A Single Large Dose of Tranexamic Acid before Vaginal Delivery : Is It Beneficial ?

2017 ◽  
Vol 69 (6) ◽  
pp. 2601-2606
Author(s):  
Ahmed Abd Elhamid ◽  
Ashraf Hamdy ◽  
Sileem Ahmed Sileem
Keyword(s):  
Tranexamic Acid ◽  
Vaginal Delivery ◽  
Large Dose ◽  
Single Large Dose

Dothiepin for depression: single nightly dosage

1977 ◽  
Vol 15 (23) ◽  
pp. 92-92
Keyword(s):  
Single Dose ◽  
Depressed Patient ◽  
Large Dose ◽  
Half Life ◽  
Dosage Regimen ◽  
The Body ◽  
Dry Mouth ◽  
Blurred Vision ◽  
Depressed Patients ◽  
Single Large Dose

Depressed patients tend to be forgetful, and for them a simple dosage regimen is particularly appropriate. The use of a single daily dosage depends on the drug having a relatively long (over 36 hours) half-life in the body and being tolerated in a single large dose. Many tricyclic anti-depressives fulfil these requirements provided that the single dose is given before the patient goes to bed. Unwanted effects such as dry mouth and blurred vision, which are troublesome during the day, are not a problem during sleep. The sedative actions of many of these drugs can help the insomniac depressed patient who might otherwise need a separate hypnotic.

scholarly journals Tranexamic Acid for the Prevention of Blood Loss after Vaginal Delivery

2018 ◽  
Vol 379 (8) ◽  
pp. 731-742 ◽  
Author(s):  
Loïc Sentilhes ◽  
Norbert Winer ◽  
Elie Azria ◽  
Marie-Victoire Sénat ◽  
Camille Le Ray ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Vaginal Delivery

Nephrotoxicity and Oxidative Stress of Single Large Dose or Two Divided Doses of Gentamicin in Rats

2011 ◽  
Vol 14 (11) ◽  
pp. 627-633 ◽  
Author(s):  
Mahmoud Kandeel ◽  
Iman Abdelaziz ◽  
Nagwan Elhabashy ◽  
Hanaa Hegazy ◽  
Yasmin Tolba
Keyword(s):  
Oxidative Stress ◽  
Large Dose ◽  
And Oxidative Stress ◽  
Single Large Dose

Prophylactic use of tranexamic acid after vaginal delivery reduces the risk of primary postpartum hemorrhage

2019 ◽  
Vol 33 (19) ◽  
pp. 3368-3376 ◽  
Author(s):  
Gabriele Saccone ◽  
Luigi Della Corte ◽  
Pietro D’Alessandro ◽  
Bruno Ardino ◽  
Luigi Carbone ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Vaginal Delivery ◽  
Postpartum Hemorrhage ◽  
Prophylactic Use

scholarly journals The Efficacy of Intravenous Tranexamic Acid in Reduction of Blood Loss in Women at High Risk of Postpartum Hemorrhage

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
K M Diab ◽  
R M Mohamed ◽  
A G Abdelhay
Keyword(s):  
Blood Loss ◽  
Cesarean Section ◽  
Tranexamic Acid ◽  
Maternal Mortality ◽  
Vaginal Delivery ◽  
Control Group ◽  
Study Group ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Abstract Background Postpartum hemorrhage (PPH) is the leading cause of maternal mortality. All women who carry a pregnancy beyond 20 weeks’ gestation are at risk for PPH and its sequelae. Although maternal mortality rates have declined greatly in the developed world, PPH remains a leading cause of maternal mortality elsewhere. Aim of the Work To assess the efficacy and safety intravenous tranexamic acid in reduction of amount of blood loss in high risk women who deliver by cesarean section or vaginal delivery in postpartum period. Patients and Methods This prospective double blind randomized controlled clinical trial study was conducted on 200 patients planned for LSCS or vaginal delivery at Gestational Age ≥ 34 Weeks at Ain Shams University Maternity Hospital. Recruitment of data begun once the protocol was approved by research and ethical committee of the department of obstetrics and gynecology. Results No significant difference between Study and Control groups as regards age (p = 0.508), no significant difference between Study and Control groups as regards Gestational age (p = 0.447),total blood loss (p < 0.001) was significantly lower in study group than control group, Vaginal pads in the 1st 24 hours post-partum was significantly less soaked in study group than control group (p < 0.001). no significant difference between Study and Control groups as regards Preoperative Hemoglobin, Postoperative Hemoglobin was significantly higher in study group than control group (p < 0.001), Reduction in Hemoglobin was significantly less in study group than control group (p < 0.001), no significant difference between Study and Control groups as regards Preoperative Hematocrite, Postoperative Hematocrit was significantly higher in study group than control group (p < 0.001), Reduction in Hematocrite was significantly less in study group than control group (p < 0.001).Need to iron replacement or blood transfusion was significantly less frequent in study group than control group (p = 0.24). Conclusion The use of tranexamic acid prior to cesarean section or vaginal delivery is effective as a prophylaxis against post-partum hemorrhage as shown by the results of this study. It can significantly reduce blood loss during and after cesarean section or vaginal delivery.

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