A Alshareef
Keyword(s):  
Young Adults ◽  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Fibrous Histiocytoma ◽  
Full Range ◽  
Common Site ◽  
Tissue Mass ◽  
Skin Changes ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Children And Young Adults

Background: Angiomatoid fibrous histiocytoma [AFH] is a rare soft tissue tumor most commonly occurring in children, adolescents, and young adults. It is considered to be a tumor of intermediate malignancy because of its less aggressive course. The extremities are the most common site of involvement, followed by the trunk and head and neck.Case presentation: A 28-Year-old male presented with a right forearm mass that has been present for 2 years. There was no associated fever, no trauma, no night pain and no constitutional symptoms. On examination he had a forearm mass dorsally measuring 2x3 cm, firm, rounded, mobile with no skin changes and full range motion joint above and joint below. Lab and imaging studies done which showed soft tissue mass, multilobulated complex heterogeneous with increased vascularity. Patient underwent biopsy and surgical excision.Conclusion: Angiomatoid fibrous histiocytoma is a neoplasm of intermediate biologic potential. Most often, the extremities are the most common site of involvement, followed by the trunk and head and neck of children and young adults. Its rarity may lead to misdiagnosis as either a reactive lesion or a benign or higher-grade tumor. This tumor has a relatively rare metastasis and its overall clinical outcome is excellent. It is clinically important to accurately diagnose this tumor so that wide local excision may be performed and patients may be appropriately monitored and followed up.

scholarly journals Tufted angioma in ear auricle: importance of the differential diagnosis

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 113-115 ◽  
Author(s):  
Carla Andréa Avelar Pires ◽  
Brena Andrade de Sousa ◽  
Gabriela Athayde Amin ◽  
Maraya de Jesus Semblano Bittencourt ◽  
Mario Fernando Ribeiro de Miranda ◽  
...  
Keyword(s):  
Young Adults ◽  
Differential Diagnosis ◽  
Clinical Features ◽  
Male Patient ◽  
Lepromatous Leprosy ◽  
Vascular Proliferation ◽  
Tufted Angioma ◽  
Ear Auricle ◽  
Histological Characteristics ◽  
Children And Young Adults

Tufted angioma is an acquired vascular proliferation with specific histological characteristics. The most common clinical features are erythematous macules. It occurs predominantly in children and young adults, especially in the chest and neck. We report the case of a male patient, 12 years old, with an increased right ear auricle associated with erythematous macules and increased local temperature, referred with a diagnosis of lepromatous leprosy; however, this diagnosis was questioned. Histopathology was consistent with tufted angioma.

scholarly journals COVID toes: a unique cutaneous indicator of COVID-19

2021 ◽  
Vol 9 (39) ◽  
pp. 15-21
Author(s):  
Travis Dowdle ◽  
Todd Brown ◽  
Joshua Peterson ◽  
Kiana Banafshay ◽  
Jeannie Nguyen ◽  
...  
Keyword(s):  
Young Adults ◽  
Differential Diagnosis ◽  
General Population ◽  
Literature Review ◽  
Public Interest ◽  
Healthcare Workers ◽  
Inflammatory Disorder ◽  
Trends Analysis ◽  
Additional Testing ◽  
Children And Young Adults

Background: This brief review considers major aspects of COVID toes as currently understood. Topics discussed include etiology, pathophysiology, differential diagnosis, treatment, and management. Media characterization, potentially leading to intense public interest in COVID toes during the summer of 2020, is also discussed. Methods: The literature review was conducted by selecting articles from PUBMED, SCOPUS, EMBASE, and Google Scholar based on the relevance to our topic. To determine the relative search interest of the general population, a Google Trends analysis was queried on 11/17/20 for the retrospective duration of 11/17/2019–11/17/2020. Results: The majority of patients who have presented with COVID toes are children and young adults. COVID toes generally present as acro-ischemic lesions, which are microthrombotic events in the extremities, leading to symptoms such as pseudo-chilblains or pernio-like lesions. Chilblains are histologically classified as an inflammatory disorder with a prominent perivascular lymphocytic infiltrate seen on microscopy. The regions are described as appearing erythematous to purple purpuric macules, papules, and/or vesicles. In many cases, COVID toes symptoms are self-limiting. Conclusion: The development of COVID toes represents an additional manifestation of COVID-19 that should lead to additional testing. Knowledge of these symptoms can give healthcare workers and the general public another tool for recognizing COVID-19. Keywords: COVID toes, COVID-19, coronavirus, chilblains, pernio

Intracranial angiomatoid fibrous histiocytoma presenting as recurrent multifocal intraparenchymal hemorrhage

2010 ◽  
Vol 112 (5) ◽  
pp. 978-982 ◽  
Author(s):  
Pawel G. Ochalski ◽  
James T. Edinger ◽  
Michael B. Horowitz ◽  
William R. Stetler ◽  
Geoffrey H. Murdoch ◽  
...  
Keyword(s):  
Cavernous Malformation ◽  
Fibrous Histiocytoma ◽  
Biological Behavior ◽  
Intraparenchymal Hemorrhage ◽  
Soft Tissue Neoplasm ◽  
Recurrent Hemorrhage ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Molecular Studies ◽  
Resection Specimen ◽  
Children And Young Adults

Angiomatoid fibrous histiocytoma (AFH) is a rare soft-tissue neoplasm that most commonly appears in the limbs, typically affecting children and young adults. The tumor has a propensity for local recurrence and recurrent hemorrhage but rarely for remote metastasis. To date, only 2 reports have documented an intracranial occurrence of the tumor (1 of which was believed to be metastatic disease). This is the second report of primary intracranial AFH. Additionally, hemorrhage from an intracranial AFH lesion has yet to be reported, and little is known about the radiographic characteristics and biological behavior of these lesions. In this report, the authors describe the case of a patient with recurrent hemorrhage due to primary multifocal intracranial AFH. Initially misdiagnosed as a cavernous malformation and then an unusual meningioma, the tumor was finally correctly identified when there was a large enough intact resection specimen to reveal the characteristic histological pattern. The diagnosis was confirmed using immunohistochemical and molecular studies.

Reticular angiomatoid “malignant” fibrous histiocytoma—a case report with cytogenetics and molecular genetic analyses

2011 ◽  
Vol 42 (9) ◽  
pp. 1359-1363 ◽  
Author(s):  
Rafael D. Moura ◽  
Xiaoke Wang ◽  
Melissa L. Lonzo ◽  
Michele R. Erickson-Johnson ◽  
Joaquín J. García ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Molecular Genetic ◽  
Genetic Analyses

scholarly journals The Vascular Swirls- Angiomatoid Fibrous Histiocytoma

2021 ◽  
Vol 1 (3) ◽  
pp. 15-23
Author(s):  
Anubha Bajaj
Keyword(s):  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Distant Metastasis ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Neoplasm ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Pleomorphic Sarcoma

Angiomatoid fibrous histiocytoma (AFH) is an exceptional, soft tissue neoplasm of indeterminate lineage and intermediate malignancy associated with minimal localized tumour reoccurrence and infrequent distant metastasis. Preliminarily contemplated to be a variant or derivative of malignant fibrous histiocytoma or undifferentiated pleomorphic sarcoma or an unusual fibrohistiocytic sarcoma, angiomatoid fibrous histiocytoma predominantly incriminates young po pulation and superficial sites although several extra-somatic sites can be implicated.

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